Zobrazeno 1 - 10
of 108
pro vyhledávání: '"pharmacoepigenomics"'
Publikováno v:
Pharmacological Research, Vol 205, Iss , Pp 107247- (2024)
About 80 % of brain disorders have a genetic basis. The pathogenesis of most neurodegenerative diseases is associated with a myriad of genetic defects, epigenetic alterations (DNA methylation, histone/chromatin remodeling, miRNA dysregulation), and e
Externí odkaz:
https://doaj.org/article/4d97885196c74d7bb0aa63ff0436548f
Publikováno v:
Cambridge Prisms: Precision Medicine, Vol 1 (2023)
Pharmacogenetics, the study of how interindividual genetic differences affect drug response, does not explain all observed heritable variance in drug response. Epigenetic mechanisms, such as DNA methylation, and histone acetylation may account for so
Externí odkaz:
https://doaj.org/article/3004e3bfe00d426ab1348b4eab52dc41
Autor:
Huihui Du, Jingsong Ma, Wei Zhou, Mo Li, Cong Huai, Lu Shen, Hao Wu, Xianglong Zhao, Na Zhang, Songyin Gao, Qi Wang, Lin He, Xuming Wu, Shengying Qin, Mingzhe Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Accumulating evidence shows that DNA methylation plays a role in antipsychotic response. However, the mechanisms by which DNA methylation changes are associated with antipsychotic responses remain largely unknown.Methods: We performed a m
Externí odkaz:
https://doaj.org/article/17f16ad3191f4808a85d878dda0e8665
Akademický článek
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Autor:
Babu Swathy, Moinak Banerjee
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Interindividual variability in drug response is a major concern among patients undergoing antipsychotic drug treatment. Apart from genetic and physiological factors, this variability in drug response could also be attributed to epigenetic mechanisms.
Externí odkaz:
https://doaj.org/article/6ee7a2110c9846498975d72c665e7566
Autor:
Leila Mazdai, Matteo Fabbri, Micaela Tirri, Giorgia Corli, Raffaella Arfè, Beatrice Marchetti, Sabrine Bilel, Eva Bergamin, Rosa Maria Gaudio, Michele Rubini, Fabio De-Giorgio, Matteo Marti
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1398 (2022)
In the recent decade, numerous new psychoactive substances (NPSs) have been added to the illicit drug market. These are synthetized to mimic the effects of classic drugs of abuse (i.e., cannabis, cocaine, etc.), with the purpose of bypassing substanc
Externí odkaz:
https://doaj.org/article/9f5aa959ee4e40a5bfcb83667003f9b7
Autor:
Ramón Cacabelos, Clara Torrellas
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 12, Pp 30483-30543 (2015)
Epigenetic variability (DNA methylation/demethylation, histone modifications, microRNA regulation) is common in physiological and pathological conditions. Epigenetic alterations are present in different tissues along the aging process and in neurodeg
Externí odkaz:
https://doaj.org/article/52803c206ec347d8a92634fb273a4210
Publikováno v:
Pharmaceutics, Vol 11, Iss 3, p 126 (2019)
Fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are diseases of unknown etiology presenting complex and often overlapping symptomatology. Despite promising advances on the study of miRNomes of these diseases, no vali
Externí odkaz:
https://doaj.org/article/3e32f8612759468698d747116c8aaba6
Autor:
Xiaojian Shao, Catherine Le Stunff, Warren Cheung, Tony Kwan, Mark Lathrop, Tomi Pastinen, Pierre Bougnères
Background Recombinant human growth hormone (rhGH) has shown a great growth-promoting potential in children with idiopathic short stature (ISS). However, the response to rhGH differs across individuals, largely due to genetic and epigenetic heterogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b26cb50e0609c73d068966bcbd32d2
https://nrc-publications.canada.ca/eng/view/object/?id=7be8496c-ce81-435f-9b6b-28fe9dfdf3b5
https://nrc-publications.canada.ca/eng/view/object/?id=7be8496c-ce81-435f-9b6b-28fe9dfdf3b5
Akademický článek
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