Zobrazeno 1 - 4
of 4
pro vyhledávání: '"pathology [Macular Degeneration]"'
Autor:
Tobias Goldmann, Fabio M.V. Rossi, Chotima Böttcher, Peipei Zhang, Jana Koch, Stefaniya Boneva, Ingo Hilgendorf, Ori Staszewski, Takahiro Masuda, Lukas Amann, Peter Wieghofer, Nora Hagemeyer, Josef Priller, Marco Prinz, Roman Sankowski, Clemens Lange, Annika Hausmann, Anja Schlecht, Markus Gruber
Publikováno v:
The EMBO journal 40(6), e105123 (2021). doi:10.15252/embj.2020105123
The EMBO Journal
The EMBO Journal
Similar to the brain, the eye is considered an immune‐privileged organ where tissue‐resident macrophages provide the major immune cell constituents. However, little is known about spatially restricted macrophage subsets within different eye compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ee3b794f53aa607cbde5c2fe0c798b
https://pub.dzne.de/record/164200
https://pub.dzne.de/record/164200
Autor:
Manuela Völkner, Felix Wagner, Lisa Maria Steinheuer, Madalena Carido, Thomas Kurth, Ali Yazbeck, Jana Schor, Stephanie Wieneke, Lynn J. A. Ebner, Claudia Del Toro Runzer, David Taborsky, Katja Zoschke, Marlen Vogt, Sebastian Canzler, Andreas Hermann, Shahryar Khattak, Jörg Hackermüller, Mike O. Karl
Publikováno v:
Nature Communications 13(1), 6183 (2022). doi:10.1038/s41467-022-33848-y
Human organoids could facilitate research of complex and currently incurable neuropathologies, such as age-related macular degeneration (AMD) which causes blindness. Here, we establish a human retinal organoid system reproducing several parameters of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db990db6d94b0c5a875b41b7c561426
https://pubmed.ncbi.nlm.nih.gov/36261438
https://pubmed.ncbi.nlm.nih.gov/36261438
Autor:
Sylvia Bolz, Simon J. Clark, Michela Deleidi, Inga Sonntag, Vasiliki Panagiotakopoulou, Anke Jacob, Sabina Honisch, Ellen Kilger, Marius Ueffing, Angela Armento
Publikováno v:
Scientific Reports
Scientific reports 10(1), 10320 (2020). doi:10.1038/s41598-020-67292-z
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific reports 10(1), 10320 (2020). doi:10.1038/s41598-020-67292-z
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Polymorphisms in the Complement Factor H (CFH) gene, coding for the Factor H protein (FH), can increase the risk for age-related macular degeneration (AMD). AMD-associated CFH risk variants, Y402H in particular, impair FH function leading to compleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b7a6a57d9bcee7f8d8cf617090f2b6
https://pubmed.ncbi.nlm.nih.gov/32587311
https://pubmed.ncbi.nlm.nih.gov/32587311
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Journal of molecular medicine 93(8), 905-916 (2015). doi:10.1007/s00109-015-1275-1
Journal of molecular medicine 93(8), 905-916 (2015). doi:10.1007/s00109-015-1275-1
Photooxidative damage and chronic innate immune activation have been implicated in retinal pigment epithelium (RPE) dysfunction, a process that underlies blinding diseases such as age-related macular degeneration (AMD). To identify a potential molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad98583a96c15961a6c403d4763e16b
http://europepmc.org/articles/PMC4510924
http://europepmc.org/articles/PMC4510924