Výsledky vyhledávání - "pathology [Neostriatum]"

The role of the striatum in learning to orthogonalize action and valence: A combined PET and 7 T MRI aging study

Autor: Matthew J. Betts, Lieke de Boer, Ivayla Apostolova, Holger Amthauer, Marc Guitart-Masip, Gabriel Ziegler, Coraline D. Metzger, Valentina Perosa, Ralph Buchert, Emrah Düzel

Publikováno v: Cerebral Cortex
Cerebral cortex 30(5), 3340-3351 (2020). doi:10.1093/cercor/bhz313

Pavlovian biases influence instrumental learning by coupling reward seeking with action invigoration and punishment avoidance with action suppression. Using a probabilistic go/no-go task designed to orthogonalize action (go/no-go) and valence (reward

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a745caaf91178c0bda9e6d3abac827c0
https://hdl.handle.net/21.11116/0000-0006-6963-5

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Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice

Autor: Klaus Unsicker, Björn Spittau, Lioudmila Bogatyreva, Venissa Machado, Kerstin Krieglstein, Ralf Gilsbach, Richa Das, Andreas Schober, Dieter Hauschke

Publikováno v: Cell & tissue research 365(2), 209-223 (2016). doi:10.1007/s00441-016-2406-x

Growth/differentiation factor−15 (Gdf-15) is a member of the transforming growth factor-β (Tgf-β) superfamily and has been shown to be a potent neurotrophic factor for midbrain dopaminergic (DAergic) neurons both in vitro and in vivo. Gdf-15 has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb9b7ffdb5b7d12d0172e4d0e24b958
https://doi.org/10.1007/s00441-016-2406-x

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Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice

Autor: Jinhui Ding, Huaibin Cai, David M. Lovinger, Lixin Sun, Jochen Herms, Carmelo Sgobio

Publikováno v: Scientific reports 9(1), 4857 (2019). doi:10.1038/s41598-019-41091-7
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)

Dopamine (DA) release in striatum is functionally segregated across a dorsolateral/ventromedial axis. Interestingly, nigrostriatal DA signaling disruption in Parkinson’s disease (PD) preferentially affects the dorsolateral striatum. The relationshi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da83bd0ca67d4fefa1c3da2359e0f5f2
https://pub.dzne.de/record/140572

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Ventral striatum and stuttering: Robust evidence from a case-control study applying DARTEL

Autor: Bernd Weber, Benjamin Bleek, Martin Reuter, Christian Montag, Thilo Müller, Sebastian Markett, Jennifer Faber

Publikováno v: NeuroImage: Clinical, Vol 23, Iss, Pp-(2019)
NeuroImage: Clinical 23, 101890 (2019). doi:10.1016/j.nicl.2019.101890

A prominent theory of developmental stuttering highlights (dys-)function of the basal ganglia (and in particular the ventral striatum) as a main neural mechanism behind this speech disorder. Although the theory is intriguing, studies on gray matter v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c899f6cc58da4105d5a05459836e9e81
http://www.sciencedirect.com/science/article/pii/S2213158219302402

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Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP

Autor: Donato A. Di Monte, Regina Pape, Stefan Schildknecht, Kim Tieu, Marcel Leist

Publikováno v: Trends in pharmacological sciences 38(6), 541-555 (2017). doi:10.1016/j.tips.2017.03.010

The neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes a Parkinson's disease (PD)-like syndrome by inducing degeneration of nigrostriatal dopaminergic neurons. Studies of the MPTP model have revealed the pathomechanisms underlyi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddbbc214879ae685ab7dadd3aa4847cb
https://pubmed.ncbi.nlm.nih.gov/28442167

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No parkinsonism in SCA2 and SCA3 despite severe neurodegeneration of the dopaminergic substantia nigra

Autor: C. Globas, Wilfred F. A. den Dunnen, Till Karsten Hauser, Kay Seidel, Ewout R. Brunt, Katrin Bürk, Kathrin Brockmann, Matthias Reimold, Ludger Schöls, Horst-Werner Korf, Udo Rüb, Gerald Reischl, Georg Auburger

Publikováno v: Brain, 138. Oxford University Press
Brain 138(11), 3316-3326 (2015). doi:10.1093/brain/awv255

See Klockgether (doi:10.1093/awv253) for a scientific commentary on this article.The spinocerebellar ataxias types 2 (SCA2) and 3 (SCA3) are autosomal dominantly inherited cerebellar ataxias which are caused by CAG trinucleotide repeat expansions in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209c1bec3856c4a7ff69b4c414895769
https://research.rug.nl/en/publications/63404926-14d0-4992-a81f-b45751675396

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