Zobrazeno 1 - 10
of 21
pro vyhledávání: '"pathology [Brain Ischemia]"'
Autor:
Tatjana Rundek, Ona Wu, Ramesh Sridharan, Vincent Thijs, Marco Nardin, Daniel Woo, Bradford B. Worrall, Christina Jern, Ralph L. Sacco, Steven J. T. Mocking, Pankaj Sharma, Agnieszka Slowik, Steven J. Kittner, Anne-Katrin Giese, Braxton D. Mitchell, Elissa C. McIntosh, Jordi Jimenez-Conde, Markus D. Schirmer, Polina Golland, John W. Cole, Arne Lindgren, Robin Lemmens, Adrian V. Dalca, Eva Giralt-Steinhauer, Dawn Kleindorfer, Reinhold Schmidt, Natalia S. Rost, Jonathan Rosand, Patrick F. McArdle, Johan Wassélius, Huichun Xu, James F. Meschia, Robert E. Irie, Kathleen L. Donahue
Publikováno v:
Neurology 95(1), e79-e88 (2020). doi:10.1212/WNL.0000000000009728
Neurology
Neurology
ObjectiveTo examine etiologic stroke subtypes and vascular risk factor profiles and their association with white matter hyperintensity (WMH) burden in patients hospitalized for acute ischemic stroke (AIS).MethodsFor the MRI Genetics Interface Explora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6166f6af647911d062d09aaeb935f5cf
https://doi.org/10.1212/wnl.0000000000009728
https://doi.org/10.1212/wnl.0000000000009728
Autor:
Kathrin Klee, Dagmar Schütz, Praveen Ashok Kumar, Thomas Ulas, Christoph Redecker, Friederike Saaber, Yves Werner, Frederic Geissmann, Amelie Lupp, Elvira Mass, Joachim L. Schultze, Kristian Händler, Ralf Stumm, Arik Horne
Publikováno v:
Nature neuroscience 23(3), 351-362 (2020). doi:10.1038/s41593-020-0585-y
Nat Neurosci
Nat Neurosci
Monocyte-derived and tissue-resident macrophages are ontogenetically distinct components of the innate immune system. Assessment of their respective functions in pathology is complicated by changes to the macrophage phenotype during inflammation. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af428157e8243870e5dce4666f5473e1
https://doi.org/10.1038/s41593-020-0585-y
https://doi.org/10.1038/s41593-020-0585-y
Autor:
Jan Meyer, Niklas J. Gerkau, Karl W. Kafitz, Matthias Patting, Fabian Jolmes, Christian Henneberger, Christine R. Rose
Publikováno v:
The journal of neuroscience 42(4), 552-566 (2021). doi:10.1523/JNEUROSCI.0819-21.2021
J Neurosci
J Neurosci
Fluorescence imaging is an indispensable method for analysis of diverse cellular and molecular processes, enabling, for example, detection of ions, second messengers, or metabolites. Intensity-based approaches, however, are prone to artifacts introdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f3adb9969e8f875b239e3d6231c96f
https://pub.dzne.de/record/163301
https://pub.dzne.de/record/163301
Autor:
Golo Kronenberg, Karen Gertz, Burcu Ersoy, Valérie Boujon, Stephanie Wegner, Matthias Endres, Ria Uhlemann
Publikováno v:
Molecular Neurobiology
Molecular neurobiology 57(3), 1446-1458 (2019). doi:10.1007/s12035-019-01822-3
Molecular neurobiology 57(3), 1446-1458 (2019). doi:10.1007/s12035-019-01822-3
Vascular mechanisms underlying the adverse effects that depression and stress-related mental disorders have on stroke outcome are only partially understood. Identifying the transcriptomic signature of chronic stress in endothelium harvested from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07147bb1f02f08ffafe9d3d279e8e51d
http://europepmc.org/articles/PMC7060977
http://europepmc.org/articles/PMC7060977
Autor:
Clemens Messerschmidt, Marco Foddis, Sonja Blumenau, Susanne Müller, Kajetan Bentele, Manuel Holtgrewe, Celia Kun-Rodrigues, Isabel Alonso, Maria do Carmo Macario, Ana Sofia Morgadinho, Ana Graça Velon, Gustavo Santo, Isabel Santana, Saana Mönkäre, Liina Kuuluvainen, Johanna Schleutker, Minna Pöyhönen, Liisa Myllykangas, Assunta Senatore, Daniel Berchtold, Katarzyna Winek, Andreas Meisel, Aleksandra Pavlovic, Vladimir Kostic, Valerija Dobricic, Ebba Lohmann, Hasmet Hanagasi, Gamze Guven, Basar Bilgic, Jose Bras, Rita Guerreiro, Dieter Beule, Ulrich Dirnagl, Celeste Sassi
Publikováno v:
Scientific reports 11(1), 6072 (2021). doi:10.1038/s41598-021-84919-x
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Recently, several genome-wide association studies identified PHACTR1 as key locus for five diverse vascular disorders: coronary artery disease, migraine, fibromuscular dysplasia, cervical artery dissection and hypertension. Although these represent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d760b308229fb529960863502c733cd1
https://refubium.fu-berlin.de/handle/fub188/38139
https://refubium.fu-berlin.de/handle/fub188/38139
Autor:
Adam Denes, Nicolai Franzmeier, Steffanie Heindl, Olga Carofiglio, Thomas Arzberger, Peter T. Nelson, Nikolett Lénárt, Alessio Ricci, Tibor Hortobágyi, Arthur Liesz, Dieter Edbauer, Qihui Zhou, Ann M. Stowe
