Zobrazeno 1 - 10
of 890
pro vyhledávání: '"patient derived organoids"'
Autor:
Lingwei Wang, Yanli Yu, Yanhua Fang, Yanjiao Li, Weiting Yu, Zhe Wang, Jinyan Lv, Ruoyu Wang, Shanshan Liang
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-5 (2024)
Abstract The Patient-Derived Organoids (PDOs) has demonstrated significant potential in personalized medicine. However, the initial establishment of lung cancer organoids (LCOs), and timely therapeutic recommendations face several challenges. Particu
Externí odkaz:
https://doaj.org/article/9b21d1d078944bc1b8c519a4df21d1cf
Autor:
Michael Karl Melzer, Yanchun Ma, Jessica Lindenmayer, Clara Morgenstern, Felix Wezel, Friedemann Zengerling, Cagatay Günes, Nadine Therese Gaisa, Alexander Kleger, Christian Bolenz
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-7 (2024)
Abstract Urothelial carcinoma (UC) of the urinary bladder has significant challenges in treatment due to its diverse genetic landscape and variable response to systemic therapy. In recent years, patient-derived organoids (PDOs) emerged as a novel too
Externí odkaz:
https://doaj.org/article/cfc496e6e02e4966b81c02bc4a642b0d
Autor:
Elham Aida Farshadi, Wenya Wang, Farzana Mohammad, Elise van der Oost, Michail Doukas, Casper H. J. van Eijck, Harmen J. G. van de Werken, Peter D. Katsikis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) presents challenges in detecting somatic mutations due to its complex cellular composition. This study investigated the utility of patient-derived organoids (PDOs) to overcome these obstacles and enhan
Externí odkaz:
https://doaj.org/article/77ac9a8ef4ef4a1b84739b3ddce172bb
Autor:
Lin-Yu Chen, Yu-Ting Chou, Phui-Ly Liew, Ling-Hui Chu, Kuo-Chang Wen, Shiou-Fu Lin, Yu-Chun Weng, Hui-Chen Wang, Po-Hsuan Su, Hung-Cheng Lai
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-12 (2024)
Abstract Background Ovarian cancer is the most lethal gynecological cancer. As the primary treatment, chemotherapy has a response rate of only 60–70% in advanced stages, and even lower as a second-line treatment. Despite guideline recommendations,
Externí odkaz:
https://doaj.org/article/ad9976421da742c6a2aa45c571630064
Autor:
Katarína Benčurová, Loan Tran, Joachim Friske, Kajetana Bevc, Thomas H. Helbich, Marcus Hacker, Michael Bergmann, Markus Zeitlinger, Alexander Haug, Markus Mitterhauser, Gerda Egger, Theresa Balber
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Background Patient-derived tumour organoids (PDOs) are highly advanced in vitro models for disease modelling, yet they lack vascularisation. To overcome this shortcoming, organoids can be inoculated onto the chorioallantoic membrane (CAM); t
Externí odkaz:
https://doaj.org/article/48f2547814c0420393b98e3489f9e77f
Autor:
Jakub Gubala, Valentin Mieville, Daniel Benamran, Jean-Christophe Tille, Massimo Valerio, Patrycja Nowak-Sliwinska
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101368- (2024)
Despite significant advancements in targeted- and immunotherapies, millions of patients with cancer still succumb to the disease each year. In renal cell carcinoma, up to 25% of metastatic patients do not respond to first-line therapies. This reality
Externí odkaz:
https://doaj.org/article/81ec4dbae967461686ba56f0858edb33
Autor:
Sandra Cordeiro, Beatriz B. Oliveira, Ruben Valente, Daniela Ferreira, André Luz, Pedro V. Baptista, Alexandra R. Fernandes
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Despite extensive efforts to unravel tumor behavior and develop anticancer therapies, most treatments fail when advanced to clinical trials. The main challenge in cancer research has been the absence of predictive cancer models, accurately mimicking
Externí odkaz:
https://doaj.org/article/40cce755c8cb40f2959b883a26c7eef9
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Esophageal adenocarcinoma (EAC) is a subtype of esophageal cancer with significant morbidity and mortality rates worldwide. Despite advancements in tumor models, the underlying cellular and molecular mechanisms driving EAC pathogenesis are still poor
Externí odkaz:
https://doaj.org/article/a059470f60e1423ca5252b807823d690
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Tumor organoids, an in-vitro three-dimensional model, possess high potential for investigating tumor biology and treatment response and have been demonstrated more appropriate for drug assessment than two-dimensional cultures. Herein, we described tw
Externí odkaz:
https://doaj.org/article/3fe2db0a8dfd4ac995c28d43d7f665f4
Autor:
XiaoChang Fang, Lin Shu, TianLiang Chen, XiaoLe Zhao, LiuCui Yang, Tingting Dou, Lijie Yang, Xuanfei Li, Maohui Feng
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract Background Malignant peritoneal mesothelioma (MPM) is an extremely rare and highly invasive tumor. Due to the lack of accurate models that reflect the biological characteristics of primary tumors, studying MPM remains challenging and is asso
Externí odkaz:
https://doaj.org/article/021181a682df48deb1583ed04cb35775