Zobrazeno 1 - 10
of 124
pro vyhledávání: '"parasporin"'
Autor:
Juan S. Alarcón-Aldana, Lydia Visser, Nohora J. Rueda-Forero, Efraín H. Pinzón-Reyes, Paola Rondón-Villarreal, Miguel O. Suárez-Barrera
Publikováno v:
Toxins, Vol 16, Iss 10, p 415 (2024)
Parasporin PS2Aa1, recently renamed Mpp46Aa1, is an anti-cancer protein known for its selectivity against various human cancer cell lines. We genetically modified native PS2Aa1 to create a library of approximately 100 mutants. From this library, we s
Externí odkaz:
https://doaj.org/article/7e05bea37a0547889b30b7c2ecc8855d
Akademický článek
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Autor:
Miguel O. Suárez-Barrera, Lydia Visser, Efraín H. Pinzón-Reyes, Paola Rondón Villarreal, Juan S. Alarcón-Aldana, Nohora Juliana Rueda-Forero
Publikováno v:
Molecules, Vol 27, Iss 21, p 7262 (2022)
Parasporin 2 has cytotoxic effects against numerous colon cancer cell lines, making it a viable alternative to traditional treatments. However, its mechanism of action and receptors remain unknown. In this study, site-directed mutagenesis was used to
Externí odkaz:
https://doaj.org/article/7c0083f7fba34da59302ca3939227d4e
Probing the Mechanism of Action of Cry41Aa on HepG2 through the Establishment of a Resistant Subline
Autor:
Wided Souissi, Tweedie Alistair, Barbara Domanska, Eva Fortea, Michelle J. West, Jean-Louis Schwartz, Neil Crickmore
Publikováno v:
Toxins, Vol 14, Iss 5, p 319 (2022)
Cry41Aa, also called parasporin-3, belongs to a group of toxins from the entomopathogenic bacterium Bacillus thuringiensis that show activity against human cancer cells. Cry41Aa exhibits preferential cytocidal activity towards HL-60 (human promyelocy
Externí odkaz:
https://doaj.org/article/5f9f4924240f4dfbb286378236fce861
Akademický článek
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Akademický článek
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Publikováno v:
Toxins, Vol 6, Iss 9, Pp 2732-2770 (2014)
Since the first X-ray structure of Cry3Aa was revealed in 1991, numerous structures of B. thuringiensis toxins have been determined and published. In recent years, functional studies on the mode of action and resistance mechanism have been proposed,
Externí odkaz:
https://doaj.org/article/9b1696f9005749dfb756d20b2329490a
Publikováno v:
Toxins, Vol 6, Iss 7, Pp 2115-2126 (2014)
Parasporin-4 (PS4) is an aerolysin-type β-pore-forming toxin produced by Bacillus thuringiensis strain A1470. It exhibits specific cytotoxicity against human cancer cell lines; therefore, it is expected to be useful for the diagnosis and treatment o
Externí odkaz:
https://doaj.org/article/0019f87308694cf483910f95ef64a049
Autor:
Keisuke Ekino, Shiro Okumura, Tomoyuki Ishikawa, Sakae Kitada, Hiroyuki Saitoh, Tetsuyuki Akao, Takuji Oka, Yoshiyuki Nomura, Michio Ohba, Takashi Shin, Eiichi Mizuki
Publikováno v:
Toxins, Vol 6, Iss 6, Pp 1882-1895 (2014)
Parasporin is the cytocidal protein present in the parasporal inclusion of the non-insecticidal Bacillus thuringiensis strains, which has no hemolytic activity but has cytocidal activities, preferentially killing cancer cells. In this study, we chara
Externí odkaz:
https://doaj.org/article/e64ac958d8e241efac2f2047faa572f2
Autor:
Mourad A. M. Aboul-Soud, Mohammed Z. Al-Amri, Ashok Kumar, Yazeed A. Al-Sheikh, Abdelkader E. Ashour, Talat A. El-Kersh
Publikováno v:
Molecules, Vol 24, Iss 3, p 506 (2019)
Currently, global efforts are being intensified towards the discovery of local Bacillus thuringiensis (Bt) isolates with unique anticancer properties. Parasporins (PS) are a group of Bt non-insecticidal crystal proteins with potential and specific in
Externí odkaz:
https://doaj.org/article/22cfb41a3f344a7c94ef7b0575ea4cd0