Zobrazeno 1 - 8
of 8
pro vyhledávání: '"pathology [Neuroblastoma]"'
Autor:
Karina Häbig, Thomas Hentrich, Birgit Heim, Florian Giesert, Carolin Walter, Olaf Riess, Michael Bonin, Wolfgang Wurst, Sandra Gellhaar, Verena Djuric
Publikováno v:
Biochimica et biophysica acta / Molecular basis of disease 1832(12), 2352-2367 (2013). doi:10.1016/j.bbadis.2013.09.009
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common genetic cause of Parkinson's disease (PD). However, LRRK2 function and molecular mechanisms causing the parkinsonian phenotype remain widely unknown. Most of LRRK2 k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ba353f29c2943ab3f209bd31a5e546
https://doi.org/10.1016/j.bbadis.2013.09.009
https://doi.org/10.1016/j.bbadis.2013.09.009
Autor:
Nesli-Ece Sen, Sylvia Torres-Odio, Halil Güllüoğlu, Gülden Akdal, Ewa Damrath, Suzana Gispert, Jessica Drost, A. Nazli Basak, Hamid Hamzeiy, Michael Klinkenberg, Georg Auburger
Publikováno v:
Neurobiology of disease 96, 115-126 (2016). doi:10.1016/j.nbd.2016.09.002
Neurobiology of Disease, Vol 96, Iss, Pp 115-126 (2016)
Neurobiology of Disease, Vol 96, Iss, Pp 115-126 (2016)
Ataxin-2 (ATXN2) polyglutamine domain expansions of large size result in an autosomal dominantly inherited multi-system-atrophy of the nervous system named spinocerebellar ataxia type 2 (SCA2), while expansions of intermediate size act as polygenic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27d977f7a0e8065fda7c7f94e6fb1cd
https://avesis.deu.edu.tr/publication/details/e57de45d-a606-45d0-a522-1d0cb2b84c01/oai
https://avesis.deu.edu.tr/publication/details/e57de45d-a606-45d0-a522-1d0cb2b84c01/oai
Autor:
Markus Zweckstetter, Nasrollah Rezaei-Ghaleh, Patrick Wunderlich, Dietmar Rudolf Thal, Jochen Walter, Thomas A. Bayer, Sathish Kumar, Kathrin Stüber, Sandra Theil, Philipp Koch, Oliver Brüstle, Oliver Wirths
Publikováno v:
Acta Neuropathologica
Acta neuropathologica 131(4), 525-537 (2016). doi:10.1007/s00401-016-1546-0
Acta neuropathologica 131(4), 525-537 (2016). doi:10.1007/s00401-016-1546-0
Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer’s disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0728842bd419776cad0530d485f5eb0
https://lirias.kuleuven.be/handle/123456789/545197
https://lirias.kuleuven.be/handle/123456789/545197
Autor:
Brandley T. Hyman, Laiq-Jan Saidi, Tara L. Spires-Jones, Eva-Maria Mandelkow, Manuela Polydoro, Kevin R Kay, Laura Sanchez
Publikováno v:
Journal of Alzheimer's Disease
Journal of Alzheimer's disease 44(3), 937-947 (2015). doi:10.3233/JAD-142094
Journal of Alzheimer's disease 44(3), 937-947 (2015). doi:10.3233/JAD-142094
One of the hallmarks of Alzheimer's disease is the formation of neurofibrillary tangles, intracellular aggregates of hyperphosphorylated, mislocalized tau protein, which are associated with neuronal loss. Changes in tau are known to impair cellular t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d06a6bec55b4ee6ec3914b04abd5809
https://hdl.handle.net/11858/00-001M-0000-0029-70CA-011858/00-001M-0000-0029-70CC-C
https://hdl.handle.net/11858/00-001M-0000-0029-70CA-011858/00-001M-0000-0029-70CC-C
Autor:
Uwe Horn, Damian C. Crowther, Marcus Fändrich, Raik Rönicke, Christopher M. Dobson, Leila M. Luheshi, Klaus G. Reymann, Melanie Wulff, Martin Westermann, Jessica Wacker
Publikováno v:
Acta Neuropathologica Communications 2(1), 43 (2014). doi:10.1186/2051-5960-2-43
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Introduction The self-assembly of Aβ peptides into a range of conformationally heterogeneous amyloid states represents a fundamental event in Alzheimer’s disease. Within these structures oligomeric intermediates are considered to be particularly p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0def00ffff2361063422c5e884ea15
Autor:
Gerd Birkenmeier, Ajeet Rijal Upadhaya, Harshvardhan Rolyan, Dietmar Rudolf Thal, Ann Caroline Feike, Tom Van Dooren, Andreas Waha, Christian Haass, Claus U. Pietrzik, Fred Van Leuven
Publikováno v:
Journal of neural transmission 118(5), 699-712 (2011). doi:10.1007/s00702-010-0572-7
The deposition of amyloid-β protein (Aβ) in the brain is a hallmark of Alzheimer's disease (AD). Apolipoprotein E (apoE) is involved in the clearance of Aβ from brain and the APOE ε4 allele is a major risk factor for sporadic AD. We have recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547f046e8b35a3f570f9c240f9ee7cd3
https://lirias.kuleuven.be/handle/123456789/297698
https://lirias.kuleuven.be/handle/123456789/297698
Autor:
Frank Schnorrer, Pontus Klein, Elisa Motori, Konstanze F. Winklhofer, Cornelia Schönbauer, Rüdiger Klein, Anne Kathrin Müller-Rischart
Publikováno v:
The EMBO journal 33(4), 341-355 (2014). doi:10.1002/embj.201284290
The EMBO Journal
EMBO JOURNAL
The EMBO Journal
EMBO JOURNAL
Synopsis image Glial cell line derived neurotrophic factor (GDNF) improves survival in toxin-models of Parkinson's disease and is currently undergoing clinical development, however the protective mechanism is elusive. This study provides evidence tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ad2f28b140c59168af44036cb9f31c
https://doi.org/10.1002/embj.201470060
https://doi.org/10.1002/embj.201470060
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