Zobrazeno 1 - 10
of 236
pro vyhledávání: '"parent of origin effect"'
Autor:
Joseph P. Garner, Catherine F. Talbot, Laura A. Del Rosso, Brenda McCowan, Sreetharan Kanthaswamy, David Haig, John P. Capitanio, Karen J. Parker
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Background Quantitative autistic traits are common, heritable, and continuously distributed across the general human population. Patterns of autistic traits within families suggest that more complex mechanisms than simple Mendelian inheritan
Externí odkaz:
https://doaj.org/article/66985ff1e8f3428f867269f0231816c5
Autor:
Chenhao Gao, Carmen Amador, Rosie M. Walker, Archie Campbell, Rebecca A. Madden, Mark J. Adams, Xiaomeng Bai, Ying Liu, Miaoxin Li, Caroline Hayward, David J. Porteous, Xueyi Shen, Kathryn L. Evans, Chris S. Haley, Andrew M. McIntosh, Pau Navarro, Yanni Zeng
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-28 (2023)
Abstract Background The variation in the rate at which humans age may be rooted in early events acting through the genomic regions that are influenced by such events and subsequently are related to health phenotypes in later life. The parent-of-origi
Externí odkaz:
https://doaj.org/article/b78a5a466ff14b5192c67c87ae1821d6
Autor:
Ron Nudel, Richard Zetterberg, Nicoline Hemager, Camilla A. J. Christiani, Jessica Ohland, Birgitte K. Burton, Aja N. Greve, Katrine S. Spang, Ditte Ellersgaard, Ditte L. Gantriis, Jonas Bybjerg-Grauholm, Kerstin J. Plessen, Jens Richardt M. Jepsen, Anne A. E. Thorup, Thomas Werge, Ole Mors, Merete Nordentoft
Publikováno v:
Behavioral and Brain Functions, Vol 18, Iss 1, Pp 1-20 (2022)
Abstract Many psychiatric and neurodevelopmental disorders are known to be heritable, but studies trying to elucidate the genetic architecture of such traits often lag behind studies of somatic traits and diseases. The reasons as to why relatively fe
Externí odkaz:
https://doaj.org/article/4f1a024a208b40f1825edea88d60028b
Akademický článek
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Autor:
Juan F Macias-Velasco, Celine L St Pierre, Jessica P Wayhart, Li Yin, Larry Spears, Mario A Miranda, Caryn Carson, Katsuhiko Funai, James M Cheverud, Clay F Semenkovich, Heather A Lawson
Publikováno v:
eLife, Vol 11 (2022)
Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and neurological traits. Parent-of-origin effects can be modified by the environment, but the architecture of these gene-by-environmental effects on phenotypes re
Externí odkaz:
https://doaj.org/article/544b0a3b284647ab9a32696c108eb34a
Keeping Track of the Genealogy of Heterozygotes Using Epigenetic Reference Codes and Breeding Tables
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2022)
Studying neurobehavioral consequences of the hypofunctional dopamine transporter (DAT) across several generations entails the need to monitor allelic transmission to offspring, taking into account both maternal and paternal inheritance. Since each ty
Externí odkaz:
https://doaj.org/article/a9e8e638858340a69df7d60dd4ada5e2
Autor:
Yanni Zeng, Carmen Amador, Chenhao Gao, Rosie M. Walker, Stewart W. Morris, Archie Campbell, Azra Frkatović, Rebecca A Madden, Mark J. Adams, Shuai He, Andrew D. Bretherick, Caroline Hayward, David J. Porteous, James F. Wilson, Kathryn L. Evans, Andrew M. McIntosh, Pau Navarro, Chris S. Haley
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103730- (2021)
Background: parent-of-origin effects (POE) play important roles in complex disease and thus understanding their regulation and associated molecular and phenotypic variation are warranted. Previous studies mainly focused on the detection of genomic re
Externí odkaz:
https://doaj.org/article/074223ccfeb54427999eb66fd69ca4a5
Autor:
Hye In Kim, Bin Ye, Jeffrey Staples, Anthony Marcketta, Chuan Gao, Alan R. Shuldiner, Cristopher V. Van Hout
Publikováno v:
HGG Advances, Vol 2, Iss 3, Pp 100039- (2021)
Summary: Parent-of-origin (PoO) effects refer to the differential phenotypic impacts of genetic variants dependent on their parental inheritance due to imprinting. While PoO effects can influence complex traits, they may be poorly captured by models
Externí odkaz:
https://doaj.org/article/f2947829020e440683383da35b914525
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Anna Brancato, Sara L. M. Lo Russo, Anna Sara Liberati, Cristiana Carbone, Silvia Zelli, Giovanni Laviola, Carla Cannizzaro, Walter Adriani
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 778 (2021)
Social interaction is essential for life but is impaired in many psychiatric disorders. We presently focus on rats with a truncated allele for dopamine transporter (DAT). Since heterozygous individuals possess only one non-mutant allele, epigenetic i
Externí odkaz:
https://doaj.org/article/22a4f21afa46464481f04354d97a3379