Zobrazeno 1 - 10 of 19 pro vyhledávání: '"pathology [Kidney]"'
1
Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation
Autor: Thimoteus Speer, Anna Paschen, Joachim Jankowski, David Schmit, Lucia Rohrer, Eicke Latz, Sarah Triem, Willi Jahnen-Dechent, Jochen Reiser, Vera Jankowski, Barbara A. Niemeyer, Gunter Aßmann, Gerhard M. Kostner, Michael D. Menger, Christina Körbel, Danilo Fliser, Stephen Zewinger, Susanne Schuster, Rafael Kramann, Michael Böhm, Simina-Ramona Selejan, Manfred Kopf, Winfried März, Ulrich Laufs, Dalia Alansary, Mira Klug, Eunsil Hahm, Tobias Herter, Günther Silbernagel, Robert Bals, Martina Sester, Urban Sester, Emmanuel Ampofo, Stefan J Schunk, Matthias W. Laschke
Publikováno v: Nature Immunology, 21(1), 30-+. Nature Publishing Group
Nature immunology 21(1), 30-41 (2019). doi:10.1038/s41590-019-0548-1
Nature Immunology, 21(1), 30-41. Nature Publishing Group
NLRP3-inflammasome-driven inflammation is involved in the pathogenesis of a variety of diseases. Identification of endogenous inflammasome activators is essential for the development of new anti-inflammatory treatment strategies. Here, we identified
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f4f8bbeae748a0cac86e45204497f6
https://cris.maastrichtuniversity.nl/en/publications/ebd63dda-1451-4416-9dff-90b522012719
Zobrazit plný text záznamu
2
IL-18 (Interleukin-18) produced by renal tubular epithelial cells promotes renal inflammation and injury during deoxycorticosterone/salt-induced hypertension in mice
Autor: Narbada Saini, Prerna Sharma, Shalini M Krishnan, Tomasz J. Guzik, Ashley Mansell, Christopher G. Sobey, Brooke M. Huuskes, Yeong H Ling, Henry Diep, Paul M. O'Connor, Grant R Drummond, Maria Jelinic, Antony Vinh, Eicke Latz, Jordyn Michele Thomas, Michael J. Hickey, Thiruma V. Arumugam, Dorota Ferens, Barbara K Kemp-Harper
Publikováno v: Hypertension 78(5), 1296-1309 (2021). doi:10.1161/HYPERTENSIONAHA.120.16437
IL-18 (interleukin-18) is elevated in hypertensive patients, but its contribution to high blood pressure and end-organ damage is unknown. We examined the role of IL-18 in the development of renal inflammation and injury in a mouse model of low-renin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395ca8a80826136e2d6c0288057f4eb5
https://ruj.uj.edu.pl/xmlui/handle/item/283355
Zobrazit plný text záznamu
3
Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension
Autor: Grant R Drummond, Shalini M Krishnan, Brooke M. Huuskes, Narbada Saini, Ashley Mansell, Antony Vinh, Christopher T. Chan, Avril A. B. Robertson, Christopher G. Sobey, Henry Diep, Mark E. Cooper, Chrishan S. Samuel, Yeong H Ling, Dorota Ferens, Barbara K Kemp-Harper, Michelle M Kett, Karlheinz Peter, Eicke Latz
Publikováno v: Cardiovascular Research
Cardiovascular research 115(4), 776-787 (2018). doi:10.1093/cvr/cvy252
Aims Renal inflammation, leading to fibrosis and impaired function is a major contributor to the development of hypertension. The NLRP3 inflammasome mediates inflammation in several chronic diseases by processing the cytokines pro-interleukin (IL)-1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d951b009b6ef65ac77456a5ffe1a26c
https://doi.org/10.1093/cvr/cvy252
Zobrazit plný text záznamu
4
In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria
