APOE and immunity:Research highlights

Autor: Courtney M. Kloske, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Adam M. Brickman, Guojun Bu, Jessica Dennison, Mary D. Gearon, Alison M. Goate, Christian Haass, Michael T. Heneka, William T. Hu, Lenique K. L. Huggins, Nahdia S. Jones, Radosveta Koldamova, Cynthia A. Lemere, Shane A. Liddelow, Edoardo Marcora, Samuel E. Marsh, Henrietta M. Nielsen, Kellen K. Petersen, Melissa Petersen, Stefanie D. Piña‐Escudero, Wei Qiao Qiu, Yakeel T. Quiroz, Eric Reiman, Claire Sexton, Malú Gámez Tansey, Julia TCW, Charlotte E. Teunissen, Betty M. Tijms, Rik van der Kant, Rebecca Wallings, Stacie C. Weninger, Whitney Wharton, Donna M. Wilcock, Tyler James Wishard, Susan L Worley, Henrik Zetterberg, Maria C. Carrillo

Publikováno v: Kloske, C M, Barnum, C J, Batista, A F, Bradshaw, E M, Brickman, A M, Bu, G, Dennison, J, Gearon, M D, Goate, A M, Haass, C, Heneka, M T, Hu, W T, Huggins, L K L, Jones, N S, Koldamova, R, Lemere, C A, Liddelow, S A, Marcora, E, Marsh, S E, Nielsen, H M, Petersen, K K, Petersen, M, Piña-Escudero, S D, Qiu, W Q, Quiroz, Y T, Reiman, E, Sexton, C, Tansey, M G M, Tcw, J, Teunissen, C E, Tijms, B M, van der Kant, R, Wallings, R, Weninger, S C, Wharton, W, Wilcock, D M, Wishard, T J, Worley, S L, Zetterberg, H & Carrillo, M C 2023, ' APOE and immunity : Research highlights ', Alzheimer's and Dementia, vol. 19, no. 6, pp. 2677-2696 . https://doi.org/10.1002/alz.13020
Alzheimer's and dementia 19(6), 2677-2696 (2023). doi:10.1002/alz.13020
Kloske, C M, Barnum, C J, Batista, A F, Bradshaw, E M, Brickman, A M, Bu, G, Dennison, J, Gearon, M D, Goate, A M, Haass, C, Heneka, M T, Hu, W T, Huggins, L K L, Jones, N S, Koldamova, R, Lemere, C A, Liddelow, S A, Marcora, E, Marsh, S E, Nielsen, H M, Petersen, K K, Petersen, M, Piña-Escudero, S D, Qiu, W Q, Quiroz, Y T, Reiman, E, Sexton, C, Tansey, M G, Tcw, J, Teunissen, C E, Tijms, B M, van der Kant, R, Wallings, R, Weninger, S C, Wharton, W, Wilcock, D M, Wishard, T J, Worley, S L, Zetterberg, H & Carrillo, M C 2023, ' APOE and immunity: Research highlights ', Alzheimer's and Dementia, vol. 19, no. 6, pp. 2677-2696 . https://doi.org/10.1002/alz.13020

INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d9ff92093ab0b6d772041ff569c18f
https://research.vumc.nl/en/publications/823b40ac-c075-4456-8a2d-bdf139906d29

Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy

Autor: Lukas Henning, Henrike Antony, Annika Breuer, Julia Müller, Gerald Seifert, Etienne Audinat, Parmveer Singh, Frederic Brosseron, Michael T. Heneka, Christian Steinhäuser, Peter Bedner

Publikováno v: Glia 71(2), 168-186 (2023). doi:10.1002/glia.24265

Extensive microglia reactivity has been well described in human and experimental temporal lobe epilepsy (TLE). To date, however, it is not clear whether and based on which molecular mechanisms microglia contribute to the development and progression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7febe93f8d8c48e53108d8572a2f2a1d

Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex

Autor: Evelien Van Schoor, Simona Ospitalieri, Sebastiaan Moonen, Sandra O. Tomé, Alicja Ronisz, Orkun Ok, Jochen Weishaupt, Albert C. Ludolph, Philip Van Damme, Ludo Van Den Bosch, Dietmar Rudolf Thal

Publikováno v: Acta neuropathologica 144(3), 393-411 (2022). doi:10.1007/s00401-022-02466-9

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons in the motor cortex, brainstem, and spinal cord. Although ALS is considered a motor neuron disorder, neuroinflammation also plays an important role. Recent evid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3c53395a7b4e2afdc364d08dc754e8
https://pubmed.ncbi.nlm.nih.gov/35867112

Inhibition of microglial β-glucocerebrosidase hampers the microglia-mediated antioxidant and protective response in neurons

Autor: Brunialti, Electra, Villa, Alessandro, Mekhaeil, Marianna, Mornata, Federica, Vegeto, Elisabetta, Maggi, Adriana, Di Monte, Donato A., Ciana, Paolo

Publikováno v: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Journal of neuroinflammation 18(1), 220 (2021). doi:10.1186/s12974-021-02272-2

Background Homozygotic mutations in the GBA gene cause Gaucher’s disease; moreover, both patients and heterozygotic carriers have been associated with 20- to 30-fold increased risk of developing Parkinson’s disease. In homozygosis, these mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dae17a70792272350bc36e176b83fa18
http://europepmc.org/articles/PMC8459568

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease

Autor: Alessandra Webers, Michael T. Heneka, Paul A. Gleeson

Publikováno v: Immunology & cell biology 98(1), 28-41 (2019). doi:10.1111/imcb.12301

Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there has been considerable interest in the role of neuroinflammation in directly contributing to the progression of AD. Stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7712671eb4cc79869a33f467f1eb25
https://doi.org/10.1111/imcb.12301