Zobrazeno 1 - 10
of 2 079
pro vyhledávání: '"peptide synthetase"'
Autor:
Barbara R. Terlouw, Friederike Biermann, Sophie P. J. M. Vromans, Elham Zamani, Eric J. N. Helfrich, Marnix H. Medema
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Natural products are molecules that fulfil a range of important ecological functions. Many natural products have been exploited for pharmaceutical and agricultural applications. In contrast to many other specialised metabolites, the products
Externí odkaz:
https://doaj.org/article/05b9a26e73d14f05a536e4c5488a18c0
Publikováno v:
Shipin gongye ke-ji, Vol 45, Iss 17, Pp 445-453 (2024)
Secondary metabolites (SM) produced by filamentous fungi have been extensively applied in biomedicine, biological control, food, and other fields. The biosynthesis of most SMs is closely associated with the catalysis of non-ribosome peptide synthetas
Externí odkaz:
https://doaj.org/article/f642fb641ad1497ebd703698ae092dd1
Autor:
Lucía Graña-Miraglia, Jorge Luis Geney Higuita, Juan Carlos Salazar, Diana Guaya Iñiguez, Carlos Alcolado León, Víctor A. García-Angulo
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Pyoverdines are high affinity siderophores produced by most Pseudomonas with a wide role in microbial interspecies interactions. They are primarily composed of a conserved chromophore moiety, an acyl side chain and a peptide backbone which may be hig
Externí odkaz:
https://doaj.org/article/72697815a685425aa29367d4af57591c
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-22 (2024)
Abstract Fungal non-ribosomal peptide synthetase (NRPS)-encoding products play a paramount role in new drug discovery. Fusarium, one of the most common filamentous fungi, is well-known for its biosynthetic potential of NRPS-type compounds with divers
Externí odkaz:
https://doaj.org/article/255cb9baf07d4dd78fc4fb03488826bc
Autor:
Haixia Zang, Yijia Cheng, Mengjia Li, Lin Zhou, Li-Li Hong, Hai Deng, Hou-Wen Lin, Yongjun Zhou
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-11 (2024)
Abstract Background Natural tetramates are a family of hybrid polyketides bearing tetramic acid (pyrrolidine-2,4-dione) moiety exhibiting a broad range of bioactivities. Biosynthesis of tetramates in microorganisms is normally directed by hybrid poly
Externí odkaz:
https://doaj.org/article/3c8eb3ebe787474681008fcc9b16838c
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 321-330 (2024)
Several under-explored Aspergillus sp. produce intriguing heptapeptides containing a γ-aminobutyric acid (GABA) residue with as yet unknown biological functions. In this study, a new GABA-containing heptapeptide – unguisin J (1) – along with kno
Externí odkaz:
https://doaj.org/article/46568e21c00244a1b7a147d43b796093
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 445-451 (2024)
The adenylation (A) domain is essential for non-ribosomal peptide synthetases (NRPSs), which synthesize various peptide-based natural products, including virulence factors, such as siderophores and genotoxins. Hence, the inhibition of A-domains could
Externí odkaz:
https://doaj.org/article/fda6b33ee917401da302b4b9d9863f7f
Publikováno v:
Marine Drugs, Vol 22, Iss 8, p 349 (2024)
Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents. The
Externí odkaz:
https://doaj.org/article/0e500052f53c48028e4fa263110e0ec2
Publikováno v:
Insects, Vol 15, Iss 9, p 710 (2024)
Entomopathogenic bacteria, classified into the genus Xenorhabdus, exhibit a dual lifestyle as mutualistic symbionts to Steinernema nematodes and as pathogens to a broad range of insects. Bacterial virulence depends on toxin proteins that induce toxem
Externí odkaz:
https://doaj.org/article/97f3bd087c11411b82a6b21f60b75305
Autor:
Songya Zhang, Lin Zhang, Anja Greule, Julien Tailhades, Edward Marschall, Panward Prasongpholchai, Daniel J. Leng, Jingfan Zhang, Jing Zhu, Joe A. Kaczmarski, Ralf B. Schittenhelm, Oliver Einsle, Colin J. Jackson, Fabrizio Alberti, Andreas Bechthold, Youming Zhang, Manuela Tosin, Tong Si, Max J. Cryle
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 8, Pp 3561-3574 (2023)
WS9326A is a peptide antibiotic containing a highly unusual N-methyl-E-2-3-dehydrotyrosine (NMet-Dht) residue that is incorporated during peptide assembly on a non-ribosomal peptide synthetase (NRPS). The cytochrome P450 encoded by sas16 (P450Sas) ha
Externí odkaz:
https://doaj.org/article/7d63ec27ecab4b6da2493ecc0f966b70