Výsledky vyhledávání - "parallel fibers"

Akademický článek

A maximum of two readily releasable vesicles per docking site at a cerebellar single active zone synapse

Autor: Melissa Silva, Van Tran, Alain Marty

Publikováno v: eLife, Vol 12 (2024)

Recent research suggests that in central mammalian synapses, active zones contain several docking sites acting in parallel. Before release, one or several synaptic vesicles (SVs) are thought to bind to each docking site, forming the readily releasabl

Externí odkaz: https://doaj.org/article/851b4db2534145c0be30dc060be3ba67

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Akademický článek

The m6A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons

Autor: Jun Yu, Yuanchu She, Lixin Yang, Mengru Zhuang, Peng Han, Jianhui Liu, Xiaoyan Lin, Nijia Wang, Mengxian Chen, Chunxuan Jiang, Yujia Zhang, Yujing Yuan, Sheng‐Jian Ji

Publikováno v: Advanced Science, Vol 8, Iss 22, Pp n/a-n/a (2021)

Abstract Messenger RNA m6A modification is shown to regulate local translation in axons. However, how the m6A codes in axonal mRNAs are read and decoded by the m6A reader proteins is still unknown. Here, it is found that the m6A readers YTHDF1 and YT

Externí odkaz: https://doaj.org/article/29ce9c74894b42f3ab2f35e0c7393669

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Akademický článek

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Akademický článek

Calcium Imaging Reveals Coordinated Simple Spike Pauses in Populations of Cerebellar Purkinje Cells

Autor: Jorge E. Ramirez, Brandon M. Stell

Publikováno v: Cell Reports, Vol 17, Iss 12, Pp 3125-3132 (2016)

The brain’s control of movement is thought to involve coordinated activity between cerebellar Purkinje cells. The results reported here demonstrate that somatic Ca2+ imaging is a faithful reporter of Na+-dependent “simple spike” pauses and enab

Externí odkaz: https://doaj.org/article/0e67e18638834a1d985a42498e168212

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Akademický článek

Characteristic Eye Movements in Ataxia-Telangiectasia-Like Disorder: An Explanatory Hypothesis

Autor: Pamela Federighi, Stefano Ramat, Francesca Rosini, Elena Pretegiani, Antonio Federico, Alessandra Rufa

Publikováno v: Frontiers in Neurology, Vol 8 (2017)

ObjectiveTo investigate cerebellar dysfunctions and quantitatively characterize specific oculomotor changes in ataxia-telangiectasia-like disorder (ATLD), a rare autosomal recessive disease caused by mutations in the MRE11 gene. Additionally, to furt

Externí odkaz: https://doaj.org/article/661061252abe4460b32572608291c963

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Akademický článek

Frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity

Autor: Frédéric Doussau, Hartmut Schmidt, Kevin Dorgans, Antoine M Valera, Bernard Poulain, Philippe Isope

Publikováno v: eLife, Vol 6 (2017)

The segregation of the readily releasable pool of synaptic vesicles (RRP) in sub-pools that are differentially poised for exocytosis shapes short-term plasticity. However, the frequency-dependent mobilization of these sub-pools is poorly understood.

Externí odkaz: https://doaj.org/article/ae2db80c8d7a4ec4870543bff33b7f83

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