Zobrazeno 1 - 10
of 1 811
pro vyhledávání: '"patient stratification"'
Autor:
Manuel A. González Hernández, Lars Verschuren, Martien P.M. Caspers, Martine C. Morrison, Jennifer Venhorst, Jelle T. van den Berg, Beatrice Coornaert, Roeland Hanemaaijer, Gerard J. P. van Westen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide. Drug therapy is hampered by large patient variability and partial representation of human MASH fibrosis in preclinical models. Here, we investigated the mec
Externí odkaz:
https://doaj.org/article/655a3f5a3c6143cd8f62fdeaec52efc2
Autor:
Katrine Baumann, Jennifer Astrup Sørensen, Ditte G. Zhang, Misbah N. Ghazanfar, Per Stahl Skov, Anders Woetmann, Simon Francis Thomsen
Publikováno v:
JEADV Clinical Practice, Vol 3, Iss 2, Pp 658-663 (2024)
Abstract Background Patients suffering from chronic spontaneous urticaria (CSU) are typically classified as type I or type IIb autoimmune CSU, but further patient stratification is hindered by the lack of biomarkers. Objectives We investigated whethe
Externí odkaz:
https://doaj.org/article/0b6d62e297af4412911e7ae82b6fadb7
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
Asthma has become one of the most serious chronic respiratory diseases threatening people's lives worldwide. The pathogenesis of asthma is complex and driven by numerous cells and their interactions, which contribute to its genetic and phenotypic het
Externí odkaz:
https://doaj.org/article/00f1c63142454e259bc3891c97b6d0b4
Autor:
Simon M. Frey, Gabrielle Huré, Jan-Philipp Leibfarth, Kathrin Thommen, Melissa Amrein, Klara Rumora, Ibrahim Schäfer, Federico Caobelli, Damian Wild, Philip Haaf, Christian E. Mueller, Michael J. Zellweger
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundDespite clinical suspicion, most non-invasive ischemia tests for coronary artery disease (CAD) reveal unremarkable results. Patients with a coronary artery calcium score (CACS) of zero rarely have an abnormal positron emission tomography (P
Externí odkaz:
https://doaj.org/article/98d7185203d041a786ee389c97ca7a81
Autor:
Shen Zhao, Chao-Yang Yan, Hong Lv, Jing-Cheng Yang, Chao You, Zi-Ang Li, Ding Ma, Yi Xiao, Jia Hu, Wen-Tao Yang, Yi-Zhou Jiang, Jun Xu, Zhi-Ming Shao
Publikováno v:
Fundamental Research, Vol 4, Iss 3, Pp 678-689 (2024)
Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype. Molecular stratification and target therapy bring clinical benefit for TNBC patients, but it is difficult to implement comprehensive molecular testing in clinical pra
Externí odkaz:
https://doaj.org/article/621e0e6df23c4af781af26d51367e444
Autor:
Ellen D. Kaan, Tammo E. Brunekreef, Julia Drylewicz, Lucas L. van den Hoogen, Maarten van der Linden, Helen L. Leavis, Jacob M. van Laar, Michiel van der Vlist, Henny G. Otten, Maarten Limper
Publikováno v:
Journal of Translational Autoimmunity, Vol 9, Iss , Pp 100246- (2024)
Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a variety of disease symptoms and an unpredictable clinical course. To improve treatment outcome, stratification based on immunological manifestations commonly se
Externí odkaz:
https://doaj.org/article/04b3c7987a8e4c35b53ca455a1fda635
Autor:
Abudukeyoumu Maimaitiyiming, Hengqing An, Chen Xing, Xiaodong Li, Zhao Li, Junbo Bai, Cheng Luo, Tao Zhuo, Xin Huang, Aierpati Maimaiti, Abudushalamu Aikemu, Yujie Wang
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35157- (2024)
Background: The role of Mast cells has not been thoroughly explored in the context of prostate cancer's (PCA) unpredictable prognosis and mixed immunotherapy outcomes. Our research aims to employs a comprehensive computational methodology to evaluate
Externí odkaz:
https://doaj.org/article/1145c2ca6bd648429a5c7b352aa4e868
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 2, Pp 100458- (2024)
Objective: Developing new therapies for knee osteoarthritis (KOA) requires improved prediction of disease progression. This study evaluated the prognostic value of clinical clusters and machine-learning derived quantitative 3D bone shape B-score for
Externí odkaz:
https://doaj.org/article/17994b58de7b498d90549e144b8f1039
Autor:
Heather Marriott, Renata Kabiljo, Guy P Hunt, Ahmad Al Khleifat, Ashley Jones, Claire Troakes, Project MinE ALS Sequencing Consortium, TargetALS Sequencing Consortium, Abigail L Pfaff, John P Quinn, Sulev Koks, Richard J Dobson, Patrick Schwab, Ammar Al-Chalabi, Alfredo Iacoangeli
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) displays considerable clinical and genetic heterogeneity. Machine learning approaches have previously been utilised for patient stratification in ALS as they can disentangle complex disease landscapes. How
Externí odkaz:
https://doaj.org/article/0039ccac3a864796aca41190b1b2c47d
Autor:
Clinton JW, Cross RK
Publikováno v:
Clinical and Experimental Gastroenterology, Vol Volume 16, Pp 249-276 (2023)
Joseph William Clinton, Raymond Keith Cross Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD, USACorrespondence: Joseph William Clinton, Department of Medicine, Division of
Externí odkaz:
https://doaj.org/article/6d09deb7b93342bd9471c13e7ae41623