Transcriptional Signature Derived from Murine Tumor-Associated Macrophages Correlates with Poor Outcome in Breast Cancer Patients

Autor: Theodore S. Kapellos, Cheei-Sing Hau, Thomas Ulas, Lea Seep, Kathrin Klee, Sander Tuit, Karin E. de Visser, Joachim L. Schultze, Marie Oestreich, Camilla Salvagno

Publikováno v: Cell reports 29(5), 1221-1235.e5 (2019). doi:10.1016/j.celrep.2019.09.067
Cell Reports, Vol 29, Iss 5, Pp 1221-1235.e5 (2019)
Cell Reports

Summary Tumor-associated macrophages (TAMs) are frequently the most abundant immune cells in cancers and are associated with poor survival. Here, we generated TAM molecular signatures from K14cre;Cdh1flox/flox;Trp53flox/flox (KEP) and MMTV-NeuT (NeuT

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