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pro vyhledávání: '"peptidylarginine deiminases (PADs)"'
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Autor:
Tania Colasanti, Francesca Romana Spinelli, Cristiana Barbati, Fulvia Ceccarelli, Susanna Scarpa, Marta Vomero, Cristiano Alessandri, Guido Valesini, Fabrizio Conti
Publikováno v:
Cells, Vol 11, Iss 2, p 262 (2022)
Belimumab (BLM) is a B lymphocyte stimulator (BLyS) inhibitor approved for the treatment of systemic lupus erythematosus (SLE). Autophagy is a cell survival mechanism involved in the pathogenesis of SLE. Citrullination is a post-translational modific
Externí odkaz:
https://doaj.org/article/366529d38701421195e3396a1b224ad4
Publikováno v:
Biology, Vol 9, Iss 1, p 15 (2020)
Pelagic seabirds are amongst the most threatened of all avian groups. They face a range of immunological challenges which seem destined to increase due to environmental changes in their breeding and foraging habitats, affecting prey resources and exp
Externí odkaz:
https://doaj.org/article/ff6ee015d5354393bcbd4ffcdd772717
Autor:
Pinar Uysal-Onganer, Vilhjálmur Svansson, Karl Skírnisson, Bergljót Magnadóttir, Igor Kraev, Sigrun Lange
Publikováno v:
Biochimie. :79-90
Peptidylarginine deiminases (PADs) are phylogenetically conserved calcium-dependent enzymes which post-translationally convert arginine into citrulline in target proteins in an irreversible manner, leading to functional and structural changes in targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd275b7fc832e47b28bc6723c7902f6b
https://doi.org/10.1016/j.biochi.2020.02.017
https://doi.org/10.1016/j.biochi.2020.02.017
Autor:
Oskar Ciesielski, Marta Biesiekierska, Baptiste Panthu, Mirosław Soszyński, Luciano Pirola, Aneta Balcerczyk
Publikováno v:
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2022, 79 (2), pp.94. ⟨10.1007/s00018-022-04126-3⟩
Cellular and Molecular Life Sciences, 2022, 79 (2), pp.94. ⟨10.1007/s00018-022-04126-3⟩
Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell through altering the structure and functions of proteins. The action of the most prevalent PTMs, encompassing phosphorylation, methylation, acylations, ubiqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e3923f911965fadb0f223920587bcb
https://doi.org/10.1007/s00018-022-04126-3
https://doi.org/10.1007/s00018-022-04126-3
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1396, p 1396 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences
Volume 22
Issue 3
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with limited survival rate. Roles for peptidylarginine deiminases (PADs) have been studied in relation to a range of cancers with roles in epigenetic regulation (inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0551abedd7a691cd2b3e3ce1cbe4c3b
https://www.mdpi.com/1422-0067/22/3/1396
https://www.mdpi.com/1422-0067/22/3/1396
Publikováno v:
International Journal of Molecular Sciences
The bovine immune system is known for its unusual traits relating to immunoglobulin and antiviral responses. Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that cause post-translational deimination, contributing to protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c35a69e2fd233ef31170b09935c74bfe
https://pubmed.ncbi.nlm.nih.gov/32325910
https://pubmed.ncbi.nlm.nih.gov/32325910
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2743, p 2743 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 8
International Journal of Molecular Sciences
Volume 21
Issue 8
The identification of biomarkers for early diagnosis of Parkinson&rsquo
s disease (PD) is of pivotal importance for improving approaches for clinical intervention. The use of translatable animal models of pre-motor PD therefore offers optimal op
s disease (PD) is of pivotal importance for improving approaches for clinical intervention. The use of translatable animal models of pre-motor PD therefore offers optimal op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25079d3a08a6012a453e3407871e2925
https://www.mdpi.com/1422-0067/21/8/2743
https://www.mdpi.com/1422-0067/21/8/2743
Autor:
Sigrun Lange, Pinar Uysal-Onganer, Amy MacLatchy, Paul R. Thompson, Rayan Mahmoud, Igor Kraev, Jameel M. Inal
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 4
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1495 (2020)
Volume 21
Issue 4
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1495 (2020)
Glioblastoma multiforme (GBM) is an aggressive adult brain tumour with poor prognosis. Roles for peptidylarginine deiminases (PADs) in GBM have recently been highlighted. Here, two GBM cell lines were treated with PAD2, PAD3 and PAD4 isozyme-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742a57826103d6de53cc68e4a7d7abe5
http://oro.open.ac.uk/69483/1/ijms-21-01495.pdf
http://oro.open.ac.uk/69483/1/ijms-21-01495.pdf
Publikováno v:
Biology
Volume 9
Issue 1
Biology, Vol 9, Iss 1, p 15 (2020)
Volume 9
Issue 1
Biology, Vol 9, Iss 1, p 15 (2020)
Pelagic seabirds are amongst the most threatened of all avian groups. They face a range of immunological challenges which seem destined to increase due to environmental changes in their breeding and foraging habitats, affecting prey resources and exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340b433f05b5c5b3205ca3907b0a786b