Zobrazeno 1 - 8
of 8
pro vyhledávání: '"pharmacology [Protease Inhibitors]"'
Autor:
André Rex, Vincent Prinz, Hans M.G. Princen, Paul Fischer, Matthias Endres, Frieder Schlunk, Dieter Lütjohann, Ulrich Laufs, Marco Foddis
Publikováno v:
Behavioural brain research 396, 112875-(2021). doi:10.1016/j.bbr.2020.112875
Behavioral Brain Research, 396
Behavioral Brain Research, 396
Monoclonal anti-proprotein convertase subtilisin/kexin type 9 (PSCK9) neutralizing antibodies effectively lower plasma cholesterol levels and decrease cardiovascular events but also raised some concern that cognitive function could worsen as a side e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57f54470c79c01128abda419148f08a
Publikováno v:
Trends in neurosciences 39(3), 158-169 (2016). doi:10.1016/j.tins.2016.01.003
The protease β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is required for the production of the amyloid-β (Aβ) peptide, which is central to the pathogenesis of Alzheimer's disease (AD). Chronic inhibition of this protease may t
Autor:
Peter J. Dempsey, Alessio Colombo, Huanhuan Wang, Howard C. Crawford, Richard M. Page, Stefan F. Lichtenthaler, Peer-Hendrik Kuhn, Elisabeth Kremmer
Publikováno v:
Neurobiology of Disease, Vol 49, Iss, Pp 137-147 (2013)
Neurobiology of disease 49, 137-147 (2013). doi:10.1016/j.nbd.2012.08.011
Neurobiology of disease 49, 137-147 (2013). doi:10.1016/j.nbd.2012.08.011
Proteolytic cleavage of the amyloid precursor protein (APP) by the two proteases α- and β-secretases controls the generation of the amyloid β peptide (Aβ), a key player in Alzheimer's disease pathogenesis. The α-secretase ADAM10 and the β-secre
Autor:
Karen Beltz, Carine Kolly, Ludovic Perrot, Laurent Morawiec, Laura H. Jacobson, Juliane Schelle, Diethilde Theil, Barbara Bertschi, Robert Kreutzer, Mathias Jucker, Kamal Kumar Balavenkatraman, Derya R. Shimshek, Irena Brzak, Ulf Neumann, Karine Bigot, Natasa Zamurovic, Annabelle Heier, Rainer Machauer
Publikováno v:
Scientific reports 6(1), 21917 (2016). doi:10.1038/srep21917
Scientific Reports
Scientific Reports
Melanocytes of the hair follicle produce melanin and are essential in determining the differences in hair color. Pigment cell-specific MELanocyte Protein (PMEL17) plays a crucial role in melanogenesis. One of the critical steps is the amyloid-like fu
Autor:
Isil Keskin, Elin Forsgren, Jonathan D. Gilthorpe, Anna Birve, Dale J. Lange, Peter M. Andersen, Stefan L. Marklund, Matthis Synofzik, Markus Weber
Publikováno v:
PLOS ONE 11(2), e0150133 (2016). doi:10.1371/journal.pone.0150133
PLoS ONE, Vol 11, Iss 2, p e0150133 (2016)
PLoS ONE
PLoS ONE, Vol 11, Iss 2, p e0150133 (2016)
PLoS ONE
Mutations in superoxide dismutase-1 (SOD1) are a common known cause of amyotrophic lateral sclerosis (ALS). The neurotoxicity of mutant SOD1s is most likely caused by misfolded molecular species, but disease pathogenesis is still not understood. Prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04c3ab95ca3fc0c1f8e436bc49b5f91
https://pub.dzne.de/record/138409
https://pub.dzne.de/record/138409
Autor:
Sabina Tahirovic, Annika Wulf-Goldenberg, Christian Haass, Cyril Cheret, Paul Saftig, Florence R. Fricker, Alistair N. Garratt, Carmen Birchmeier, Hagen Wende, Michael Willem, Klaus-Armin Nave, David L.H. Bennett
Publikováno v:
The EMBO Journal
The EMBO journal 32(14), 2015-2028 (2013). doi:10.1038/emboj.2013.146
The EMBO journal 32(14), 2015-2028 (2013). doi:10.1038/emboj.2013.146
The protease β-secretase 1 (Bace1) was identified through its critical role in production of amyloid-β peptides (Aβ), the major component of amyloid plaques in Alzheimer's disease. Bace1 is considered a promising target for the treatment of this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eacd5357a8fcb5c20b9ee2cb77c09aaf
https://hdl.handle.net/21.11116/0000-000D-3620-211858/00-001M-0000-0029-26BC-9
https://hdl.handle.net/21.11116/0000-000D-3620-211858/00-001M-0000-0029-26BC-9
Autor:
Stefan F. Lichtenthaler, Qing-Xiang Amy Sang, Taheera Ferdous, Robert M. Petrovich, Bart De Strooper, Marcia L. Moss, Ina Tesseur, Gary Powell, Colin Dingwall, Jörg W. Bartsch, Bin Qi, Douglas A. Lauffenburger, Julia Li Zhong, Uwe Schlomann, Linda G. Griffith, Miles A. Miller, Mara Taverna, Lori L. Edwards, Pei Zhou
Publikováno v:
American Society for Biochemistry and Molecular Biology
The journal of biological chemistry 286(47), 40443-40451 (2011). doi:10.1074/jbc.M111.280495
The journal of biological chemistry 286(47), 40443-40451 (2011). doi:10.1074/jbc.M111.280495
Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24–204), expressed and characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f46250ec6dfd62cdd977af30f72776
http://hdl.handle.net/1721.1/76196
http://hdl.handle.net/1721.1/76196
Autor:
Harald Steiner, Nicole Höttecke, Robert Schubenel, Karlheinz Baumann, Boris Schmidt, Edith Winkler, Miriam Liebeck
Publikováno v:
Bioorganic & medicinal chemistry letters 20(9), 2958-2963 (2010). doi:10.1016/j.bmcl.2010.02.110
CK1 and gamma-secretase are interesting targets for therapeutic intervention in the treatment of cancer and Alzheimer's disease. The CK1 inhibitor IC261 was reported to inhibit gamma-secretase activity. The question is: Does CK1 inhibition directly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ddefe3909b5c0f878729ec7bb61b0d