Zobrazeno 1 - 7
of 7
pro vyhledávání: '"pharmacology, Pyridines"'
Autor:
Günter U. Höglinger, Wolfgang Wurst, Matthias Höllerhage, Natascha Fussi, Christian Behrends, Thomas W. Rösler
Publikováno v:
Neuropharmacology 149, 13-26 (2019). doi:10.1016/j.neuropharm.2019.01.023
Pathological aggregates of alpha-synuclein are the common hallmarks of synucleinopathies, including Parkinson's disease. There is currently no disease-modifying therapy approved for neurodegenerative synucleinopathies. The induction of macroautophagy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625e929d4d566ceb29c99157505daf15
https://doi.org/10.1016/j.neuropharm.2019.01.023
https://doi.org/10.1016/j.neuropharm.2019.01.023
Autor:
Samuel Peña-Díaz, Jordi Pujols, Eftychia Vasili, Francisca Pinheiro, Jaime Santos, Zoe Manglano-Artuñedo, Tiago F. Outeiro, Salvador Ventura
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
The journal of biological chemistry 298(5), 101902 (2022). doi:10.1016/j.jbc.2022.101902
Universitat Autònoma de Barcelona
The journal of biological chemistry 298(5), 101902 (2022). doi:10.1016/j.jbc.2022.101902
Altres ajuts: ICREA (ICREA-Academia 2015 and 2020); Fundació la Marató de TV3 (20144330) Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, as well as the accumulation of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17817c7c08b0a1d4964f9661488d0571
https://doi.org/10.1016/j.jbc.2022.101902
https://doi.org/10.1016/j.jbc.2022.101902
Autor:
Tatenhorst, Lars, Eckermann, Katrin, Outeiro, Tiago F, Zweckstetter, Markus, Lingor, Paul, Dambeck, Vivian, Fonseca-Ornelas, Luis, Walle, Hagen, Lopes da Fonseca, Tomás, Koch, Jan C, Becker, Stefan, Tönges, Lars, Bähr, Mathias
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications 4(1), 39 (2016). doi:10.1186/s40478-016-0310-y
Acta Neuropathologica Communications 4(1), 39 (2016). doi:10.1186/s40478-016-0310-y
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, yet disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) was recently described as a novel neuroprotective target in PD. Since alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e25ac157886f125890f1f46489256178
https://pubmed.ncbi.nlm.nih.gov/27101974
https://pubmed.ncbi.nlm.nih.gov/27101974
A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia
Autor:
Claudia, Trenkwalder, Daniela, Berg, Olivier, Rascol, Karla, Eggert, Andres, Ceballos-Baumann, Jean-Christophe, Corvol, Alexander, Storch, Lin, Zhang, Jean-Philippe, Azulay, Emmanuel, Broussolle, Luc, Defebvre, Christian, Geny, Michal, Gostkowski, Fabrizio, Stocchi, Christine, Tranchant, Pascal, Derkinderen, Franck, Durif, Alberto J, Espay, Andrew, Feigin, Jean-Luc, Houeto, Johannes, Schwarz, Thérèse, Di Paolo, Dominik, Feuerbach, Hans-Ulrich, Hockey, Judith, Jaeger, Annamaria, Jakab, Donald, Johns, Gurutz, Linazasoro, Paul, Maruff, Izabela, Rozenberg, Judit, Sovago, Markus, Weiss, Baltazar, Gomez-Mancilla
Publikováno v:
Movement disorders 31(7), 1049-1054 (2016). doi:10.1002/mds.26569
This phase 2 randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of the nicotinic acetylcholine receptor α7 agonist AQW051 in patients with Parkinson's disease and levodopa-induced dyskinesia.Patients with idiopathic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::87d8f8277e4711a4fd7b611116e0b789
https://pub.dzne.de/record/138662
https://pub.dzne.de/record/138662
Autor:
Ralf Kühn, Caroline Nothdurfter, Theo Rein, Rainer Rupprecht, Wolfgang Wurst, Barbara Di Benedetto
Publikováno v:
Neuropharmacology 62(1), 209-216 (2012). doi:10.1016/j.neuropharm.2011.07.001
Quetiapine is an atypical antipsychotic which has been suggested to possess also antidepressant efficacy in the treatment of bipolar and unipolar depression. Recently, a link between the activation of the ERK/MAPK signalling pathway and the release o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738610c504eef86fb805c720c2bcf3b2
https://pub.dzne.de/record/136346
https://pub.dzne.de/record/136346
Autor:
Giuliana Decorti, Alessandra Pontillo, Alberto Tommasini, Luigina De Leo, Sergio Crovella, Annalisa Marcuzzi
Publikováno v:
Pediatric research. 70(1)
The shortage of geranylgeranyl-pyrophosphate (GGPP) was associated to an increased IL-1β release in the autoinflammatory syndrome mevalonate kinase deficiency (MKD), a rare inherited disease that has no specific therapy. Farnesyltransferase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708ee172c86ed347978be312ce6a78a0
https://pubmed.ncbi.nlm.nih.gov/21430599
https://pubmed.ncbi.nlm.nih.gov/21430599
Publikováno v:
Dunning, D D; Hoover, C L; Soltesz, I; Smith, M A; & O'Dowd, Diane K. (1999). GABA(A) receptor-mediated miniature postsynaptic currents and alpha-subunit expression in developing cortical neurons.. Journal of neurophysiology, 82(6), 3286-3297. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/15f257tg
Previous studies have described maturational changes in GABAergic inhibitory synaptic transmission in the rodent somatosensory cortex during the early postnatal period. To determine whether alterations in the functional properties of synaptically loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::2503837a8910c3cef74957460fe400ed
http://www.escholarship.org/uc/item/15f257tg
http://www.escholarship.org/uc/item/15f257tg