Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex

Autor: Mezydlo, Aleksandra, Treiber, Nils, Kerschensteiner, Martin, Ullrich Gavilanes, Emily, Eichenseer, Katharina, Ancău, Mihai, Wens, Adinda, Ares Carral, Carla, Schifferer, Martina, Snaidero, Nicolas, Misgeld, Thomas

Publikováno v: Neuron 111(11), 1748-1759.e8 (2023). doi:10.1016/j.neuron.2023.03.031

In multiple sclerosis, an inflammatory attack results in myelin loss, which can be partially reversed by remyelination. Recent studies suggest that mature oligodendrocytes could contribute to remyelination by generating new myelin. Here, we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997f7b882b4cb803e4acdf7841faf1a4
https://doi.org/10.1016/j.neuron.2023.03.031

Higher levels of myelin are associated with higher resistance against tau pathology in Alzheimer’s disease

Autor: Rubinski, Anna, Franzmeier, Nicolai, Initiative, Alzheimer’s Disease Neuroimaging, Dewenter, Anna, Luan, Ying, Smith, Ruben, Strandberg, Olof, Ossenkoppele, Rik, Dichgans, Martin, Hansson, Oskar, Ewers, Michael

Publikováno v: Alzheimer’s Disease Neuroimaging Initiative (ADNI) 2022, ' Higher levels of myelin are associated with higher resistance against tau pathology in Alzheimer's disease ', Alzheimer's Research & Therapy, vol. 14, no. 1, 139, pp. 139 . https://doi.org/10.1186/s13195-022-01074-9
Alzheimer's Research & Therapy, 14(1):139. BioMed Central
Alzheimer's research & therapy 14(1), 139 (2022). doi:10.1186/s13195-022-01074-9

Background In Alzheimer’s disease (AD), fibrillar tau initially occurs locally and progresses preferentially between closely connected regions. However, the underlying sources of regional vulnerability to tau pathology remain unclear. Previous brai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2ae32ea067d2f747846ccf77ab1ea1
https://doi.org/10.1186/s13195-022-01074-9

Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis

Autor: Stephan A. Müller, Maria Inês Cunha, Stefan F. Lichtenthaler, Anne Winkler, Bettina Schmid, Franziska van der Meer, Tjakko J. van Ham, Ioannis Alexopoulos, Mikael Simons, Minhui Su, Minou Djannatian, Christine Stadelmann, Martina Schifferer, Ludovico Cantuti-Castelvetri

Publikováno v: Journal of Experimental Medicine, 217(5):e20191390. Rockefeller University Press
The Journal of Experimental Medicine
Journal of experimental medicine 217(5), e20191390 (2020). doi:10.1084/jem.20191390
Journal of Experimental Medicine

We find that pro-inflammatory activation is required for remyelination after myelin injury. We impaired inflammatory signaling and found that microglia in lesioned animals were defective in phagosome maturation, debris clearance, and also in triggeri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8afc169c9da206914a69fcfd5c9cbd3
https://pure.eur.nl/en/publications/92b7bc9e-deb4-4a4e-9a67-9b4171d74756

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Autor: Nicole Schaeren-Wiemers, Marie-Theres Weil, Jeffrey Bennett, Anne Winkler, Martin Kerschensteiner, Mikael Simons, Torben Ruhwedel, Christine Stadelmann, Elisa Romanelli, Lukas Enz, Claudia Wrzos, Klaus-Armin Nave, Norbert Goebels, Wiebke Möbius

Publikováno v: Cell Reports
Cell reports 16(2), 314-322 (2016). doi:10.1016/j.celrep.2016.06.008
Cell Reports, Vol 16, Iss 2, Pp 314-322 (2016)

Summary Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3ceb9355a1e6dbaca77072555126a6

Refining the spectrum of neuronal intranuclear inclusion disease : A case report

Autor: Shami Melhem, Lies Anne Severijnen, John C. van Swieten, Meike W. Vernooij, Harro Seelaar, Renate K. Hukema, Manuela Neumann, Chiara Cupidi, Anke A. Dijkstra, Annemieke J. M. Rozemuller

Publikováno v: Journal of Neuropathology and Experimental Neurology, 78(7), 665. Lippincott Williams and Wilkins
Journal of Neuropathology and Experimental Neurology, 78(7), 665-670. Lippincott Williams and Wilkins
Cupidi, C, Dijkstra, A A, Melhem, S, Vernooij, M W, Severijnen, L-A, Hukema, R K, Rozemuller, A J M, Neumann, M, van Swieten, J C & Seelaar, H 2019, ' Refining the Spectrum of Neuronal Intranuclear Inclusion Disease: A Case Report ', Journal of Neuropathology and Experimental Neurology, vol. 78, no. 7, pp. 665-670 . https://doi.org/10.1093/jnen/nlz043
Journal of neuropathology and experimental neurology 78(7), 665-670 (2019). doi:10.1093/jnen/nlz043
Journal of Neuropathology and Experimental Neurology, 78(7), 665-670. Oxford University Press

Neuronal intranuclear inclusion disease (NIID) is a rare heterogeneous progressive neurodegenerative disease characterized by the presence of eosinophilic hyaline intranuclear inclusions in neuronal and glial cells of the CNS, peripheral cells of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1950c5cfb892a16ed83d52f820a13634
https://doi.org/10.1093/jnen/nlz043