Výsledky vyhledávání - "pathology [Neurodegenerative Diseases]"

Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice

Autor: Laura Malz, Eva M Szego, Nadine Bernhardt, Angela Rösen-Wolff, Björn H Falkenburger, Hella Luksch

Publikováno v: eLife 11, e81943 (2022). doi:10.7554/eLife.81943

Stimulator of interferon genes (STING) is activated after detection of cytoplasmic dsDNA by cGAS (cyclic GMP-AMP synthase) as part of the innate immunity defence against viral pathogens. STING binds TANK-binding kinase 1 (TBK1). TBK1 mutations are as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ebd0eda879f38af5d4f9039f24f7b0
https://pubmed.ncbi.nlm.nih.gov/36314770

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Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns

Publikováno v: Journal of Neuropathology and Experimental Neurology
Journal of neuropathology and experimental neurology 79(11), 1141-1146 (2020). doi:10.1093/jnen/nlaa109

Recent studies in animal models demonstrate that certain misfolded proteins associated with neurodegenerative diseases can support templated misfolding of cognate native proteins, to propagate across neural systems, and to therefore have some of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b04ff8d370b02ea54af1da56b42d2b7
http://europepmc.org/articles/PMC7577514

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Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid‐binding protein 3 and ferritin to neurodegeneration and neuroinflammation

Autor: Frank Jessen, Carl-Christian Kolbe, Sergio Castro-Gomez, Pawel Tacik, Kilian Kleemann, Eicke Latz, Francesco Santarelli, Frederic Brosseron, Michael T. Heneka

Publikováno v: Journal of neurochemistry 157(6), 2210-2224 (2021). doi:10.1111/jnc.15175

There is growing evidence that promising biomarkers of inflammation in Alzheimer´s disease (AD) and other neurodegenerative diseases correlate strongest to levels of tau or neurofilament, indicating an inflammatory response to neuronal damage or dea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1669f6412a8a900d4d3fcf5b53bb82dc
https://doi.org/10.1111/jnc.15175

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Biomolecular condensation of the microtubule-associated protein tau

Autor: Tina Ukmar-Godec, Susanne Wegmann, Markus Zweckstetter

Publikováno v: Seminars in cell & developmental biology 99, 202-214 (2020). doi:10.1016/j.semcdb.2019.06.007
Seminars in Cell & Developmental Biology
Seminars in Cell and Developmental Biology

Cells contain multiple compartments dedicated to the regulation and control of biochemical reactions. Cellular compartments that are not surrounded by membranes can rapidly form and dissolve in response to changes in the cellular environment. The phy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad359f1a898f274de7502e4eb297c58
https://doi.org/10.1016/j.semcdb.2019.06.007

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Lifetime risk of autosomal recessive neurodegeneration with brain iron accumulation (NBIA) disorders calculated from genetic databases

Autor: Hana Kolarova, Jing Tan, Tim M. Strom, Thomas Meitinger, Matias Wagner, Thomas Klopstock

Publikováno v: EBioMedicine 77, 103869 (2022). doi:10.1016/j.ebiom.2022.103869
EBioMedicine 77:103869 (2022)
EBioMedicine, Vol 77, Iss, Pp 103869-(2022)

Neurodegeneration with brain iron accumulation (NBIA) are a group of clinically and genetically heterogeneous diseases characterized by iron overload in basal ganglia and progressive neurodegeneration. Little is known about the epidemiology of NBIA d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c582c79e062a09eafa866e0479ccdb
https://pub.dzne.de/record/163460

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In vivoimaging reveals reduced activity of neuronal circuits in a mouse tauopathy model

Autor: Petar Marinković, Jochen Herms, Pieter M. Goltstein, Finn Peters, Sonja Blumenstock, Andreas Knebl, Viktoria Korzhova

Publikováno v: Brain 142(4), 1051-1062 (2019). doi:10.1093/brain/awz035
Brain

Pathological alterations of tau protein play a significant role in the emergence and progression of neurodegenerative disorders. Tauopathies are characterized by detachment of the tau protein from neuronal microtubules, and its subsequent aberrant hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55aa647998adfcfa6cf27f4bfb427c9a
https://doi.org/10.1093/brain/awz035

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Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

Autor: Peter C. Reinacher, Josef Priller, Ralf Gold, Anna Michel, Geert van Loo, Ulrich Sure, Marco Prinz, Roman Sankowski, Christine Stadelmann, Sagar, Dominic Grün, Takahiro Masuda, Stefan Nessler, Ori Staszewski, Volker A. Coenen, Christian Scheiwe, Patrik Kunz, Lukas Amann, Chotima Böttcher

Publikováno v: Masuda, T, Sankowski, R, Staszewski, O, Böttcher, C, Amann, L, Scheiwe, C, Nessler, S, Kunz, P, van Loo, G, Arnd Coenen, V, Reinacher, P C, Michel, A, Sure, U, Gold, R, Grün, D, Priller, J, Stadelmann, C & Prinz, M 2019, ' Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution ', Nature, vol. 566, no. 7744, pp. 388-392 . https://doi.org/10.1038/s41586-019-0924-x
Nature 566(7744), 388-392 (2019). doi:10.1038/s41586-019-0924-x
Nature

Microglia have critical roles not only in neural development and homeostasis, but also in neurodegenerative and neuroinflammatory diseases of the central nervous system1-4. These highly diverse and specialized functions may be executed by subsets of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368ad77538dcab2f43f3ea8b59015268
https://doi.org/10.1038/s41586-019-0924-x

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TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau

Autor: Muhammet M Öztürk, Bryce L Mashimo, Maria Medalla, Lulu Jiang, Samantha Boudeau, Peter E.A. Ash, Guillermo Socorro, Jenifer Shattuck, Susanne Wegmann, Pavel Ivanov, Yari Carlomagno, Nicholas M. Kanaan, Benjamin Wolozin, Mark Knobel, Leonard Petrucelli, Shuwen Lei, Louloua F A Al-Mohanna

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(9), e2014188118-(2021). doi:10.1073/pnas.2014188118

Significance Phase separation of proteins is increasingly thought to play a fundamental role in biological processes. Recent studies show that tau protein phase separates, but the biological significance is unknown since artificial crowding agents ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d0a132fc70ab180f1313204a691274
http://europepmc.org/articles/PMC7936275

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NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression

Autor: David Mengel, Tze How Mok, Akin Nihat, Wen Liu, Robert A. Rissman, Douglas Galasko, Henrik Zetterberg, Simon Mead, John Collinge, Dominic M. Walsh

Publikováno v: Cells 10(12), 3514 (2021). doi:10.3390/cells10123514 special issue: "Biomarkers of Alzheimer’s Disease: New Insights"
Cells
Cells; Volume 10; Issue 12; Pages: 3514
Cells, Vol 10, Iss 3514, p 3514 (2021)

This study investigates the diagnostic and prognostic potential of different forms of tau in biofluids from patients with Creutzfeldt-Jakob disease (CJD). Extracellular tau, which is molecularly heterogeneous, was measured using ultra-sensitive custo

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https://pub.dzne.de/record/163418

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