Zobrazeno 1 - 10
of 559
pro vyhledávání: '"paolo arosio"'
Autor:
Itzel Condado-Morales, Fabian Dingfelder, Isabel Waibel, Oliver M. Turnbull, Bhargav Patel, Zheng Cao, Jais Rose Bjelke, Susanne Nedergaard Grell, Anja Bennet, Alissa M. Hummer, Matthew I. J. Raybould, Charlotte M. Deane, Thomas Egebjerg, Nikolai Lorenzen, Paolo Arosio
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Engineered antibody formats, such as antibody fragments and bispecifics, have the potential to offer improved therapeutic efficacy compared to traditional full-length monoclonal antibodies (mAbs). However, the translation of these non-natural molecul
Externí odkaz:
https://doaj.org/article/902ae4a0e4394deeb9b5cd245a0a3c88
Autor:
Marcos Gil-Garcia, Ana I. Benítez-Mateos, Marcell Papp, Florence Stoffel, Chiara Morelli, Karl Normak, Katarzyna Makasewicz, Lenka Faltova, Francesca Paradisi, Paolo Arosio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The mechanisms that underlie the regulation of enzymatic reactions by biomolecular condensates and how they scale with compartment size remain poorly understood. Here we use intrinsically disordered domains as building blocks to generate pro
Externí odkaz:
https://doaj.org/article/eb5c8469e8814035ba495ac4c22d5bbb
Autor:
Ayush K. Srivastava, Aliaksandra A. Reutovich, Nathan J. Hunter, Paolo Arosio, Fadi Bou-Abdallah
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Ferritin is a ubiquitous intracellular iron storage protein that plays a crucial role in iron homeostasis. Animal tissue ferritins consist of multiple isoforms (or isoferritins) with different proportions of H and L subunits that contribute
Externí odkaz:
https://doaj.org/article/0ec83e8949494934b78127fd60be7757
Autor:
Fabian Wirth, Fabrice D. Heitz, Christine Seeger, Ioana Combaluzier, Karin Breu, Heather C. Denroche, Julien Thevenet, Melania Osto, Paolo Arosio, Julie Kerr-Conte, C. Bruce Verchere, François Pattou, Thomas A. Lutz, Marc Y. Donath, Christoph Hock, Roger M. Nitsch, Jan Grimm
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose. Beta cell dysfunction and loss is associated with an accumulation of aggregated
Externí odkaz:
https://doaj.org/article/68eb80d31bdf42208e648a12724a93bf
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody drugs should exhibit not only high-binding affinity for their target antigens but also favorable physicochemical drug-like properties. Such drug-like biophysical properties are essential for the successful development of antibody dru
Externí odkaz:
https://doaj.org/article/375ca2578f7d4343a49f80dafa044d39
Autor:
Silvia Locarno, Paolo Arosio, Francesca Curtoni, Marco Piazzoni, Emanuele Pignoli, Salvatore Gallo
Publikováno v:
Gels, Vol 10, Iss 3, p 172 (2024)
In recent decades, hydrogels have emerged as innovative soft materials with widespread applications in the medical and biomedical fields, including drug delivery, tissue engineering, and gel dosimetry. In this work, a comprehensive study of the macro
Externí odkaz:
https://doaj.org/article/70f461592856433ab1d6cdf6090e2037
Autor:
Miriam Linsenmeier, Maria Hondele, Fulvio Grigolato, Eleonora Secchi, Karsten Weis, Paolo Arosio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Here the authors analyze material properties and aging of active phase-separated condensates by Differential Dynamic Microscopy. Arrested states are promoted by structured RNA. Low-complexity domains and biochemical reaction keep the droplets fluid-l
Externí odkaz:
https://doaj.org/article/37e5083619774cda9c11b6dec46c61b4
Autor:
Mohamed Boumaiza, Imene Fhoula, Fernando Carmona, Maura Poli, Michela Asperti, Alessandra Gianoncelli, Michela Bertuzzi, Paolo Arosio, Mohamed Nejib Marzouki
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 1, Pp 117-127 (2021)
Hepcidin and ferritin are key proteins of iron homeostasis in mammals. In this study, we characterize a chimera by fusing camel hepcidin to a human ferritin H-chain to verify if it retained the properties of the two proteins. The construct (HepcH) is
Externí odkaz:
https://doaj.org/article/594eb4e0579f424daf244d1d7b59759c
Autor:
Francesca Brero, Paola Calzolari, Martin Albino, Antonio Antoccia, Paolo Arosio, Francesco Berardinelli, Daniela Bettega, Mario Ciocca, Angelica Facoetti, Salvatore Gallo, Flavia Groppi, Claudia Innocenti, Anna Laurenzana, Cristina Lenardi, Silvia Locarno, Simone Manenti, Renato Marchesini, Manuel Mariani, Francesco Orsini, Emanuele Pignoli, Claudio Sangregorio, Francesca Scavone, Ivan Veronese, Alessandro Lascialfari
Publikováno v:
Nanomaterials, Vol 13, Iss 5, p 791 (2023)
We present an investigation of the effects on BxPC3 pancreatic cancer cells of proton therapy combined with hyperthermia, assisted by magnetic fluid hyperthermia performed with the use of magnetic nanoparticles. The cells’ response to the combined
Externí odkaz:
https://doaj.org/article/e7cc51f6543f4d8fb957f02a0ab1cb4c
Autor:
Francesca Brero, Paolo Arosio, Martin Albino, Davide Cicolari, Margherita Porru, Martina Basini, Manuel Mariani, Claudia Innocenti, Claudio Sangregorio, Francesco Orsini, Alessandro Lascialfari
Publikováno v:
Nanomaterials, Vol 13, Iss 5, p 804 (2023)
We investigated the effect of different organic coatings on the 1H-NMR relaxation properties of ultra-small iron-oxide-based magnetic nanoparticles. The first set of nanoparticles, with a magnetic core diameter ds1 = 4.4 ± 0.7 nm, was coated with po
Externí odkaz:
https://doaj.org/article/05b5431622f5478ba06fcded134565ca