Zobrazeno 1 - 10
of 669
pro vyhledávání: '"paul de vos"'
Publikováno v:
Materials Today Bio, Vol 27, Iss , Pp 101129- (2024)
Pancreatic islet transplantation is proposed as a cure for type 1 diabetes mellitus (T1D). Despite its success in optimal regulation of glucose levels, limitations in longevity of islet grafts still require innovative solutions. Inflammatory stress p
Externí odkaz:
https://doaj.org/article/8bc3fe00b81a4c0b942b548533fc78af
Publikováno v:
Current Research in Food Science, Vol 9, Iss , Pp 100851- (2024)
The intestinal epithelium is an important gatekeeper of the human body by forming a barrier for the luminal content of the intestine. The barrier function is regulated by a complex crosstalk between different cell types, including cells from the ente
Externí odkaz:
https://doaj.org/article/50e8a3ec799c4d9aaa23a1586b683a27
Publikováno v:
Current Research in Food Science, Vol 8, Iss , Pp 100736- (2024)
In this study, an in vitro co-culture model using an electric cell-substrate impedance sensing system (ECIS) for testing the impact of real-time fermentation of non-digestible carbohydrates (NDCs) by the intestinal microbiota on gut barrier function
Externí odkaz:
https://doaj.org/article/5695a97f803c4aeca52f2a6f093e02a4
Autor:
Alexandra M. Smink, Bryan Ceballos, Taco Koster, Samuel Rodriquez, Michael Alexander, Jonathan R. T. Lakey, Paul de Vos
Publikováno v:
Macromol, Vol 2, Iss 3, Pp 476-484 (2022)
Subcutaneous polymer scaffolds have shown potential for creating an optimal transplantation site in cellular replacement therapy, e.g., when transplanting insulin-producing cells to cure type 1 diabetes. Imperative for these scaffolds is a high degre
Externí odkaz:
https://doaj.org/article/d3797e0f52ff46dc992c474107057367
Autor:
Sergio Enríquez-Flores, Luis A. Flores-López, Ignacio De la Mora-De la Mora, Itzhel García-Torres, Isabel Gracia-Mora, Pedro Gutiérrez-Castrellón, Cynthia Fernández-Lainez, Yoalli Martínez-Pérez, Alberto Olaya-Vargas, Paul de Vos, Gabriel López-Velázquez
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Human triosephosphate isomerase (HsTIM) is a central glycolytic enzyme and is overexpressed in cancer cells with accelerated glycolysis. Triple-negative breast cancer is highly dependent on glycolysis and is typically treated with a combinat
Externí odkaz:
https://doaj.org/article/8e40f3105af14974bb2c5361fb6ece02
Publikováno v:
Current Research in Structural Biology, Vol 6, Iss , Pp 100112- (2023)
Reducing inflammation by diet is a major goal for prevention or lowering symptoms of a variety of diseases, such as auto-immune reactions and cancers. Natural polysaccharides are increasingly gaining attention due to their potential immunomodulating
Externí odkaz:
https://doaj.org/article/c687431a42994a16960695aaee3ea55b
Autor:
Alexandra M. Smink, PhD, Samuel Rodriquez, BSc, Shiri Li, PhD, Bryan Ceballos, BSc, Nicole Corrales, BSc, Michael Alexander, MSc, Taco Koster, BSc, Bart J. de Haan, BSc, Jonathan R.T. Lakey, PhD, Paul de Vos, PhD
Publikováno v:
Transplantation Direct, Vol 9, Iss 1, p e1417 (2023)
Background. Islet transplantation is a promising treatment for type 1 diabetes. It has the potential to improve glycemic control, particularly in patients suffering from hypoglycemic unawareness and glycemic instability. As most islet grafts do not f
Externí odkaz:
https://doaj.org/article/7a12c68284c64b86bc847601e6c7bcf4
Approaches to discern if microbiome associations reflect causation in metabolic and immune disorders
Autor:
Marijana Basic, Dominique Dardevet, Peter Michael Abuja, Silvia Bolsega, Stéphanie Bornes, Robert Caesar, Francesco Maria Calabrese, Massimo Collino, Maria De Angelis, Philippe Gérard, Miguel Gueimonde, François Leulier, Eva Untersmayr, Evelien Van Rymenant, Paul De Vos, Isabelle Savary-Auzeloux
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Our understanding of microorganisms residing within our gut and their roles in the host metabolism and immunity advanced greatly over the past 20 years. Currently, microbiome studies are shifting from association and correlation studies to studies de
Externí odkaz:
https://doaj.org/article/8dace665075d45fcb8a597916270aa58
Autor:
Lucas de Freitas Pedrosa, Karen Rebouças Nascimento, Caroline Giacomelli Soares, Débora Preceliano de Oliveira, Paul de Vos, João Paulo Fabi
Publikováno v:
Plants, Vol 12, Iss 14, p 2750 (2023)
Pectin, a plant-derived polysaccharide, possesses immense technological and biological application value. Several variables influence pectin’s physicochemical aspects, resulting in different fermentations, interactions with receptors, and other fun
Externí odkaz:
https://doaj.org/article/078973ca2b524b89a492bc0417607d7d
Autor:
M. Rezaa Mohammadi, Samuel Mathew Rodriguez, Jennifer Cam Luong, Shiri Li, Rui Cao, Hamad Alshetaiwi, Hien Lau, Hayk Davtyan, Mathew Blurton Jones, Mahtab Jafari, Kai Kessenbrock, S. Armando Villalta, Paul de Vos, Weian Zhao, Jonathan R. T. Lakey
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Mohammadi et al. show that the transplantation of pancreatic islets within mesenchymal-stem cell (MSC) exosome-loaded hybrid alginate microcapsules in diabetic mice lead to diminished immune-based foreign body response and hyperglycemia control. This
Externí odkaz:
https://doaj.org/article/2679dce50030425f97c4feb28fe920b9