Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients

Autor: Tobias M. Böckers, Albert C. Ludolph, Jan Kassubek, David Bayer, Luc Dupuis, Hans-Peter Müller, Stefano Antonucci, Volker Rasche, Rami Saad, Francesco Roselli

Publikováno v: Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-17 (2021)
Translational Neurodegeneration
Translational Neurodegeneration, [London] : BioMed Central, 2012-, 2021, 10 (1), pp.17. ⟨10.1186/s40035-021-00241-6⟩
Translational Neurodegeneration, 2021, 10 (1), pp.17. ⟨10.1186/s40035-021-00241-6⟩
Translational neurodegeneration 10(1), 17 (2021). doi:10.1186/s40035-021-00241-6

Background Increased catabolism has recently been recognized as a clinical manifestation of amyotrophic lateral sclerosis (ALS). The hypothalamic systems have been shown to be involved in the metabolic dysfunction in ALS, but the exact extent of hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975db4967a8ff48ee26982bd77308f6e
https://doaj.org/article/a6593394dc8947b5b66f4a710304a553

Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis

Autor: Vercruysse, Pauline, Sinniger, Jérôme, Dreyhaupt, Jens, Grehl, Torsten, Hermann, Andreas, Grosskreutz, Julian, Witting, Anke, Van Den Bosch, Ludo, Spreux-Varoquaux, Odile, Group, GERP ALS Study, Ludolph, Albert C, Dupuis, Luc, El Oussini, Hajer, Borisow, Nadja, Holm, Theresa, Maier, Andre, Meyer, Thomas, Budde, Paula, Gruhn, Kai, Bewersdorff, Malte, Heneka, Michael, Storch, Alexander, Scekic-Zahirovic, Jelena, Frank, Tobias, Göricke, Bettina, Weishaupt, Jochen, Eger, Katharina, Hanisch, Frank, Zierz, Stephan, Boeck, Anna-Lena, Dengler, Reinhard, Koerner, Sonja, Kollewe, Katja, Dieterlé, Stéphane, Petri, Susanne, Prell, Tino, Ringer, Thomas, Zinke, Jan, Anneser, Johanna, Borasio, Gian Domenico, Chahli, Christine, Winkler, Andrea S, Boentert, Matthias, Stubbe-Draeger, Bianca, Young, Peter, Bogdahn, Ulrich, Franz, Steffen, Haringer, Verena, Weidner, Norbert, Benecke, Reiner, Meister, Stefanie, Prudlo, Johannes, Wittstock, Matthias, Dorst, Johannes, Hendrich, Corinna, Sperfeld, Anne-Dorte, Weiland, Ulrike, Neidhardt, Sabine, Schrank, Berthold, Beck, Marcus, Kraft, Peter, Toyka, Klaus, Ulzheimer, Jochen, Wessig, Carsten, Kassubek, Jan, Fischer, Wilhelm

Publikováno v: Brain 139(4), 1106-1122 (2016). doi:10.1093/brain/aww004
Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2016, 139 (4), pp.1106-1122. ⟨10.1093/brain/aww004⟩
Brain-A Journal of Neurology, 2016, 139 (4), pp.1106-1122. ⟨10.1093/brain/aww004⟩

International audience; Amyotrophic lateral sclerosis, the most common adult-onset motor neuron disease, leads to death within 3 to 5 years after onset. Beyond progressive motor impairment, patients with amyotrophic lateral sclerosis suffer from majo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2100cab1af8c6c87b161388fec439336
https://pubmed.ncbi.nlm.nih.gov/26984187