In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin

Autor: Matteo Santoro, Walter Maetzler, Petros Stathakos, Heather L. Martin, Markus A. Hobert, Tim W. Rattay, Thomas Gasser, John V. Forrester, Daniela Berg, Kevin J. Tracey, Gernot Riedel, Peter Teismann

Publikováno v: Neurobiology of Disease
Neurobiology of disease 91, 59-68 (2016). doi:10.1016/j.nbd.2016.02.018
Neurobiology of Disease, Vol 91, Iss, Pp 59-68 (2016)

High-mobility group box 1 (HMGB1) is a nuclear and cytosolic protein that is released during tissue damage from immune and non-immune cells — including microglia and neurons. HMGB1 can contribute to progression of numerous chronic inflammatory and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4bcd188988a849bde590cba7ed6617a6
http://europepmc.org/articles/PMC4867789