Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice

Autor: Laura Malz, Eva M Szego, Nadine Bernhardt, Angela Rösen-Wolff, Björn H Falkenburger, Hella Luksch

Publikováno v: eLife 11, e81943 (2022). doi:10.7554/eLife.81943

Stimulator of interferon genes (STING) is activated after detection of cytoplasmic dsDNA by cGAS (cyclic GMP-AMP synthase) as part of the innate immunity defence against viral pathogens. STING binds TANK-binding kinase 1 (TBK1). TBK1 mutations are as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ebd0eda879f38af5d4f9039f24f7b0
https://pubmed.ncbi.nlm.nih.gov/36314770

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

Autor: Yanina Dening, Theresa Straßl, Viktoria Ruf, Petra Dirscherl, Alexandra Chovsepian, Alicia Stievenard, Amit Khairnar, Felix Schmidt, Florian Giesert, Jochen Herms, Johannes Levin, Marianne Dieterich, Peter Falkai, Daniela Vogt Weisenhorn, Wolfgang Wurst, Armin Giese, Francisco Pan-Montojo

Publikováno v: Sci. Rep. 12:21951 (2022)
Scientific reports 12(1), 21951 (2022). doi:10.1038/s41598-022-25790-2

Parkinson′s disease (PD) pathology progresses throughout the nervous system affecting numerous neuronal structures. It has been postulated that the progression of the pathology is based on a prion-like disease mechanism partly due to the seeding ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a1684d991f4a1f1cd6f04c1b9b3b07
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=67079

Parkinson's disease and translational research

Autor: Elisabeth Dinter, Björn H. Falkenburger, Theodora Saridaki, Leonie Diederichs, Heinz Reichmann

Publikováno v: Translational Neurodegeneration
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-11 (2020)
Translational neurodegeneration 9(1), 43 (2020). doi:10.1186/s40035-020-00223-0

Parkinson’s disease (PD) is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity, and when these symptoms respond to dopaminergic medications. Yet in the last years there was a greater recognition of additional aspects of the di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa942a5c52f8fe75b2fd89ccdcf704f7
https://pubmed.ncbi.nlm.nih.gov/33256849

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

Autor: Sigrun Nestel, Silvia De Cicco, Vasiliki Panagiotakopoulou, Cong Yu, David C. Schöndorf, Michela Deleidi, Lukas Kristoffer Schwarz, Ivana Giunta, Oliver Bandmann, Thomas Gasser, Bernd Heimrich, Pascale Baden, Jan Pruszak, Gabriele Di Napoli, Marcus Keatinge, Alexander J. Whitworth, Alvaro Sanchez-Martinez, Dina Ivanyuk

Publikováno v: Cell reports 23(10), 2976-2988 (2018). doi:10.1016/j.celrep.2018.05.009

While mitochondrial dysfunction is emerging as key in Parkinson's disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23332f701e589a7a2b4f378a16eaf621
https://doi.org/10.1016/j.celrep.2018.05.009

Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity

Autor: Giovanna Ambrosini, Ina Schmitt, Ullrich Wüllner, Naoki Osato, Philipp Bucher, Hongde Liu, Tikam Chand Dakal, Amit Sharma, Shailendra Asthana

Publikováno v: Scientific reports 9(1), 18464 (2019). doi:10.1038/s41598-019-54865-w
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports

Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6a32195c571ce4385be42c7fe9b66a