Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy

Autor: James D. Mills, Eleonora Aronica, Wim Van Hecke, Till S. Zimmer, Stefanie Dedeurwaerdere, Johannes C. Baayen, Sander Idema, Nicole N. van der Wel, Anatoly Korotkov, Jonathan van Eyll, Peter C. van Rijen, Rainer Surges, Erwin A. van Vliet, Helmut W. Kessels, Jan A. Gorter, Diede W. M. Broekaart, Angelika Mühlebner, Martin Schidlowski, Theodor Rüber, Bastian David, Gabriele Ruffolo, Liesbeth François

Publikováno v: Acta Neuropathologica, 142(4), 729-759. Springer Verlag
Acta neuropathologica 142(4), 729-759 (2021). doi:10.1007/s00401-021-02348-6
Acta neuropathologica, 142(4), 729-759. Springer Verlag
Acta Neuropathologica

Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, to date, alterations in iron metabolism in the epilep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b82eaadc30bc3f4a002607a77dba8b4
https://doi.org/10.1007/s00401-021-02348-6

The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects

Autor: Elodie Chabrol, Roger Prades, Anatoly Korotkov, Oleg Senkov, Shaobo Jia, Johannes C. Baayen, Jan A. Gorter, Diede W. M. Broekaart, Alexander Dityatev, Wytse J. Wadman, Sander Idema, Jasper J. Anink, Alexandra Bertran, Erwin A. van Vliet, Eleonora Aronica, Albert J. Becker, James D. Mills, Jesús Seco, Anika Bongaarts, Teresa Tarragó

Publikováno v: Journal of Clinical Investigation, 131(1):e138332. The American Society for Clinical Investigation
Broekaart, D W M, Bertran, A, Jia, S, Korotkov, A, Senkov, O, Bongaarts, A, Mills, J D, Anink, J J, Seco, J, Baayen, J C, Idema, S, Chabrol, E, Becker, A J, Wadman, W J, Tarragó, T, Gorter, J A, Aronica, E, Prades, R, Dityatev, A & van Vliet, E A 2021, ' The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects ', Journal of Clinical Investigation, vol. 131, no. 1, e138332 . https://doi.org/10.1172/JCI138332
J Clin Invest
The journal of clinical investigation 131(1), e138332 (2021). doi:10.1172/JCI138332
Journal of clinical investigation, 131(1):e138332. The American Society for Clinical Investigation
The journal of clinical investigation, 131(1):e138332. The American Society for Clinical Investigation

Matrix metalloproteinases (MMPs) are synthesized by neurons and glia and released into the extracellular space, where they act as modulators of neuroplasticity and neuroinflammatory agents. Development of epilepsy (epileptogenesis) is associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba82be954946800f57c88d15af875b95
https://research.vumc.nl/en/publications/7ff5ba3a-afb5-4d69-ba8a-c911324843ff

LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention

Autor: Atsushi Nambu, Makoto Sanbo, Xiumin Chen, Yuko Fukata, Harald Prüss, Hans-Christian Kornau, Hiroki Inahashi, Masumi Hirabayashi, Teppei Goto, Roger A. Nicoll, Yoko Hirano, Atsushi Yamagata, Satomi Chiken, Masaki Fukata, Shuya Fukai, Hiromi Sano

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 118(3), e2022580118-(2021). doi:10.1073/pnas.2022580118
Proceedings of the National Academy of Sciences of the United States of America

Significance This study addresses a fundamental question in neuroscience, namely how does the presynaptic component of the synapse precisely align with the postsynaptic component? This is essential for the proper transmission of signals across the sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68628950b12bc111c5ad4ecbb0ec6b28

Evidence for peri-ictal blood-brain barrier dysfunction in patients with epilepsy

Autor: Gottfried Schlaug, Guido Lüchters, Bernd Weber, Elke Hattingen, Alon Friedman, Christian E. Elger, Robert D. Nass, Rainer Surges, Bastian David, Tony Stöcker, Theodor Rüber, Ralf Deichmann

Publikováno v: Brain 141(10), 2952-2965 (2018). doi:10.1093/brain/awy242

Epilepsy has been associated with a dysfunction of the blood-brain barrier. While there is ample evidence that a dysfunction of the blood-brain barrier contributes to epileptogenesis, blood-brain barrier dysfunction as a consequence of single epilept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba31eddcb13958e778b00a300a21d964
https://pub.dzne.de/record/140260

Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy

Autor: Christian Steinhäuser, Michel K. Herde, Martin K. Schwarz, Tingsong Li, Peter Bedner, Tushar Deshpande, Albert J. Becker, Hartmut Vatter, Christian Henneberger

Publikováno v: Glia 65(11), 1809-1820 (2017). doi:10.1002/glia.23196

Dysfunctional astrocytes are increasingly recognized as key players in the development and progression of mesial temporal lobe epilepsy (MTLE). One of the dramatic changes astrocytes undergo in MTLE with hippocampal sclerosis (HS) is loss of gap junc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a52549dc975ec149670fe2c64680ce
https://pubmed.ncbi.nlm.nih.gov/28795432