The Anaesthetics Isoflurane and Xenon Reverse the Synaptotoxic Effects of Aβ1–42 on Megf10-Dependent Astrocytic Synapse Elimination and Spine Density in Ex Vivo Hippocampal Brain Slices

Autor: Dai Shi, Jaime K. Y. Wong, Kaichuan Zhu, Peter G. Noakes, Gerhard Rammes

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 912
International journal of molecular sciences 24(2), 912 (2023). doi:10.3390/ijms24020912

It has been hypothesised that inhalational anaesthetics such as isoflurane (Iso) may trigger the pathogenesis of Alzheimer’s disease (AD), while the gaseous anaesthetic xenon (Xe) exhibits many features of a putative neuroprotective agent. Loss of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155bebd27a6ac31b04fbd736e28d7ac3

Cerebral haemodynamic changes during propofol-remifentanil or sevoflurane anaesthesia: transcranial Doppler study under bispectral index monitoring

Autor: Letterio B. Santamaria, Alfredo Conti, Olivia Penna, Vincenzo Fodale, Domenico Gerardo Iacopino, S. Micalizzi

Background. Sevoflurane or propofol–remifentanil-based anaesthetic regimens represent modern techniques for neurosurgical anaesthesia. Nevertheless, there are potential differences related to their activity on the cerebrovascular system. The magnit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d1cb6d1ed0af720f4e418d662710f1
http://hdl.handle.net/11585/717658

3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities

Autor: Bruno, O., Ranise, A., Bondavalli, F., Schenone, S., michele d'amico, Falciani, M., Vacca, C., Filippelli, A.

Publikováno v: Scopus-Elsevier

The synthesis of 4-amino-3,5-diphenyl-1H-pyrazole-1-ethanol, as well as of their N-methyl, N-ethyl and N,N-dimethyl derivatives is described. A series of 1-(2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazole-4-amines and of N-substituted 4-dimethylamino-3,5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::300249477dd983daacf2d42e7a53c7ac
http://hdl.handle.net/11386/3127952

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