Zobrazeno 1 - 10
of 3 065
pro vyhledávání: '"peroxisome proliferator-activated receptor alpha"'
Autor:
Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata
Publikováno v:
Endocrine Journal, Vol 71, Iss 11, Pp 1055-1067 (2024)
We previously demonstrated hepatic, cardiac, and skin inflammation in a high-fat diet-induced steatotic liver disease (SLD) model. However, the molecular mechanism in the kidneys in this model remains unclear. It has been recently reported that SGLT2
Externí odkaz:
https://doaj.org/article/c8547725ada84510b6ac63c3efbd6bcb
Autor:
Shiguan Wang, Bowen Xu, Jinyuan Liang, Yawei Feng, Penghu Han, Jing Shen, Xinying Li, Mengqi Zheng, Tingguo Zhang, Cuijuan Zhang, Ping Mi, Yi Zhang, Zhiping Liu, Shiyang Li, Detian Yuan
Publikováno v:
Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)
Abstract Spatial heterogeneity and plasticity of the mammalian liver are critical for systemic metabolic homeostasis in response to fluctuating nutritional conditions. Here, a spatially resolved transcriptomic landscape of mouse livers across fed, fa
Externí odkaz:
https://doaj.org/article/86ae09b61b4a4b199f6a6a5d1138824c
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e38648- (2024)
Background: Shenmai injection (SMI), a traditional Chinese medicine formulation derived from the herbal decoction Shenmai Yin, is widely used in treating cardiovascular disorders. This study extensively investigated the effects and mechanisms of acti
Externí odkaz:
https://doaj.org/article/2a16533244ca4fdfae9938bb6cd3b8bf
Autor:
Riccardo Bortoletto, Fabiana Piscitelli, Marta Basaldella, Claudia Scipioni, Carla Comacchio, Roberta Fiorino, Stefano Fornasaro, Pierluigi Barbieri, Daniele Pagliaro, Orietta Sepulcri, Martina Fabris, Francesco Curcio, Matteo Balestrieri, Marco Colizzi
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Despite promise of its supplementation as both monotherapy and add-on treatment in autism spectrum disorder (ASD), the biobehavioral effects of Palmitoylethanolamide (PEA) in autistic adults have never been explored so far. We discussed the cases of
Externí odkaz:
https://doaj.org/article/450b444e6214445cb93a6b708d4f1089
Publikováno v:
The European Chemistry and Biotechnology Journal, Iss 2 (2024)
Aging unfolds as a complex process marked by numerous physiological and biochemical transformations. These age-related changes intricately influence tissues, cells, and subcellular organelles, thereby impacting metabolic functions. Dyslipidemia, char
Externí odkaz:
https://doaj.org/article/571d68939eb04fc5bac5650cec0823dd
Autor:
Christopher D. Radka, Matthew W. Frank, Tyler S. Simmons, Cydney N. Johnson, Jason W. Rosch, Charles O. Rock
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Commensal gut bacteria use oleate hydratase to release a spectrum of hydroxylated fatty acids using host-derived unsaturated fatty acids. These compounds are thought to attenuate the immune response, but the underlying signaling mechanism(s) remain t
Externí odkaz:
https://doaj.org/article/70f3502acdec48fe9505c1796b4179e0
Autor:
Barbara J. Mason, David Estey, Amanda Roberts, Giordano de Guglielmo, Olivier George, John Light, Mike Stoolmiller, Susan Quello, Michael Skinner, Farhad Shadan, Adnan Begovic, Mark C. Kyle, R. Adron Harris
Publikováno v:
Neurobiology of Stress, Vol 29, Iss , Pp 100604- (2024)
Alcohol Use Disorder (AUD) is a chronic relapsing disorder affecting an estimated 283 million individuals worldwide, with substantial health and economic consequences. Peroxisome proliferator-activated receptors (PPARs), particularly PPAR-α and PPAR
Externí odkaz:
https://doaj.org/article/d712f48a4d8d46ca9c970201760b2cc2
Autor:
Xitong Yang, Guangming Wang
Publikováno v:
Acta Cirúrgica Brasileira, Vol 38 (2023)
ABSTRACT Purpose: Cerebral ischemia-reperfusion (I/R) is a neurovascular disorder that leads to brain injury. In mice, Fasudil improves nerve injury induced by I/R. However, it is unclear if this is mediated by increased peroxisome proliferator-activ
Externí odkaz:
https://doaj.org/article/859959163b874a1994c0fc38b8e88ba7
Autor:
Ling He, Xiangjun Zhou, Jia Liu, Yina Yao, Junyuan Lin, Jialong Chen, Shizhen Qiu, Zeyu Liu, Yingzheng He, Yujie Yi, Xueqiong Zhou, Fei Zou
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 265, Iss , Pp 115513- (2023)
Abstractc: Esophageal cancer (EC) is the sixth cause of cancer-related deaths and still is a significant public health problem globally. Nitrosamines exposure represents a major health concern increasing EC risks. Exploring the mechanisms induced by
Externí odkaz:
https://doaj.org/article/f7b4640cddd646018470b691f2d01bb7
Autor:
Alireza Nikoozadeh, Roghayeh Pouzesh-Jadidi, Alireza Nourazar, Masoud Asgharpour-Arshad, Jabar Bashiri
Publikováno v:
Fiyz̤, Vol 26, Iss 4, Pp 398-406 (2022)
Background: Mitochondrial dysfunction is one of the possible mechanisms for the progression of heart disease. This study aimed to effect of eight weeks of aerobic training and curcumin supplementation on PGC1- α gene expression and cardiomyocyte mit
Externí odkaz:
https://doaj.org/article/be9d765365864a4aaf79aeaeb64a64ec