Zobrazeno 1 - 10
of 20
pro vyhledávání: '"pathway of effects"'
Publikováno v:
Royal Society Open Science, Vol 11, Iss 4 (2024)
This review comprehensively evaluates the impacts of anthropogenic threats on beaked whales (Ziphiidae)—a taxonomic group characterized by cryptic biology, deep dives and remote offshore habitat, which have challenged direct scientific observation.
Externí odkaz:
https://doaj.org/article/95c45220e35e4a98bf1ace3d93264970
Akademický článek
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Akademický článek
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Autor:
Chanyi Lu, Xiaoli Lin, Jumpei Yamashita, Ranhui Xi, Minliang Zhou, Yali V. Zhang, Hong Wang, Robert F. Margolskee, Bon-Kyoung Koo, Hans Clevers, Ichiro Matsumoto, Peihua Jiang
Publikováno v:
Stem Cell Reports, 17(2), 369-383. Cell Press
Taste bud cells are renewed throughout life in a process requiring innervation. Recently, we reported that R-spondin substitutes for neuronal input for taste cell regeneration. R-spondin amplifies WNT signaling by interacting with stem-cell-expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fbbb32fc7ce9e25325c3bf90b0952a
https://pubmed.ncbi.nlm.nih.gov/34995498
https://pubmed.ncbi.nlm.nih.gov/34995498
Autor:
Cezanne Miete, Gonzalo P. Solis, Alexey Koval, Martina Brückner, Vladimir L. Katanaev, Jürgen Behrens, Dominic B. Bernkopf
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Nature communications, Vol. 13, No 1 (2022) P. 674
Nature communications, Vol. 13, No 1 (2022) P. 674
Conductin/axin2 is a scaffold protein negatively regulating the pro-proliferative Wnt/β-catenin signaling pathway. Accumulation of scaffold proteins in condensates frequently increases their activity, but whether condensation contributes to Wnt path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe885a2c8672e90aca452bf1e54608d6
https://pubmed.ncbi.nlm.nih.gov/35115535
https://pubmed.ncbi.nlm.nih.gov/35115535
Autor:
Kang Yell Choi, Jong Chan Park, Jeong Su Yoon, Yong Hee Cho, Dong Woo Kang, Eun Ji Ro, Hans Clevers, Tae Il Kim, Tomohiro Mizutani
Publikováno v:
Nature Communications, 11(1). Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
5-Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective clinical outcomes for CRC patients. Here, we demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c3cd05c8716e3e7fd22f0717726d0f
https://hdl.handle.net/20.500.11755/de483e27-9a68-49de-bf37-80bb92ac9c00
https://hdl.handle.net/20.500.11755/de483e27-9a68-49de-bf37-80bb92ac9c00
Autor:
Jean-Luc Wolfender, Constant Anatole Pieme, Vladimir L. Katanaev, Tatiana V. Petrova, Artem Blagodatski, Emerson Ferreira Queiroz, Kamal Ahmed, Alexey Koval, Simone Ragusa
Publikováno v:
Cancer Letters, Vol. 435 (2018) pp. 110-120
Triple-negative breast cancer (TNBC) and colon cancer (CC) are two stigmatic examples of poorly treatable tumors, whose progression critically depends upon hyperactivation of the Wnt signaling. Development of specific anti-Wnt inhibitors is required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ea4ca74943aba182086d35f7e52d09
https://doi.org/10.1016/j.canlet.2018.08.003
https://doi.org/10.1016/j.canlet.2018.08.003
Publikováno v:
Pharmacological Reviews. 70(1):68-141
WNT signaling is an elaborate and complex collection of signal transduction pathways mediated by multiple signalingmolecules. WNT signaling is critically important for developmental processes, including cell proliferation, differentiation and tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od________83::8b81ed39805ccb1acd8a12e943c7c782
https://doi.org/10.1124/pr.117.013896
https://doi.org/10.1124/pr.117.013896
Autor:
Evangelos P. Daskalopoulos, W. Matthijs Blankesteijn, Gentian Lluri, Kevin C.M. Hermans, Arjun Deb, Sébastien Foulquier
Publikováno v:
Pharmacological reviews, Vol. 70, no.1, p. 68-141 (2018)
Pharmacological Reviews
Pharmacological Reviews
WNT signaling is an elaborate and complex collection of signal transduction pathways mediated by multiple signalingmolecules. WNT signaling is critically important for developmental processes, including cell proliferation, differentiation and tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4bdf25d7c7cd5abbf4c0d440fa470f
https://doi.org/10.1124/pr.117.013896
https://doi.org/10.1124/pr.117.013896
Publikováno v:
Cancer Letters, Vol. 449 (2019) pp. 45-55
Cancer letters, vol. 449, pp. 45-55
Cancer letters, vol. 449, pp. 45-55
Wnt signaling is overactivated in triple-negative breast cancer (TNBC) and several other cancers, and its suppression emerges as an effective anticancer treatment. However, no drugs targeting the Wnt pathway exist on the market nor in advanced clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7719a415a4510aa37abd138c2ccc790
https://archive-ouverte.unige.ch/unige:115677
https://archive-ouverte.unige.ch/unige:115677
