Zobrazeno 1 - 10
of 8 551
pro vyhledávání: '"patient‐derived"'
Autor:
Lingwei Wang, Yanli Yu, Yanhua Fang, Yanjiao Li, Weiting Yu, Zhe Wang, Jinyan Lv, Ruoyu Wang, Shanshan Liang
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-5 (2024)
Abstract The Patient-Derived Organoids (PDOs) has demonstrated significant potential in personalized medicine. However, the initial establishment of lung cancer organoids (LCOs), and timely therapeutic recommendations face several challenges. Particu
Externí odkaz:
https://doaj.org/article/9b21d1d078944bc1b8c519a4df21d1cf
Autor:
Michael Karl Melzer, Yanchun Ma, Jessica Lindenmayer, Clara Morgenstern, Felix Wezel, Friedemann Zengerling, Cagatay Günes, Nadine Therese Gaisa, Alexander Kleger, Christian Bolenz
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-7 (2024)
Abstract Urothelial carcinoma (UC) of the urinary bladder has significant challenges in treatment due to its diverse genetic landscape and variable response to systemic therapy. In recent years, patient-derived organoids (PDOs) emerged as a novel too
Externí odkaz:
https://doaj.org/article/cfc496e6e02e4966b81c02bc4a642b0d
Autor:
Xiaoqing Wang, Ju Zhu, Lingling Li, Qilin Zhao, Yutang Huang, Chunjie Wen, Dan Chen, Lanxiang Wu
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-16 (2024)
Abstract Background Patient-derived xenograft (PDX) is currently considered a preferred preclinical model to evaluate drug sensitivity, explore drug resistance mechanisms, and select individualized treatment regimens. Methods Histopathological examin
Externí odkaz:
https://doaj.org/article/0d7cbfbfabc24a318b9e68dfc9b72d47
Autor:
Xiu-Ya Chan, Kai-Ping Chang, Chia-Yu Yang, Chiao-Rou Liu, Chu-Mi Hung, Chun-Chueh Huang, Hao-Ping Liu, Chih-Ching Wu
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-25 (2024)
Abstract Background Oral cancer accounts for 2% of cancer-related deaths globally, with over 90% of cases being oral cavity squamous cell carcinomas (OSCCs). Approximately 50% of patients with OSCC succumb to the disease within 5 years, primarily due
Externí odkaz:
https://doaj.org/article/386a2840509f4202adb4b09360e0f660
Autor:
Elham Aida Farshadi, Wenya Wang, Farzana Mohammad, Elise van der Oost, Michail Doukas, Casper H. J. van Eijck, Harmen J. G. van de Werken, Peter D. Katsikis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) presents challenges in detecting somatic mutations due to its complex cellular composition. This study investigated the utility of patient-derived organoids (PDOs) to overcome these obstacles and enhan
Externí odkaz:
https://doaj.org/article/77ac9a8ef4ef4a1b84739b3ddce172bb
Autor:
Lin-Yu Chen, Yu-Ting Chou, Phui-Ly Liew, Ling-Hui Chu, Kuo-Chang Wen, Shiou-Fu Lin, Yu-Chun Weng, Hui-Chen Wang, Po-Hsuan Su, Hung-Cheng Lai
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-12 (2024)
Abstract Background Ovarian cancer is the most lethal gynecological cancer. As the primary treatment, chemotherapy has a response rate of only 60–70% in advanced stages, and even lower as a second-line treatment. Despite guideline recommendations,
Externí odkaz:
https://doaj.org/article/ad9976421da742c6a2aa45c571630064
Autor:
Daniela Šimčíková, Dominik Gardáš, Tomáš Pelikán, Lukáš Moráň, Martin Hruda, Kateřina Hložková, Tiziana Pivetta, Michal Hendrych, Júlia Starková, Lukáš Rob, Petr Vaňhara, Petr Heneberg
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-19 (2024)
Abstract Background High-grade serous ovarian carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian carcinoma. It is primarily diagnosed at stage III or IV when the 5-year survival rate ranges between 20% and 40%. Here, we
Externí odkaz:
https://doaj.org/article/7312a3cb95514293b2aa5a156c7818c7
Autor:
Lilian Roth, Linda Huynh-Russo, Laura Heeb, Sima Ulugöl, Rafael Freire Dos Santos, Eva Breuer, Udo Ungethüm, Martina Haberecker, Chantal Pauli, Viktor Koelzer, Kuno Lehmann, Anurag Gupta
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Multimodal therapy for peritoneal metastasis (PM) including cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provides long-term survival in highly selected colorectal cancer patients. Mechanisms behind HIPEC
Externí odkaz:
https://doaj.org/article/fad11af395664b6181c3d0cec33526fd
Autor:
Katarína Benčurová, Loan Tran, Joachim Friske, Kajetana Bevc, Thomas H. Helbich, Marcus Hacker, Michael Bergmann, Markus Zeitlinger, Alexander Haug, Markus Mitterhauser, Gerda Egger, Theresa Balber
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Background Patient-derived tumour organoids (PDOs) are highly advanced in vitro models for disease modelling, yet they lack vascularisation. To overcome this shortcoming, organoids can be inoculated onto the chorioallantoic membrane (CAM); t
Externí odkaz:
https://doaj.org/article/48f2547814c0420393b98e3489f9e77f
Publikováno v:
口腔疾病防治, Vol 32, Iss 9, Pp 653-663 (2024)
Exploration of the underlying mechanisms of tumor occurrence and development, as well as evaluation of the efficacy of anticancer drug treatments, relies on various research models both in vivo and in vitro. Over the past few decades, with the rapid
Externí odkaz:
https://doaj.org/article/be2ed146fff3431e84f189803a09880e