Zobrazeno 1 - 10
of 226
pro vyhledávání: '"pMMR"'
Autor:
Fengyun Pei, Wan He, Yinghua Duan, Qijun Yao, Yandong Zhao, Xinjuan Fan, Shuai Liu, Haiyang Chen, Fang He, Tingzhi Liu, Jiaoting Chen, Yijia Zheng, Heping Li, Xiaofang Guo, Lishuo Shi, Li Ling, Yaoxu Chen, Jiapeng He, Miao Liu, Mengli Huang, Yuezong Bai, Jianping Wang, Meijin Huang, Jun Huang
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Background Patients with DNA mismatch repair‐proficient/microsatellite stable (pMMR/MSS) colorectal cancer (CRC), which accounts for 85% of all CRC cases, display a poor respond to immune checkpoint inhibitors (i.e., anti‐PD‐1 antibodi
Externí odkaz:
https://doaj.org/article/478e2f55036f4d94b5bcf65305acb66a
Autor:
Huijing Feng, Siyuan Zhang, Qiuru Zhou, Fei Han, Gang Du, Lin Wang, Xuena Yang, Xiying Zhang, Wenwen Yu, Feng Wei, Xishan Hao, Xiubao Ren, Hua Zhao
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/f8768b0408e9465f80dcb861774fc246
Autor:
Huijing Feng, Siyuan Zhang, Qiuru Zhou, Fei Han, Gang Du, Lin Wang, Xuena Yang, Xiying Zhang, Wenwen Yu, Feng Wei, Xishan Hao, Xiubao Ren, Hua Zhao
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundImmune checkpoint therapy, involving the programmed cell death 1 (PD-1) monoclonal antibody, has revolutionized the treatment of cancer. Tertiary lymphatic structure (TLS) serves as an immune indicator to predict the efficacy of PD-1 antibo
Externí odkaz:
https://doaj.org/article/1f9ec80b5f7c424e89c63f3c9c039bc9
Publikováno v:
BMC Immunology, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Purpose This study was designed to investigate the efficacy and safety of immune checkpoint inhibitors (ICIs)-based therapy in proficient mismatch repair (pMMR)/non-microsatellite instability-high (non-MSI-H) metastatic colorectal cancer (mC
Externí odkaz:
https://doaj.org/article/6f653b40304b48deb2d030d662cf097f
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
BackgroundPulmonary enteric adenocarcinoma (PEAC) is a rare histological subtype of non-small-cell lung cancer (NSCLC) with a predominant (>50%) enteric differentiation component. The frequency of high microsatellite instability (MSI-H) is very low i
Externí odkaz:
https://doaj.org/article/24f4b69951464fedaf9ebaabef041d13
Publikováno v:
Forensic Science International: Reports, Vol 8, Iss , Pp 100345- (2023)
A 61-year-old man was found dead on the terrace in front of his house. The body showed external signs of advanced (Grade 4) putrefaction. Routine post-mortem computed tomography (PMCT) was conducted prior to the forensic autopsy showing a radiologica
Externí odkaz:
https://doaj.org/article/1e10bdf0982f480596cf8feab74159ff
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e22092- (2023)
Colorectal cancer (CRC) is one of the most common malignancies, and at the initial visit, most patients are diagnosed with metastatic CRC (mCRC). However, immunotherapy is only and highly effective in a very small proportion of patients with mCRC hav
Externí odkaz:
https://doaj.org/article/1e9f42b8b3224d18a2951f785bf92054
Autor:
Joel Yambert, Leigh A. Henricksen, June Clements, Andrew Hannon, Alyssa Jordan, Shalini Singh, Katerina Dvorak, Colin C. Pritchard, Eric Q. Konnick
Publikováno v:
Journal of Molecular Pathology, Vol 3, Iss 4, Pp 339-354 (2022)
Background and Aims: Multiple laboratory methods are used to screen patients with colorectal cancer (CRC) for mismatch repair (MMR) protein deficiency to identify possible Lynch syndrome patients. The goal of this study was to compare the agreement b
Externí odkaz:
https://doaj.org/article/7fd268f18b5b40ef9ff4f2f9eb7651fc
Autor:
YIN Zhucheng, LIANG Xinjun
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 49, Iss 9, Pp 977-981 (2022)
In recent years, immunotherapy has achieved great progress in the treatment of malignant tumors and has enriched the treatment mode of many types of malignant tumors. Colorectal cancer is a common tumor worldwide. Immune checkpoint inhibitor therapy
Externí odkaz:
https://doaj.org/article/abc2befa116948f195ff04c8d6fa9ab1
Autor:
Marine Jary, Wen‐Wei Liu, Dongyao Yan, Isaac Bai, Andrea Muranyi, Elise Colle, Isabelle Brocheriou, Anthony Turpin, Nina Radosevic‐Robin, Pierre Bourgoin, Frédérique Penault‐Llorca, Romain Cohen, Dewi Vernerey, Thierry André, Christophe Borg, Kandavel Shanmugam, Magali Svrcek
Publikováno v:
Molecular Oncology, Vol 16, Iss 11, Pp 2260-2273 (2022)
In the era of immune checkpoint inhibitors, understanding the metastatic microenvironment of proficient mismatch repair/microsatellite stable (pMMR/MSS) colorectal cancer (CRC) is of paramount importance to both prognostication and the development of
Externí odkaz:
https://doaj.org/article/528753a036b940b0a01d68a276c317a4