Zobrazeno 1 - 10
of 433
pro vyhledávání: '"pharmaceutical solids"'
Publikováno v:
IUCrJ, Vol 11, Iss 1, Pp 23-33 (2024)
Fatty acid-derivative prodrugs have been utilized extensively to improve the physicochemical, biopharmaceutical and pharmacokinetic properties of active pharmaceutical ingredients. However, to our knowledge, the crystallization behavior of prodrugs m
Externí odkaz:
https://doaj.org/article/92fca16d592d4a1c8acfa3a96e741490
Publikováno v:
IUCrJ, Vol 9, Iss 3, Pp 370-377 (2022)
Water confined or constrained in a cellular environment can exhibit a diverse structural and dynamical role and hence will affect the self-assembly behavior of biomolecules. Herein, the role of water in the formation of l-phenylalanine crystals and a
Externí odkaz:
https://doaj.org/article/83466d1998724e9ea95571d8e66155a3
Publikováno v:
IUCrJ, Vol 8, Iss 4, Pp 584-594 (2021)
Understanding of solid-to-solid phase transition mechanisms in polymorphic systems is of critical importance for rigorous control over polymorph purity in the pharmaceutical industry to achieve the desired bioavailability and efficacy of drugs. Ubiqu
Externí odkaz:
https://doaj.org/article/0343a6b47f1548478b30ad043d6000b4
Autor:
Vivek Verma, Simone Bordignon, Michele R. Chierotti, Monica Lestari, Kieran Lyons, Luis Padrela, Kevin M. Ryan, Matteo Lusi
Publikováno v:
IUCrJ, Vol 7, Iss 6, Pp 1124-1130 (2020)
Multidrug products enable more effective therapies and simpler administration regimens, provided that a stable formulation is prepared, with the desired composition. In this view, solid solutions have the advantage of combining the stability of a sin
Externí odkaz:
https://doaj.org/article/ecbf8e7fceab46978d920b4198abe11f
Publikováno v:
IUCrJ, Vol 7, Iss 1, Pp 105-112 (2020)
Co-crystallization is a phenomenon widely employed to enhance the physio-chemical and biological properties of active pharmaceutical ingredients (APIs). Exemestane, or 6-methylideneandrosta-1,4-diene-3,17-dione, is an anabolic steroid used as an irre
Externí odkaz:
https://doaj.org/article/bb56bd087a034c59b7a7f10fb15c5008
Autor:
Cristóbal Verdugo-Escamilla, Carolina Alarcón-Payer, Francisco Javier Acebedo-Martínez, Raquel Fernández-Penas, Alicia Domínguez-Martín, Duane Choquesillo-Lazarte
Publikováno v:
Crystals, Vol 12, Iss 6, p 798 (2022)
In this investigation, three new crystal forms of lidocaine, and another three of lidocaine hydrochloride with hydroquinone, resorcinol, and pyrogallol were synthetised. All the new forms were characterised using multiple techniques, PXRD, SC-XRD, DS
Externí odkaz:
https://doaj.org/article/beee7a3c08a9497690da2d7e673ea82e
Akademický článek
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Publikováno v:
IUCrJ, Vol 5, Iss 4, Pp 449-469 (2018)
This paper presents experimental charge-density studies of cytosinium chloride, adeninium chloride hemihydrate and guaninium dichloride crystals based on ultra-high-resolution X-ray diffraction data and extensive theoretical calculations. The results
Externí odkaz:
https://doaj.org/article/c045efbd0c85492cbb8d8762de344283
Publikováno v:
Molecules, Vol 26, Iss 15, p 4427 (2021)
Inclusion complexes between cyclodextrins (CDs) and active pharmaceutical ingredients (APIs) have potential for pharmaceutical formulation. Since crystallization of a given complex may result in the isolation of multiple crystal forms, it is essentia
Externí odkaz:
https://doaj.org/article/77abae2f3f0e49b7bc57c3f953730919
Autor:
Geetha Bolla, Ashwini Nangia
Publikováno v:
IUCrJ, Vol 3, Iss 2, Pp 152-160 (2016)
A novel design strategy for cocrystals of a sulfonamide drug with pyridine carboxamides and cyclic amides is developed based on synthon identification as well as size and shape match of coformers. Binary adducts of acetazolamide (ACZ) with lactams (v
Externí odkaz:
https://doaj.org/article/5ef308044f734326b0975c3b48e74113