Zobrazeno 1 - 7
of 7
pro vyhledávání: '"pathology [Down Syndrome]"'
Autor:
Annus, Tiina, Wilson, Liam R., Acosta-Cabronero, Julio, Cardenas-Blanco, Arturo, Hong, Young T., Fryer, Tim D., Coles, Jonathan P., Menon, David K., Zaman, Shahid H., Holland, Anthony J., Nestor, Peter J.
Publikováno v:
Neurobiology of aging 53, 11-19 (2017). doi:10.1016/j.neurobiolaging.2017.01.009
Neurobiology of Aging
Neurobiology of Aging
People with Down syndrome (DS) have a neurodevelopmentally distinct brain and invariably developed amyloid neuropathology by age 50. This cross-sectional study aimed to provide a detailed account of DS brain morphology and the changes occuring with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::63b7e55f23abc0a336807769911cf737
Autor:
Cole, James H., Annus, Tiina, Wilson, Liam R., Remtulla, Ridhaa, Hong, Young T., Fryer, Tim D., Acosta-Cabronero, Julio, Cardenas-Blanco, Arturo, Smith, Robert, Menon, David K., Zaman, Shahid H., Nestor, Peter J., Holland, Anthony J.
Publikováno v:
Neurobiology of Aging
Neurobiology of aging 56, 41-49 (2017). doi:10.1016/j.neurobiolaging.2017.04.006
Cole, J H, Annus, T, Wilson, L R, Remtulla, R, Hong, Y T, Fryer, T D, Acosta-Cabronero, J, Cardenas-Blanco, A, Smith, R, Menon, D K, Zaman, S H, Nestor, P J & Holland, A J 2017, ' Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline ', Neurobiology of Aging, vol. 56, pp. 41-49 . https://doi.org/10.1016/j.neurobiolaging.2017.04.006
Neurobiology of aging 56, 41-49 (2017). doi:10.1016/j.neurobiolaging.2017.04.006
Cole, J H, Annus, T, Wilson, L R, Remtulla, R, Hong, Y T, Fryer, T D, Acosta-Cabronero, J, Cardenas-Blanco, A, Smith, R, Menon, D K, Zaman, S H, Nestor, P J & Holland, A J 2017, ' Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline ', Neurobiology of Aging, vol. 56, pp. 41-49 . https://doi.org/10.1016/j.neurobiolaging.2017.04.006
Individuals with Down syndrome (DS) are more likely to experience earlier onset of multiple facets of physiological aging. This includes brain atrophy, beta amyloid deposition, cognitive decline, and Alzheimer's disease—factors indicative of brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07cbe3c2014b61e2dfc7fdde2641d08
http://europepmc.org/articles/PMC5476346
http://europepmc.org/articles/PMC5476346
Autor:
Wirths, Oliver, Walter, Susanne, Kraus, Inga, Klafki, Hans W., Stazi, Martina, Oberstein, Timo J., Ghiso, Jorge, Wiltfang, Jens, Bayer, Thomas A., Weggen, Sascha
Publikováno v:
Alzheimer's research & therapy 9(1), 80 (2017). doi:10.1186/s13195-017-0309-z
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2017)
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2017)
Alzheimer's Research & Therapy
Background The deposition of neurotoxic amyloid-β (Aβ) peptides in plaques in the brain parenchyma and in cerebral blood vessels is considered to be a key event in Alzheimer’s disease (AD) pathogenesis. Although the presence and impact of full-le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ff885ce55204eefef9daf60f129cc9d5
http://resolver.sub.uni-goettingen.de/purl?gs-1/15154
http://resolver.sub.uni-goettingen.de/purl?gs-1/15154
Autor:
Annus, Tiina, Wilson, Liam R., Hong, Young T., Acosta–Cabronero, Julio, Fryer, Tim D., Cardenas–Blanco, Arturo, Smith, Robert, Boros, Istvan, Coles, Jonathan P., Aigbirhio, Franklin I., Menon, David K., Zaman, Shahid H., Nestor, Peter J., Holland, Anthony J.
Publikováno v:
Alzheimer's and dementia 12(5), 538-545 (2015). doi:10.1016/j.jalz.2015.07.490
Alzheimer's & Dementia
Alzheimer's & Dementia
INTRODUCTION: Adults with Down syndrome (DS) invariably develop Alzheimer's disease (AD) neuropathology. Understanding amyloid deposition in DS can yield crucial information about disease pathogenesis. METHODS: Forty-nine adults with DS aged 25-65 un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cdbc8c4514f26dfefd394a8a2b1c5d26
https://www.repository.cam.ac.uk/handle/1810/250293
https://www.repository.cam.ac.uk/handle/1810/250293
Publikováno v:
Head, Elizabeth; Lott, Ira T; Wilcock, Donna M; & Lemere, Cynthia A. (2016). Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology.. Current Alzheimer research, 13(1), 18-29. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/20c4c1wp
Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to play a critical role in the development of AD neuropathology. The overexpression of the gene for the amyloid precursor protein (APP), on chromosome 21, leads to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469b440125ce833414fdb990519bd2d8
http://www.escholarship.org/uc/item/20c4c1wp
http://www.escholarship.org/uc/item/20c4c1wp
Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease
Autor:
Martin, Sarah B, Dowling, Amy L S, Lianekhammy, Joann, Lott, Ira T, Doran, Eric, Murphy, M Paul, Beckett, Tina L, Schmitt, Frederick A, Head, Elizabeth
Publikováno v:
Martin, Sarah B; Dowling, Amy L S; Lianekhammy, Joann; Lott, Ira T; Doran, Eric; Murphy, M Paul; et al.(2014). Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease.. Journal of Alzheimer's disease : JAD, 42(3), 767-775. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/4fj1n9fx
Adults with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by 40 years of age. Synaptophysin (SYN) consistently declines with age and is further reduced with sporadic AD. Thus, we hypothesized that SYN would be reduced in DS with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::ebcbc0a168ad1631ded68bd2e0c579a0
http://www.escholarship.org/uc/item/4fj1n9fx
http://www.escholarship.org/uc/item/4fj1n9fx
Autor:
Harry LeVine, Ira T. Lott, Michael Paul Murphy, Amy L.S. Dowling, D. Allan Butterfield, Tina L. Beckett, Cesare Mancuso, Elizabeth Head, Frederick A. Schmitt, Giovanna Cenini, Eugenio Barone
Publikováno v:
Cenini, Giovanna; Dowling, Amy L S; Beckett, Tina L; Barone, Eugenio; Mancuso, Cesare; Murphy, Michael Paul; et al.(2012). Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome.. Biochimica et biophysica acta, 1822(2), 130-138. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/5k03z6vd
Down syndrome (DS) is the most common genetic cause of intellectual disability in children, and the number of adults with DS reaching old age is increasing. By the age of 40years, virtually all people with DS have sufficient neuropathology for a post
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4292c03a590cb173f983b64413964d98