Zobrazeno 1 - 10
of 2 228
pro vyhledávání: '"pharmacokinetic study"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract The aim of this work is to develop and evaluate self-nanoemulsifying drug delivery systems (SNEDDS) containing simvastatin to increase its oral bioavailability. Formulation EO 5 (Ethyl oleate 9.3% w/w: Tween 80 49.4% w/w: Propylene glycol 39
Externí odkaz:
https://doaj.org/article/bea312165dee4bd0982f5993d923b4b5
Publikováno v:
BMC Veterinary Research, Vol 20, Iss 1, Pp 1-11 (2024)
Abstract As an orally effective benzimidazole anthelmintic agent, fenbendazole was not only widely used in agriculture and animal husbandry to prevent and treat parasites, but also shows anti-cancer effects against several types of cancer, exhibits a
Externí odkaz:
https://doaj.org/article/58b5298b25814c7eb4127460e08aa4c2
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33234- (2024)
The pharmacological effects of flavonoids in Oroxylum indicum (L.) Kurz against inflammation, bacterial, and oxidation have been well-documented. Additionally, it is commonly consumed as tea. However, the in vivo mechanism of its main compounds has n
Externí odkaz:
https://doaj.org/article/c459574dd43c44deab13ae9cde70cd15
Publikováno v:
Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 31, Iss , Pp 27-32 (2024)
Introduction: A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for estimation of bedaquiline (BDQ) in human plasma using the deuterated analogue of the analyte, bedaquiline-d6 (BDQ-d6) as the internal standar
Externí odkaz:
https://doaj.org/article/9b3a0924544944dca8dee86e9960318a
Publikováno v:
Medicina, Vol 60, Iss 10, p 1686 (2024)
Background and Objectives: Seliciclib (SEL) is the first selective, orally bioavailable potential drug containing cyclin-dependent kinase inhibitors. Preclinical studies showed antitumor activity in a broad range of human tumor xenografts, neurodegen
Externí odkaz:
https://doaj.org/article/1c97c6a0f761404ab650bdcb124e166e
Publikováno v:
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Vol 11, Iss 1, Pp 132-142 (2023)
A modified-release dexamphetamine sulfate formulation (DEX-MR) is under development for the treatment of attention-deficit/hyperactivity disorder.
Externí odkaz:
https://doaj.org/article/5716f3a144484ccd91fce8b90c5b258f
Publikováno v:
Al-Mustansiriyah Journal of Pharmaceutical Sciences, Vol 24, Iss 1 (2024)
Lung cancer is the most prevalent worldwide. In addition, it is also the most common cause of cancer-related deaths worldwide, with around 1.8 million new cases annually. With a 5-year survival rate of fewer than 20%. Cytotoxic medicines are common
Externí odkaz:
https://doaj.org/article/07b4760edc8244fcbb4c2481fc6ba864
Autor:
Mahmoud A. A. Ibrahim, Sara S. M. Ali, Khlood A. A. Abdeljawaad, Alaa H. M. Abdelrahman, Gamal A. Gabr, Ahmed M. Shawky, Gamal A. H. Mekhemer, Peter A. Sidhom, Paul W. Paré, Mohamed-Elamir F. Hegazy
Publikováno v:
Journal of Taibah University for Science, Vol 17, Iss 1 (2023)
In the search for new metabolite inhibitors, a natural product activity and species source (NPASS) database was virtually screened using AutoDock software to identify potential NRP1 inhibitors. NPASS compounds complexed with NRP1 were subjected to mo
Externí odkaz:
https://doaj.org/article/220d62db63ee48d4affea6ff1e339d03
Autor:
Eman Gomaa, Noura G. Eissa, Tarek M. Ibrahim, Hany M. El-Bassossy, Hanan M. El-Nahas, Margrit M. Ayoub
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 4, Pp 499-509 (2023)
High percentage of diabetic people are diagnosed as type 2 who require daily dosing of an antidiabetic drug such as Linagliptin (Lina) to manage their blood glucose levels. This study aimed to develop injectable Lina-loaded biodegradable poly (lactic
Externí odkaz:
https://doaj.org/article/35317966c12945cd8c90eb9f9f2f2cb5