A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke

Autor: Brett A. Eyford, Chaahat S. B. Singh, Thomas Abraham, Lonna Munro, Kyung Bok Choi, Tracy Hill, Rhonda Hildebrandt, Ian Welch, Timothy Z. Vitalis, Reinhard Gabathuler, Jacob A. Gordon, Hans Adomat, Emma S.T. Guns, Chieh-Ju Lu, Cheryl G. Pfeifer, Mei Mei Tian, Wilfred A. Jefferies

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

The blood-brain barrier (BBB) hinders the distribution of therapeutics intended for treatment of neuroinflammation (NI) of the central nervous system. A twelve-amino acid peptide that transcytoses the BBB, termed MTfp, was chemically conjugated to si

Externí odkaz: https://doaj.org/article/a03a0a8be37540beb76b28f2d46208c8

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Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer

Autor: Natalia A. Kolganova, Vladimir B. Tsvetkov, Andrey A. Stomakhin, Sergei A. Surzhikov, Edward N. Timofeev, Irina V. Varizhuk

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8406

Modification of DNA aptamers is aimed at increasing their thermodynamic stability, and improving affinity and resistance to biodegradation. G-quadruplex DNA aptamers are a family of affinity ligands that form non-canonical DNA assemblies based on a G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04975da8ed4a74b7aa3ff25ee1f7d17
https://doi.org/10.3390/ijms24098406

Peptide Assembly Directed and Quantified Using Megadalton DNA Nanostructures

Autor: Christopher W. Wood, Juan Jin, Jonathan Bath, Andrew J. Turberfield, Emily G. Baker, Derek N. Woolfson

Publikováno v: ACS Nano
Jin, J, Baker, E, Wood, C, Bath, J, Woolfson, D & Tuberfield, A 2019, ' Peptide Assembly Directed and Quantified Using Megadalton DNA Nanostructures ', ACS Nano . https://doi.org/10.1021/acsnano.9b04251
Jin, J, Baker, E G, Wood, C W, Bath, J, Woolfson, D N & Turberfield, A J 2019, ' Peptide assembly directed and quantified using megadalton DNA nanostructures ', ACS Nano, vol. 13, no. 9, pp. 9927-9935 . https://doi.org/10.1021/acsnano.9b04251

In nature, co-assembly of polypeptides, nucleic acids, and polysaccharides is used to create functional supramolecular structures. Here, we show that DNA nanostructures can be used to template interactions between peptides and to enable the quantific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae252b383a1a50024e7c46d64eab650b
https://pubmed.ncbi.nlm.nih.gov/31381314

Synthesis of a Peptide-Human Telomere DNA Conjugate as a Fluorometric Imaging Reagent for Biological Sodium Ion

Autor: Shinobu Sato, Shigeori Takenaka, Yuuki Imaichi, Koji Nakazawa, Yukiko Yoshiura

Publikováno v: Analytical Sciences. 35(1):85-90

A peptide-oligonucleotide conjugate (1) was synthesized by the attachment of FAM, TAMRA, and biotin moieties to a telomere DNA sequence of 5'-TAG GGT TAG GGT TAG GGT TAG GG-3'. This conjugate was induced to be an anti-parallel structure in the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb94bf0275d12faeb07ae3b8cb3b627
https://kyutech.repo.nii.ac.jp/records/6085