Zobrazeno 1 - 10
of 6 975
pro vyhledávání: '"pbpk"'
Autor:
Monica Parkash, Muhammad Harris Shoaib, Muhammad Sikandar, Rabia Ismail Yousuf, Muhammad Talha Saleem, Farrukh Rafiq Ahmed, Fahad Siddiqui
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Metoclopramide is an antiemetic agent prescribed for motion sickness, cancer chemotherapy, and pregnancy. The present work aimed to design a metoclopramide-loaded halloysite nanotubes (HNTs) drug-in-adhesive transdermal drug delivery system.
Externí odkaz:
https://doaj.org/article/c42d8359715b45279fe5f2d43f324f5a
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 4585-4600 (2024)
Fengjiao Bu,1,2,* Yong-Soon Cho,3,4,* Qingfeng He,1 Xiaowen Wang,1 Saurav Howlader,3,4 Dong-Hyun Kim,3,4 Mingshe Zhu,5 Jae Gook Shin,3,4 Xiaoqiang Xiang1,6 1Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fuda
Externí odkaz:
https://doaj.org/article/64ebcf7edd7c469ca65f48c8471ef17b
Autor:
A. V. Suvorova, P. A. Losenkova, Yu. V. Medvedev, E. A. Malashenko, I. E. Makarenko, A. M. Poluyanov, I. E. Shohin
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 166-175 (2024)
Introduction. Deferasirox is a complexing drug and belongs to class II according to the biopharmaceutical classification system (BCS), has acidic properties and belongs to subclass “a” (acid). This class is characterized by high permeability and
Externí odkaz:
https://doaj.org/article/dbc1d4558e7042689e6d9613b3df9d1c
Autor:
A. V. Suvorova, Yu. V. Medvedev, P. A. Losenkova, O. S. Kramarenko, E. A. Malashenko, A. M. Poluyanov, I. E. Shohin
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 176-185 (2024)
Introduction. Sorafenib is an antineoplastic drug belonging to class IIc according to the biopharmaceutical classification system (BCS) due to the presence of both acidic and basic properties. In addition to low solubility, sorafenib is characterized
Externí odkaz:
https://doaj.org/article/f9432bbfce7f4c17baa107ecc3ecc108
Autor:
Yujie Yang, Yirong Wang, Wei Zeng, Jinhua Zhou, Min Xu, Ying Lan, Lvye Liu, Jian Shen, Chuan Zhang, Qin He
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract This study aimed to develop a physiologically based pharmacokinetic/pharmacodynamic model (PBPK/PD) of meropenem for critically ill patients. A PBPK model of meropenem in healthy adults was established using PK-Sim software and subsequently
Externí odkaz:
https://doaj.org/article/d85e00cfbc944feeabe5746ecd2e650f
Autor:
A. Najjar, D. Lange, C. Géniès, J. Kuehnl, A. Zifle, C. Jacques, E. Fabian, N. Hewitt, A. Schepky
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionAll cosmetic ingredients must be evaluated for their safety to consumers. In the absence of in vivo data, systemic concentrations of ingredients can be predicted using Physiologically based Pharmacokinetic (PBPK) models. However, more exa
Externí odkaz:
https://doaj.org/article/70a701f598ca4f37a81b11197d0df8b8
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionAnimal models play a vital role in pharmaceutical research and development by supporting the planning and design of later clinical studies. To improve confidence and reliability of first in human dose estimates it is essential to assess t
Externí odkaz:
https://doaj.org/article/584054ca9bd24dc6b481a8570bbae847
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The purpose of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model combined with an EGFR occupancy (EO) model for osimertinib (OSI) to predict plasma trough concentration (Ctrough) and the intracranial
Externí odkaz:
https://doaj.org/article/dd6d6c1b8ed445e99da2e1a610cf8e14
Publikováno v:
Future Pharmacology, Vol 4, Iss 2, Pp 317-335 (2024)
Pregnancy is associated with various physiological changes that can significantly impact the disposition of drugs. To further the insight into how pregnancy affects the pharmacokinetics of drugs at different stages, clinical studies can be simulated
Externí odkaz:
https://doaj.org/article/d7a4b6a7da2d454dbdbed7512c37f606
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