Zobrazeno 1 - 8
of 8
pro vyhledávání: '"pharmacology [Protein Kinase Inhibitors]"'
Autor:
von Spreckelsen, Niklas, Waldt, Natalie, Poetschke, Rebecca, Kesseler, Christoph, Dohmen, Hildegard, Jiao, Hui-Ke, Nemeth, Attila, Schob, Stefan, Scherlach, Cordula, Sandalcioglu, Ibrahim Erol, Deckert, Martina, Angenstein, Frank, Krischek, Boris, Stavrinou, Pantelis, Timmer, Marco, Remke, Marc, Kirches, Elmar, Goldbrunner, Roland, Chiocca, E. Antonio, Huettelmaier, Stefan, Acker, Till, Mawrin, Christian
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Acta Neuropathologica Communications 8(1), 41 (2020). doi:10.1186/s40478-020-00912-x
Acta Neuropathologica Communications
Acta Neuropathologica Communications 8(1), 41 (2020). doi:10.1186/s40478-020-00912-x
Acta Neuropathologica Communications
Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical observations. Alterations of cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::306ca425261f423e431772a1a39f2e78
http://link.springer.com/article/10.1186/s40478-020-00912-x
http://link.springer.com/article/10.1186/s40478-020-00912-x
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease
Autor:
Barbara Bettegazzi, Lisa Michelle Restelli, Fabio Grohovaz, Serena Bellani, Alessio Colombo, Daniele Zacchetti, Takashi Saito, Laura Sebastian Monasor, Stephan Frank, Takaomi C. Saido, Sabina Tahirovic, Nikolaus Deigendesch, Sven Lammich, Franca Codazzi
Publikováno v:
Cell death & disease 12(8), 769 (2021). doi:10.1038/s41419-021-04062-3
Cell Death and Disease, Vol 12, Iss 8, Pp 1-14 (2021)
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 8, Pp 1-14 (2021)
Cell Death & Disease
Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder. Increased Aβ production plays a fundamental role in the pathogenesis of the disease and BACE1, the protease that triggers the amyloidogenic processing of APP, is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abd20f498d316c22305ccdddd4e5661
https://doi.org/10.1038/s41419-021-04062-3
https://doi.org/10.1038/s41419-021-04062-3
Autor:
Ying, Fan, Andrew J M, Howden, Adil R, Sarhan, Pawel, Lis, Genta, Ito, Terina N, Martinez, Kathrin, Brockmann, Thomas, Gasser, Dario R, Alessi, Esther M, Sammler
Publikováno v:
Biochemical Journal
Biochemical journal 475(1), 23-44 (2017). doi:10.1042/BCJ20170803
Biochemical journal 475(1), 23-44 (2017). doi:10.1042/BCJ20170803
The addition of phosphate groups to substrates allows protein kinases to regulate a myriad of biological processes, and contextual analysis of protein-bound phosphate is important for understanding how kinases contribute to physiology and disease. Le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::65f956fa3c03c86699d3e431da15e234
http://europepmc.org/articles/PMC5748842
http://europepmc.org/articles/PMC5748842
Autor:
Tatenhorst, Lars, Eckermann, Katrin, Outeiro, Tiago F, Zweckstetter, Markus, Lingor, Paul, Dambeck, Vivian, Fonseca-Ornelas, Luis, Walle, Hagen, Lopes da Fonseca, Tomás, Koch, Jan C, Becker, Stefan, Tönges, Lars, Bähr, Mathias
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications 4(1), 39 (2016). doi:10.1186/s40478-016-0310-y
Acta Neuropathologica Communications 4(1), 39 (2016). doi:10.1186/s40478-016-0310-y
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, yet disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) was recently described as a novel neuroprotective target in PD. Since alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e25ac157886f125890f1f46489256178