Publikováno v:
Journal of Experimental Medicine
Journal of experimental medicine 218(8), e20202411 (2021). doi:10.1084/jem.20202411
The Journal of Experimental Medicine
Journal of experimental medicine 218(8), e20202411 (2021). doi:10.1084/jem.20202411
The Journal of Experimental Medicine
Heindl et al. describe the local proliferation and clustering of T cells in the brain of mice and humans after stroke. This previously unrecognized phenomenon could explain why blocking cerebral leukocyte invasion might fail to improve long-term stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85b3077423c61350254debe6602a6ad
Autor:
Keith W. Muir, Martin Ebinger, Christian Gerloff, Thies Ingwersen, Salvador Pedraza, Alina Königsberg, Claus Z Simonsen, Götz Thomalla, Josep Puig, Eckhard Schlemm, Jochen B. Fiebach, Jens Fiehler, Anke Wouters, Bastian Cheng, Vincent Thijs, Ivana Galinovic, Matthias Endres, Florent Boutitie, Robin Lemmens, Norbert Nighoghossian
Publikováno v:
Nature Communications 12(1), 2590 (2021). doi:10.1038/s41467-021-22786-w
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2590. ⟨10.1038/s41467-021-22786-w⟩
Nature Communications, 2021, 12 (1), pp.2590. ⟨10.1038/s41467-021-22786-w⟩
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Schlemm, E, Ingwersen, T, Königsberg, A, Boutitie, F, Ebinger, M, Endres, M, Fiebach, J B, Fiehler, J, Galinovic, I, Lemmens, R, Muir, K W, Nighoghossian, N, Pedraza, S, Puig, J, Simonsen, C Z, Thijs, V, Wouters, A, Gerloff, C, Thomalla, G & Cheng, B 2021, ' Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke ', Nature Communications, vol. 12, no. 1, 2590 . https://doi.org/10.1038/s41467-021-22786-w
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2590. ⟨10.1038/s41467-021-22786-w⟩
Nature Communications, 2021, 12 (1), pp.2590. ⟨10.1038/s41467-021-22786-w⟩
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Schlemm, E, Ingwersen, T, Königsberg, A, Boutitie, F, Ebinger, M, Endres, M, Fiebach, J B, Fiehler, J, Galinovic, I, Lemmens, R, Muir, K W, Nighoghossian, N, Pedraza, S, Puig, J, Simonsen, C Z, Thijs, V, Wouters, A, Gerloff, C, Thomalla, G & Cheng, B 2021, ' Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke ', Nature Communications, vol. 12, no. 1, 2590 . https://doi.org/10.1038/s41467-021-22786-w
Thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke aims to restore compromised blood flow and prevent further neuronal damage. Despite the proven clinical efficacy of this treatment, little is known about the short-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4157e758454a7f30cb973ccad7559ebd
https://pubmed.ncbi.nlm.nih.gov/33972513
https://pubmed.ncbi.nlm.nih.gov/33972513
Autor:
Lilian Staerck, Golo Kronenberg, Helmut Kettenmann, Friederike Klempin, Stephanie Wegner, Karen Gertz, Wolfgang Uckert, Nadine Richter, Matthias Endres, Ria Uhlemann, Susanne A. Wolf
Publikováno v:
Acta neuropathologica 135(4), 551-568 (2017). doi:10.1007/s00401-017-1795-6
After stroke, macrophages in the ischemic brain may be derived from either resident microglia or infiltrating monocytes. Using bone marrow (BM)-chimerism and dual-reporter transgenic fate mapping, we here set out to delimit the responses of either ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a437546f0aa140714a4c266aabf7cc
https://doi.org/10.1007/s00401-017-1795-6
https://doi.org/10.1007/s00401-017-1795-6
Publikováno v:
Glia 65(9), 1550-1561 (2017). doi:10.1002/glia.23183
Glia
Glia
Stroke is one of the leading causes of death and long-term disability. In the penumbra, that is, the area surrounding the infarct core, peri-infarct depolarizations (PIDs) are accompanied by strong intracellular calcium elevations in astrocytes and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588e1d215ae13eaf7c5463da0f71b6aa
https://doi.org/10.1002/glia.23183
https://doi.org/10.1002/glia.23183
Autor:
Jochner, Magdalena C. E., An, Junfeng, Lättig-Tünnemann, Gisela, Kirchner, Marieluise, Dagane, Alina, Dittmar, Gunnar, Dirnagl, Ulrich, Eickholt, Britta J., Harms, Christoph
Publikováno v:
Scientific reports 9(1), 3183 (2019). doi:10.1038/s41598-019-39438-1
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Phosphatase and tensin homolog (PTEN) signalling might influence neuronal survival after brain ischemia. However, the influence of the less studied longer variant termed PTEN-L (or PTENα) has not been studied to date. Therefore, we examined the tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe3fd8a0d22d61bec4055744e1803c1
http://edoc.mdc-berlin.de/18081/1/18081oa.pdf
http://edoc.mdc-berlin.de/18081/1/18081oa.pdf