Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain

Autor: Thamyris Reis Moraes, Gislaine Ribeiro Pereira, Rafaela Figueiredo Rodrigues, Paloma Freitas dos Santos, Rodrigo Vicentino Placido, Flávia Chiva Carvalho, Sandra Barbosa Neder Agostini, Vanessa Bergamin Boralli, Giovane Galdino, Jennifer Tavares Jacon Freitas, Juliana Cancino-Bernardi, Juliana Barbosa Nunes

Publikováno v: Polymers
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Polymers, Vol 13, Iss 3837, p 3837 (2021)
Volume 13
Issue 21

This study offers a novel oral pregabalin (PG)-loaded drug delivery system based on chitosan and hypromellose phthalate-based polymeric nanocomposite in order to treat neuropathic pain (PG-PN). PG-PN has a particle size of 432 ± 20 nm, a polydispers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87f2ce914fbc14d6150c7224439afe6
http://europepmc.org/articles/PMC8587775