Autor: Juan Antonio Aguilar-Pimentel, Thomas Klopstock, Eckhard Wolf, Carsten B. Schmidt-Weber, Julia Calzada-Wack, Ralph Fingerhut, Lore Becker, Marie Lucienne, Valerie Gailus-Durner, D. Sean Froese, Nadine Spielmann, Wolfgang Wurst, Philipp Mayer-Kuckuk, Birgit Rathkolb, Lillian Garrett, Martin Hrabě de Angelis, Déborah Mathis, Jan Rozman, Matthias R. Baumgartner, Merima Forny, Dirk H. Busch, Irina Treise, Patricia da Silva-Buttkus, Helmut Fuchs, Oana V. Amarie, Sabine M. Hölter
Publikováno v: Biochimica et biophysica acta / Molecular basis of disease 1866(3), 165622 (2020). doi:10.1016/j.bbadis.2019.165622
Biochim. Biophys. Acta-Mol. Basis Dis. 1866:165622 (2020)
Isolated methylmalonic aciduria (MMAuria) is primarily caused by deficiency of methylmalonyl-CoA mutase (MMUT or MUT). Biochemically, MUT deficiency results in the accumulation of methylmalonic acid (MMA), propionyl-carnitine (C3) and other metabolit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c74a41bb0ba27f5045f882d95511bc
Zobrazit plný text záznamu
5
Increased compensatory kidney workload results in cellular damage in a short time porcine model of mixed acidemia - Is acidemia a 'first hit' in acute kidney injury?
Autor: Russ, Martin, Ott, Sascha, Bedarf, Janis R., Kirschfink, Michael, Hiebl, Bernhard, Unger, Juliane K.
Publikováno v: PLOS ONE 14(6), e0218308 (2019). doi:10.1371/journal.pone.0218308
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218308 (2019)
Acute kidney injury (AKI) corrupts the outcome of about 50% of all critically ill patients. We investigated the possible contribution of the pathology acidemia on the development of AKI. Pigs were exposed to acidemia, acidemia plus hypoxemia or a nor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6993d01a96784dfa3ea7da71e3ef14eb
Zobrazit plný text záznamu
6
Glycine amidinotransferase (GATM), renal Fanconi syndrome, and kidney failure
Autor: Mahim Jain, Daniela Iancu, Joana Raquel Martins, Robert J. Unwin, Kathrin Renner, Naomi Issler, Chi-Un Choe, Hannes Doellerer, Ralph Witzgall, Stephen B. Walsh, Sulochana Devi, Monika Mozere, Robert Kleta, Johann M.B Simbuerger, Kevin O'Brien, Anne Kesselheim, Markus Reichold, Paldeep S. Atwal, Michael Kasgharian, Uta Lichter-Konecki, William A. Gahl, Carlos Ferreira, Julia Wiesner, Vaksha Patel, Horia Stanescu, Peter J. Oefner, Graciana Jaureguiberry, Christopher W. Pugh, Mario Milani, Joerg Reinders, Christina Sterner, Detlef Bockenhauer, Sue Povey, Simona Dumitriu, Chris Laing, Ben Davies, Carsten Broeker, David S. Konecki, Roland Schmitt, Alexander Hammers, Richard Sandford, Enriko Klootwijk, Dirk Isbrandt, Richard Warth, Daniel P. Gale, Andrew M. Hall, Alberto Cebrian-Serrano, Alexander J. Howie, Weibin Zhou, Geoffrey Charles-Edwards, Ines Tegtmeier, Edgar A. Otto, Mehmet Tekman, Katja Dettmer
Publikováno v: Journal of the American Society of Nephrology 29(7), 1849-1858 (2018). doi:10.1681/ASN.2017111179
Journal of the American Society of Nephrology 29 (2018): 1849–1858. doi:10.1681/ASN.2017111179
