Dexmedetomidine inhibits the NF-κB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats

Autor: Fang Cheng, Feng-Feng Yan, Yue-Peng Liu, Yan Cong, Ke-Fu Sun, Xue-Ming He

Publikováno v: Pharmaceutical Biology, Vol 57, Iss 1, Pp 649-659 (2019)

Context: Dexmedetomidine (Dex) has been reported to have an anti-inflammatory effect. However, its role on osteoarthritis (OA) has not been explored. Objective: This study investigates the effect of Dex on OA rat model induced by papain. Materials an

Externí odkaz: https://doaj.org/article/ab64ca84b5ff4eb89df9617460e3d4c3

Neurotoxicity of intrathecal injections of dexmedetomidine into the rat spinal dorsal horn★

Autor: Hou, Jiabao, Xia, Zhongyuan, Xiao, Xingpeng, Wan, Xing, Zhao, Bo

Publikováno v: Neural Regeneration Research

To investigate the neurotoxicity of intrathecal injections of dexmedetomidine, Sprague-Dawley rats were intrathecally injected with dexmedetomidine at doses of 0.75, 1.50 and 3.00 μg/kg into the spinal dorsal horn. We found that c-Fos expression in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3097be2bef8a16f089beec3f480a2f8
http://europepmc.org/articles/PMC4302524

Spinal interleukin-33 and its receptor ST2 contribute to bone cancer-induced pain in mice.

Autor: Zhao J; Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Institute of Acupuncture Research, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China., Zhang H, Liu SB, Han P, Hu S, Li Q, Wang ZF, Mao-Ying QL, Chen HM, Jiang JW, Wu GC, Mi WL, Wang YQ

Publikováno v: Neuroscience [Neuroscience] 2013 Dec 03; Vol. 253, pp. 172-82. Date of Electronic Publication: 2013 Aug 26.