Systemically administered neuregulin-1β1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson's disease

Autor: Thomas W. Rösler, Wolfgang H. Oertel, Candan Depboylu, Günter U. Höglinger, Anderson de Andrade

Publikováno v: Journal of neurochemistry 133(4), 590-597 (2015). doi:10.1111/jnc.13026

Previously, we demonstrated that systemically injected extracellular domain of neuregulin-1β1 (Nrg1β1), a nerve growth and differentiation factor, passes the blood-brain barrier and rescues dopaminergic neurons of substantia nigra in the 6-hydroxyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5bab3ff3500e4ff65eb72552b0850c
https://doi.org/10.1111/jnc.13026

Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease

Autor: Josef Priller, Sarah Stricker, Wolfgang H. Oertel, Günter U. Höglinger, Jean-Pierre Ghobril, Candan Depboylu

Publikováno v: Experimental neurology 238(2), 183-191 (2012). doi:10.1016/j.expneurol.2012.08.020

Parkinson disease (PD) is characterized by dopaminergic neurodegeneration in the substantia nigra (SN). Recent evidence suggests that innate and adaptive immune responses can influence dopaminergic cell death in animal models of PD. However, the prec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388f96d46b0631fa4105d973a5d50551
https://pubmed.ncbi.nlm.nih.gov/22964486

Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP

Autor: Luca Giovanni Di Giovannantonio, Antonio Simeone, Wolfgang Wurst, Raffaele Prosperi, Dario Acampora, Daniela Omodei, Michela Di Salvio, Nilima Prakash

Publikováno v: Nature neuroscience
13 (2010): 1481–1488. doi:10.1038/nn.2661
info:cnr-pdr/source/autori:Di Salvio M.; Di Giovannantonio L.G.; Acampora D.; Prosperi R.; Omodei D.; Prakash N.; Wurst W.; Simeone A./titolo:Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP/doi:10.1038%2Fnn.2661/rivista:Nature neuroscience (Print)/anno:2010/pagina_da:1481/pagina_a:1488/intervallo_pagine:1481–1488/volume:13
Nature reviews / Neuroscience 13(12), 1481-1488 (2010). doi:10.1038/nn.2661
Nature Neuroscience; Vol 13

Mesencephalic-diencephalic dopaminergic neurons control locomotor activity and emotion and are affected in neurodegenerative and psychiatric diseases. The homeoprotein Otx2 is restricted to ventral tegmental area (VTA) neurons that are prevalently co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06928c2ccaedce1ec00354e5a4fe1e79
https://publications.cnr.it/doc/27006