Trial of Deferiprone in Parkinson’s Disease

Autor: Devos, David, Labreuche, Julien, Dušek, Petr, Post, Bart, Bloem, Bastiaan R, Berg, Daniela, Maetzler, Walter, Otto, Markus, Habert, Marie-Odile, Lehericy, Stéphane, Ferreira, Joaquim, Dodel, Richard, Rascol, Olivier, Tranchant, Christine, Eusebio, Alexandre, Thobois, Stéphane, Marques, Ana-Raquel, Meissner, Wassilios G, Ory-Magne, Fabienne, Walter, Uwe, de Bie, Rob M A, Gago, Miguel, Vilas, Dolores, Corvol, Jean-Christophe, Kulisevsky, Jaime, Januario, Cristina, Coelho, Miguel V S, Behnke, Stefanie, Worth, Paul, Seppi, Klaus, Ouk, Thavarak, Potey, Camille, Leclercq, Céline, Viard, Romain, Duhamel, Alain, Kuchcinski, Gregory, Lopes, Renaud, Pruvo, Jean-Pierre, Pigny, Pascal, Garçon, Guillaume, Simonin, Ophélie, Carpentier, Jessica, Rolland, Anne-Sophie, Nyholm, Dag, Scherfler, Christoph, Guyon Delannoy, Pauline, Mangin, Jean-François, Chupin, Marie, Bordet, Régis, Dexter, David T, Fradette, Caroline, Spino, Michael, Tricta, Fernando, Ayton, Scott, Bush, Ashley I, Devedjian, Jean-Christophe, Poewe, Werner, Duce, James A, Cabantchik, Ioav, Defebvre, Luc, Deplanque, Dominique, Moreau, Caroline, Group, FAIRPARK-II Study, Compta, Yaroslau, Pavese, Nicola, Růžička, Evžen

Publikováno v: The New England journal of medicine 387(22), 2045-2055 (2022). doi:10.1056/NEJMoa2209254
The New England Journal of Medicine, 387, 2045-2055
The New England Journal of Medicine, 387, 22, pp. 2045-2055
New England journal of medicine, 387(22), 2045-2055. Massachussetts Medical Society

Contains fulltext : 287484.pdf (Publisher’s version ) (Open Access) BACKGROUND: Iron content is increased in the substantia nigra of persons with Parkinson's disease and may contribute to the pathophysiology of the disorder. Early research suggests

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3511431d06e2ec946902f62c2163ae
https://doi.org/10.1056/nejmoa2209254

Dopamine restores reward prediction errors in old age

Autor: Peter Dayan, Quentin J. M. Huys, Raymond J. Dolan, Emrah Düzel, Rumana Chowdhury, Marc Guitart-Masip, Christian Lambert

Publikováno v: Nature reviews / Neuroscience 16(5), 648-653 (2013). doi:10.1038/nn.3364
Nature Neuroscience

Senescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fd947077a7ef24e67dc34b674cc939
https://doi.org/10.1038/nn.3364

Dopamine Modulates Episodic Memory Persistence in Old Age

Autor: Raymond J. Dolan, Marc Guitart-Masip, Emrah Düzel, Nico Bunzeck, Rumana Chowdhury

Publikováno v: The Journal of Neuroscience
The journal of neuroscience 32(41), 14193-14204 (2012). doi:10.1523/JNEUROSCI.1278-12.2012

Activation of the hippocampus is required to encode memories for new events (or episodes). Observations from animal studies suggest that, for these memories to persist beyond 4–6 h, a release of dopamine generated by strong hippocampal activation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17650710618335b2a6f25361db552508
https://doi.org/10.1523/jneurosci.1278-12.2012

Selegiline normalizes, while l-DOPA sustains the increased number of dopamine neurons in the olfactory bulb in a 6-OHDA mouse model of Parkinson's disease

Autor: Vincent Ries, Wei-Hua Chiu, Günter U. Höglinger, Thomas Carlsson, Candan Depboylu, Wolfgang H. Oertel

Publikováno v: Neuropharmacology 79, 212-221 (2014). doi:10.1016/j.neuropharm.2013.11.014

Olfactory dysfunction, often preceding the cardinal motor symptoms, such as bradykinesia, rigidity, tremor at rest and postural instability, is frequently reported in Parkinson's disease. This symptom appears to be related to an increased number of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb06837da0a057e4bcec6b811ee4c48

Strain-dependent effects of D2 dopaminergic and muscarinic-cholinergic agonists and antagonists on memory consolidation processes in mice

Autor: Ines B. Introini-Collison, Simona Cabib, Antonio Sulli, Claudio Pacitti, Claudio Castellano, Stefano Puglisi-Allegra, Antonella Gasbarri, James L. McGaugh

The interaction between muscarinic-cholinergic and dopaminergic systems in the modulation of memory storage of Y-maze discrimination (YMD) task was examined in C57BL/6 and DBA/2 strains of mice. In C57BL/6 mice, post-training systemic (i.p.) administ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e07a256eb2ea495c943733eada8e92
http://hdl.handle.net/11573/452267