info:cnr-pdr/source/autori:Reichold M, Klootwijk ED, Reinders J, Otto EA, Milani M, Broeker C, Laing C, Wiesner J, Devi S, Zhou W, Schmitt R, Tegtmeier I, Sterner C, Doellerer H, Renner K, Oefner PJ, Dettmer K, Simbuerger JM, Witzgall R, Stanescu HC, Dumitriu S, Iancu D, Patel V, Mozere M, Tekman M, Jaureguiberry G, Issler N, Kesselheim A, Walsh SB, Gale DP, Howie AJ, Martins JR, Hall AM, Kasgharian M, O'Brien K, Ferreira CR, Atwal PS, Jain M, Hammers A, Charles-Edwards G, Choe CU, Isbrandt D, Cebrian-Serrano A, Davies B, Sandford RN, Pugh C, Konecki DS, Povey S, Bockenhauer D, Lichter-Konecki U, Gahl WA, Unwin RJ, Warth R, Kleta R/titolo:Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure/doi:10.1681%2FASN.2017111179/rivista:Journal of the American Society of Nephrology/anno:2018/pagina_da:1849/pagina_a:1858/intervallo_pagine:1849–1858/volume:29
Background For many patients with kidney failure, the cause and underlying defect remain unknown. Here, we describe a novel mechanism of a genetic order characterized by renal Fanconi syndrome and kidney failure. Methods We clinically and genetically
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baaa6ddb5c84630d07d85e382ece0673
https://doi.org/10.1681/asn.2017111179
Zobrazit plný text záznamu
7
Overexpression of Membrane-Bound Fas Ligand (CD95L) Exacerbates Autoimmune Disease and Renal Pathology in Pristane-Induced Lupus
Autor: Katherine A. Fitzgerald, Adam R. Wespiser, Lukas Bossaller, Ramon G. Bonegio, Daniel R. Caffrey, Vijay A. K. Rathinam, Quan Zhen Li, Ann Marshak-Rothstein, Ping I. Chiang, Eicke Latz, Patricia Busto, Chandra Mohan
Publikováno v: The journal of immunology 191(5), 2104-2114 (2013). doi:10.4049/jimmunol.1300341
Loss-of-function mutations in the Fas death receptor or its ligand result in a lymphoproliferative syndrome and exacerbate clinical disease in most lupus-prone strains of mice. One exception is mice injected with 2,6,10,14-tetramethylpentadecane (TMP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8001f00c2ed4f2c679649ab4ed10bda
https://doi.org/10.4049/jimmunol.1300341
Zobrazit plný text záznamu
8
Soluble Uric Acid Activates the NLRP3 Inflammasome
Autor: Mariana Rodrigues Davanso, Maria Fernanda Forni, Bernardo S. Franklin, Tarcio Teodoro Braga, Alicia J. Kowaltowski, Niels Olsen Saraiva Camara, José Alexandre Marzagão Barbuto, Meire Ioshie Hiyane, Rodrigo Nalio Ramos, Angela Castoldi, Matheus Correa-Costa, Eicke Latz, Paola Cristina Branco
Publikováno v: Scientific reports 7(1), 39884 (2017). doi:10.1038/srep39884
Scientific Reports
7:39884
Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome. Soluble uric acid (sUA) is found in high concentrations in the serum of gre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803859049bae3e25ec8f546f6f541705
Zobrazit plný text záznamu
9
Review
Diagnostic Pathology: Kidney Diseases.
Autor: Barisoni, Laura1
Publikováno v: Kidney International. Apr2012, Vol. 81 Issue 8, p715-717. 3p.
Zobrazit plný text záznamu
10
Impact of N-Acetylcysteine on cerebral amyloid-β plaques and kidney damage in spontaneously hypertensive stroke-prone rats
Autor: Cornelia Garz, Roxana O. Carare, Stefanie Schreiber, Hans-Jochen Heinze, Luiza Stanaszek, Klaus G. Reymann, Solveig Niklass, Wolfgang Härtig, Siegfried Kropf, Celine Z. Bueche, Daniel Bittner
Publikováno v: Journal of Alzheimer's disease 42(s3), S305-S313 (2014). doi:10.3233/JAD-132615
Background Cerebral small vessel disease (CSVD) in spontaneously hypertensive stroke prone rats (SHRSP) is accompanied by parenchymal amyloid-β (Aβ) deposition in the brain and by hypertensive nephropathy with tubulointerstitial damage. N-acetylcys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc5f891430f5713c81ec69cdca7c00e
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje