Zobrazeno 1 - 10
of 156
pro vyhledávání: '"patient-derived models"'
Autor:
Dennis S. Metselaar, Michaël H. Meel, Joshua R. Goulding, Aimeé du Chatinier, Leyla Rigamonti, Piotr Waranecki, Neal Geisemeyer, Mark C. de Gooijer, Marjolein Breur, Jan Koster, Sophie E.M. Veldhuijzen van Zanten, Marianna Bugiani, Niels E. Franke, Alyssa Reddy, Pieter Wesseling, Gertjan J.L. Kaspers, Esther Hulleman
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101700- (2024)
Summary: Atypical teratoid/rhabdoid tumors (ATRTs) are highly malignant embryonal tumors of the central nervous system with a dismal prognosis. Using a newly developed and validated patient-derived ATRT culture and xenograft model, alongside a panel
Externí odkaz:
https://doaj.org/article/dad8aa161f6e4aad834b1c8a6839ea6b
Autor:
Kun Xiang, Ergang Wang, John Mantyh, Gabrielle Rupprecht, Marcos Negrete, Golshid Sanati, Carolyn Hsu, Peggy Randon, Anders Dohlman, Kai Kretzschmar, Shree Bose, Nicholas Giroux, Shengli Ding, Lihua Wang, Jorge Prado Balcazar, Qiang Huang, Pasupathi Sundaramoorthy, Rui Xi, Shannon Jones McCall, Zhaohui Wang, Chongming Jiang, Yubin Kang, Scott Kopetz, Gregory E. Crawford, Steven M. Lipkin, Xiao‐Fan Wang, Hans Clevers, David Hsu, Xiling Shen
Publikováno v:
Advanced Science, Vol 11, Iss 16, Pp n/a-n/a (2024)
Abstract Patient‐Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient‐derived models of cancer (PDMC). Nevertheless, how patient tumor cells evolve in these models and the impact on drug response remains unclear
Externí odkaz:
https://doaj.org/article/1bb7ddf32e6044c991fd4618eff54a98
Autor:
Verónica Rey, Juan Tornín, Juan Jose Alba-Linares, Cristina Robledo, Dzohara Murillo, Aida Rodríguez, Borja Gallego, Carmen Huergo, Cristina Viera, Alejandro Braña, Aurora Astudillo, Dominique Heymann, Karoly Szuhai, Judith V.M.G. Bovée, Agustín F. Fernández, Mario F. Fraga, Javier Alonso, René Rodríguez
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105090- (2024)
Summary: Background: Sarcomas represent an extensive group of malignant diseases affecting mesodermal tissues. Among sarcomas, the clinical management of chondrosarcomas remains a complex challenge, as high-grade tumours do not respond to current the
Externí odkaz:
https://doaj.org/article/a9bcedfaab4940eeb62fdf6d5e65245e
Autor:
Joan Seoane
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1169-1172 (2023)
Cancer immunotherapy has revolutionized the treatment of some malignancies. Yet, many tumors do not unfortunately respond to immune‐based therapies. Deeper insights into the biology of the immune response to cancer are required to identify novel th
Externí odkaz:
https://doaj.org/article/db90f1a338064ac49408aa03a29510b7
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/b6e9763327414aa79afd9571b92ca5cd
Autor:
Divya L. Dayanidhi, Jason A. Somarelli, John B. Mantyh, Gabrielle Rupprecht, Roham Salman Roghani, Sophia Vincoff, Iljin Shin, Yiquan Zhao, So Young Kim, Shannon McCall, Jiyong Hong, David S. Hsu
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/3ce819b3570744e6b93e60cc70e9e3ea
Autor:
Kaiwen Chen, Yanran Li, Bingran Wang, Xuehan Yan, Yiying Tao, Weizhou Song, Zhifeng Xi, Kang He, Qiang Xia
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Liver cancer is an aggressive tumor originating in the liver with a dismal prognosis. Current evidence suggests that liver cancer is the fifth most prevalent cancer worldwide and the second most deadly type of malignancy. Tumor heterogeneity accounts
Externí odkaz:
https://doaj.org/article/4c6a22149bfd44eebcd5edb97368191d
Autor:
Kristina Aaltonen, Katarzyna Radke, Aleksandra Adamska, Alexandra Seger, Adriana Mañas, Daniel Bexell
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. High-risk neuroblastoma patients have a poor overall survival and account for ~15% of childhood cancer deaths. There is thus a need for clinically relevant and authentic
Externí odkaz:
https://doaj.org/article/a84a512f5e3641ab9c57460d1a2c0b39
Autor:
Divya L. Dayanidhi, Jason A. Somarelli, John B. Mantyh, Gabrielle Rupprecht, Roham Salman Roghani, Sophia Vincoff, Iljin Shin, Yiquan Zhao, So Young Kim, Shannon McCall, Jiyong Hong, David S. Hsu
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Colorectal cancer (CRC) is the third most prevalent form of cancer in the United States and results in over 50,000 deaths per year. Treatments for metastatic CRC are limited, and therefore there is an unmet clinical need for more effective therapies.
Externí odkaz:
https://doaj.org/article/a7ae9050338a4bf4b109f13416c91426
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