Zobrazeno 1 - 10
of 208
pro vyhledávání: '"peripheral immune system"'
Autor:
Adhikary Krishnendu, Mohanty Satyajit, Bandyopadhyay Bidyut, Maiti Rajkumar, Bhattacharya Koushik, Karak Prithviraj
Publikováno v:
Biomolecular Concepts, Vol 15, Iss 1, Pp 241-52 (2024)
Alzheimer’s disease (AD) is characterized by immune system dysregulation, impacting both central and peripheral immune responses. The study aimed to investigate the mechanism behind the neurotoxic effects of β-amyloid (Aβ) peptide in the rat brai
Externí odkaz:
https://doaj.org/article/1db6af33753f46bead6b58ef577add52
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Neuroinflammation has been identified as another significant pathogenic factor in Alzheimer’s disease following Aβ amyloid deposition and tau protein hyperphosphorylation, activated in the central nervous system by glial cells in response to injur
Externí odkaz:
https://doaj.org/article/c9d249ae0af34699839bc17fa567d05b
Autor:
Elizabeth B. Engler-Chiurazzi, Wesley H. Chastain, Kailen K. Citron, Lillian E. Lambert, Divya N. Kikkeri, Sharhana S. Shrestha
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Major depression is a significant medical issue impacting millions of individuals worldwide. Identifying factors contributing to its manifestation has been a subject of intense investigation for decades and several targets have emerged including sex
Externí odkaz:
https://doaj.org/article/6eb2d250009d431eae8a8743f9df50ca
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
For decades, it has been widely believed that the blood–brain barrier (BBB) provides an immune privileged environment in the central nervous system (CNS) by blocking peripheral immune cells and humoral immune factors. This view has been revised in
Externí odkaz:
https://doaj.org/article/2783c89a096b4e8291e163c5b7026fa8
Publikováno v:
Frontiers in Neurology, Vol 12 (2022)
Central nervous system (CNS) infections remain a major burden of pediatric disease associated with significant long-term morbidity due to injury to the developing brain. Children are susceptible to various etiologies of CNS infection partly because o
Externí odkaz:
https://doaj.org/article/1141db979ae64785952ce114001be94d
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/460a06051b2943c1a578507f970de8d7
Autor:
Iulia-Diana Stanca, Oana Criciotoiu, Simona-Daniela Neamtu, Ramona-Constantina Vasile, Nicoleta-Madalina Berceanu-Bora, Teodora-Nicoleta Minca, Ionica Pirici, Gabriela-Camelia Rosu, Simona Bondari
Publikováno v:
Healthcare, Vol 10, Iss 12, p 2578 (2022)
Parkinson’s disease is a chronic, progressive, and neurodegenerative disease, and yet with an imprecise etiopathogenesis. Although neuroinflammation was initially thought to be a secondary condition, it is now believed that microglia-induced inflam
Externí odkaz:
https://doaj.org/article/db368119cfe24f84b09798691f17630a
Publikováno v:
Life, Vol 12, Iss 9, p 1440 (2022)
Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder and is the most common cause of dementia. Furthermore, aging is considered the most critical risk factor for AD. However, despite the vast amount of research and resources alloc
Externí odkaz:
https://doaj.org/article/6ac94c72a827402eaec5972e4a71a72a
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 19, p 5543 (2022)
Lymphocyte count and neutrophil-to-lymphocyte ratio (NLR) may represent useful biomarkers of Parkinson’s disease (PD), but their role in PD-related mild cognitive impairment (MCI) has not been fully elucidated. The present study aimed to confirm wh
Externí odkaz:
https://doaj.org/article/0b879ad4ddcd4a65a8c411832f02b657
Autor:
Ágatha Oliveira-Giacomelli, Lyvia Lintzmaier Petiz, Roberta Andrejew, Natalia Turrini, Jean Bezerra Silva, Ulrich Sack, Henning Ulrich
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the extensive release of ATP induces sustained P2X7 receptor activation, culminating in induction of proinflammatory pathways with inflammasome assembly and cytoki
Externí odkaz:
https://doaj.org/article/92e626a96c48441683565818b7651328