Zobrazeno 1 - 10
of 1 101
pro vyhledávání: '"pharmacodynamic model"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
AST-001, a novel syrup formulation of L-serine, was developed for the treatment of autism spectrum disorders (ASD) in pediatric patients. This study aimed to establish a pharmacokinetic (PK)-pharmacodynamic (PD) model to elucidate the effect of AST-0
Externí odkaz:
https://doaj.org/article/2a0587063d494088b6d00cf2fb4987c6
Autor:
Nan Xu, Muhammad Ijaz, Yishuo Shu, Peng Wang, Lei Ma, Ping Wang, Hailing Ding, Muhammad Shahbaz, Haiyan Shi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Wendan Decoction (WDD) is a six-herb Chinese medicine recipe that was first mentioned in about 652 AD. It is frequently used to treat hyperlipidemic patients’ clinical complaints. According to reports, oxidative stress has a significant
Externí odkaz:
https://doaj.org/article/f50f79fc9901405cb3f62197bc9877a9
Publikováno v:
Frontiers in Systems Biology, Vol 3 (2024)
Computational models of disease progression have been constructed for a myriad of pathologies. Typically, the conceptual implementation for pathology-related in silico intervention studies has been ad hoc and similar in design to experimental studies
Externí odkaz:
https://doaj.org/article/86874475a14645c9a49b4ee563927aac
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Purpose: In order to support the dose optimization of zoledronic acid, the kinetic-pharmacodynamic model and exposure-response analysis were used to describe the changes in bone mineral density in different doses of zoledronic acid and establish the
Externí odkaz:
https://doaj.org/article/5830021e478b4e6198b0dadf159fc5c5
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/d5920a9bb6ff49aba158ee07e0507907
Publikováno v:
Axioms, Vol 12, Iss 9, p 867 (2023)
We obtain an analytical solution for the time-optimal control problem in the induction phase of anesthesia. Our solution is shown to align numerically with the results obtained from the conventional shooting method. The induction phase of anesthesia
Externí odkaz:
https://doaj.org/article/f19b91834caa45e79fd7b5113d873e39
Publikováno v:
Engineering Microbiology, Vol 2, Iss 2, Pp 100021- (2022)
The increasing antimicrobial resistance has seriously threatened human health worldwide over the last three decades. This severe medical crisis and the dwindling antibiotic discovery pipeline require the development of novel antimicrobial treatments
Externí odkaz:
https://doaj.org/article/2b1ca77b792846dcb2a6d012abae0068
Heterogeneity in Vaccinal Immunity to SARS-CoV-2 Can Be Addressed by a Personalized Booster Strategy
Autor:
Madison Stoddard, Lin Yuan, Sharanya Sarkar, Shruthi Mangalaganesh, Ryan P. Nolan, Dean Bottino, Greg Hather, Natasha S. Hochberg, Laura F. White, Arijit Chakravarty
Publikováno v:
Vaccines, Vol 11, Iss 4, p 806 (2023)
SARS-CoV-2 vaccinations were initially shown to substantially reduce risk of severe disease and death. However, pharmacokinetic (PK) waning and rapid viral evolution degrade neutralizing antibody (nAb) binding titers, causing loss of vaccinal protect
Externí odkaz:
https://doaj.org/article/96a245fc87ee4429b1fd2755184c4612