https://pubmed.ncbi.nlm.nih.gov/27101974
https://pubmed.ncbi.nlm.nih.gov/27101974
Autor:
Janaky Coomaraswamy, Frank Gillardon, Marta Garcia-Miralles, Mathias Jucker, Saskia Biskup, Dagmar Galter, Karina Häbig, Martina Maisel, Natalja Funk, Martin C. Herzig, Thomas Gasser
Publikováno v:
PLoS ONE
PLOS ONE 10(4), e0118947 (2015). doi:10.1371/journal.pone.0118947
PLoS ONE, Vol 10, Iss 4, p e0118947 (2015)
PLOS ONE 10(4), e0118947 (2015). doi:10.1371/journal.pone.0118947
PLoS ONE, Vol 10, Iss 4, p e0118947 (2015)
Mutations within the LRRK2 gene have been identified in Parkinson's disease (PD) patients and have been implicated in the dysfunction of several cellular pathways. Here, we explore how pathogenic mutations and the inhibition of LRRK2 kinase activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7e6cdd8399aefb612e7e411bdcf9e4
http://europepmc.org/articles/PMC4382199
http://europepmc.org/articles/PMC4382199
Autor:
Paul T. Spellman, Brian Cooper, Joe W. Gray, Claire J. Tomlin, Chris J. Oates, Nora Bayani, Wen-Lin Kuo, Wallace Thompson, Nicholas J. Wang, Safiyyah Ziyad, Lakshmi Jakkula, Yiling Lu, Jenny L. Hung, Gordon B. Mills, Heidi S. Feiler, Obi L. Griffith, Sach Mukherjee, Amanda Esch, Eric A. Collisson, James E. Korkola, Sleiman Itani, Laura M. Heiser, Jessica Billig
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133219 (2015)
PLOS ONE 10(7), e0133219 (2015). doi:10.1371/journal.pone.0133219
PLOS ONE 10(7), e0133219 (2015). doi:10.1371/journal.pone.0133219
We report here on experimental and theoretical efforts to determine how best to combine drugs that inhibit HER2 and AKT in HER2(+) breast cancers. We accomplished this by measuring cellular and molecular responses to lapatinib and the AKT inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4babd21b582e7e149a9c7947567895
http://europepmc.org/articles/PMC4504492?pdf=render
http://europepmc.org/articles/PMC4504492?pdf=render
Autor:
C Rotermund, Philipp J. Kahle, A Ciociaro, B I Pérez-Revuelta, M M Hettich, Donato A. Di Monte, S Krauss
Publikováno v:
Cell death & disease 5(5), e1209-e1209 (2014). doi:10.1038/cddis.2014.175
Cell Death & Disease
Cell Death & Disease
Phospho-Ser129 α-synuclein is the modified form of α-synuclein that occurs most frequently within Parkinson's disease pathological inclusions. Here we demonstrate that the antidiabetic drug metformin significantly reduces levels of phospho-Ser129
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736688cea10e29d69ece6608f1cc9e70
Autor:
Diane K. O'Dowd, Huiping Zhang, Ping Ren, Huaiyu Gu, Yu-Qiang Liu, Fang Qiu, Qun-Yong Zhou, Wang-Ping Hu
Publikováno v:
Ren, Ping; Zhang, Huiping; Qiu, Fang; Liu, Yu-Qiang; Gu, Huaiyu; O'Dowd, Diane K; et al.(2011). Prokineticin 2 regulates the electrical activity of rat suprachiasmatic nuclei neurons.. PloS one, 6(6), e20263-e202e20263. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0j53r5gx
PLoS ONE
PLoS ONE, Vol 6, Iss 6, p e20263 (2011)
PLoS ONE
PLoS ONE, Vol 6, Iss 6, p e20263 (2011)
Neuropeptide signaling plays roles in coordinating cellular activities and maintaining robust oscillations within the mammalian suprachiasmatic nucleus (SCN). Prokineticin2 (PK2) is a signaling molecule from the SCN and involves in the generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba75ed9a7b66ce91f2a67e15489cdbf
https://doi.org/10.1371/journal.pone.0020263
https://doi.org/10.1371/journal.pone.0020263