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Akademický článek

Comparison of prevalence estimates of pfhrp2 and pfhrp3 deletions in Plasmodium falciparum determined by conventional PCR and multiplex qPCR and implications for surveillance and monitoring

Autor: Michelle L. Gatton, David Smith, Cielo Pasay, Karen Anderson, Selam Mihreteab, Hugo O. Valdivia, Juan F. Sanchez, Khalid B. Beshir, Jane Cunningham, Qin Cheng

Publikováno v: International Journal of Infectious Diseases, Vol 144, Iss , Pp 107061- (2024)

Objectives: The accuracy of malaria rapid diagnostic tests is threatened by Plasmodium falciparum with pfhrp2/3 deletions. This study compares gene deletion prevalence determined by multiplex real time polymerase chain reaction (qPCR) and conventiona

Externí odkaz: https://doaj.org/article/f79bf97ed505439597db3c774d2a58d2

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Akademický článek

Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility of HRP2-based malaria RDTs in Northern Uganda

Autor: Bosco B. Agaba, David Smith, Jye Travis, Cielo Pasay, Monica Nabatanzi, Emmanuel Arinaitwe, Isaac Ssewanyana, Susan Nabadda, Jane Cunningham, Moses R. Kamya, Qin Cheng

Publikováno v: Malaria Journal, Vol 23, Iss 1, Pp 1-9 (2024)

Abstract Background Rapid diagnostic tests (RDTs) that detect Plasmodium falciparum histidine-rich protein-2 (PfHRP2) are exclusively deployed in Uganda, but deletion of the pfhrp2/3 target gene threatens their usefulness as malaria diagnosis and sur

Externí odkaz: https://doaj.org/article/fb437d6468c54ea1b80bc63f5c0f3c6d

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Akademický článek

Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions and Relatedness to Other Global Isolates, Djibouti, 2019–2020

Autor: Eric Rogier, Jessica N. McCaffery, Mohamed Ali Mohamed, Camelia Herman, Doug Nace, Rachel Daniels, Naomi Lucchi, Sophie Jones, Ira Goldman, Michael Aidoo, Qin Cheng, Edie A. Kemenang, Venkatachalam Udhayakumar, Jane Cunningham

Publikováno v: Emerging Infectious Diseases, Vol 28, Iss 10, Pp 2043-2050 (2022)

Deletions of pfhrp2 and paralogue pfhrp3 (pfhrp2/3) genes threaten Plasmodium falciparum diagnosis by rapid diagnostic test. We examined 1,002 samples from suspected malaria patients in Djibouti City, Djibouti, to investigate pfhrp2/3 deletions. We p

Externí odkaz: https://doaj.org/article/680d93b15c334582b9209376fec4e42b

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Akademický článek

Screening strategies and laboratory assays to support Plasmodium falciparum histidine-rich protein deletion surveillance: where we are and what is needed

Autor: Khalid B. Beshir, Jonathan B. Parr, Jane Cunningham, Qin Cheng, Eric Rogier

Publikováno v: Malaria Journal, Vol 21, Iss 1, Pp 1-12 (2022)

Abstract Rapid diagnostic tests (RDTs) detecting Plasmodium falciparum histidine-rich protein 2 (HRP2) have been an important tool for malaria diagnosis, especially in resource-limited settings lacking quality microscopy. Plasmodium falciparum parasi

Externí odkaz: https://doaj.org/article/8dd54b7169c74c5c9f2e77594a223096

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Akademický článek

Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions from Persons with Symptomatic Malaria Infection in Ethiopia, Kenya, Madagascar, and Rwanda

Autor: Eric Rogier, Jessica N. McCaffery, Doug Nace, Samaly Souza Svigel, Ashenafi Assefa, Jimee Hwang, Simon Kariuki, Aaron M. Samuels, Nelli Westercamp, Arsène Ratsimbasoa, Milijaona Randrianarivelojosia, Aline Uwimana, Venkatachalam Udhayakumar, Eric S. Halsey

Publikováno v: Emerging Infectious Diseases, Vol 28, Iss 3, Pp 608-616 (2022)

Histidine-rich protein 2 (HRP2)–based rapid diagnostic tests detect Plasmodium falciparum malaria and are used throughout sub-Saharan Africa. However, deletions in the pfhrp2 and related pfhrp3 (pfhrp2/3) genes threaten use of these tests. Therapeu

Externí odkaz: https://doaj.org/article/4999e2a0296642fd9963d330b40d312c

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Akademický článek

Low frequency of Plasmodium falciparum hrp2/3 deletions from symptomatic infections at a primary healthcare facility in Kilifi, Kenya

Autor: Dorcas Okanda, Leonard Ndwiga, Victor Osoti, Nicole Achieng, Juliana Wambua, Caroline Ngetsa, Peter Lubell-Doughtie, Anuraj Shankar, Philip Bejon, Lynette Isabella Ochola-Oyier

Publikováno v: Frontiers in Epidemiology, Vol 3 (2023)

There is a growing concern for malaria control in the Horn of Africa region due to the spread and rise in the frequency of Plasmodium falciparum Histidine-rich Protein (hrp) 2 and 3 deletions. Parasites containing these gene deletions escape detectio

Externí odkaz: https://doaj.org/article/b4b7e85893404b789f6db4ff1d20f850

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Akademický článek

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Akademický článek

Genetic variation of Plasmodium falciparum histidine-rich protein 2 and 3 in Assosa zone, Ethiopia: its impact on the performance of malaria rapid diagnostic tests

Autor: Gezahegn Solomon Alemayehu, Alebachew Messele, Kayla Blackburn, Karen Lopez, Eugenia Lo, Daniel Janies, Lemu Golassa

Publikováno v: Malaria Journal, Vol 20, Iss 1, Pp 1-13 (2021)

Abstract Background Rapid diagnostic tests (RDT) are commonly used for the diagnosis of malaria caused by Plasmodium falciparum. However, false negative results of RDT caused by genetic variation of P. falciparum histidine-rich protein 2 and 3 genes

Externí odkaz: https://doaj.org/article/1f07898ec8654567828a8dfe066b9c68

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