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pro vyhledávání: '"p62/SQSTM1"'
Publikováno v:
Livers, Vol 4, Iss 3, Pp 377-387 (2024)
Acetaminophen (APAP) overdose can induce hepatocyte necrosis and acute liver failure in experimental rodents and humans. APAP is mainly metabolized via hepatic cytochrome P450 enzymes to generate the highly reactive metabolite N-acetyl-p-benzoquinone
Externí odkaz:
https://doaj.org/article/64659b169e2942ee823e5360833d3c20
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 6868-6884 (2024)
The onset of neurodegenerative diseases involves a complex interplay of pathological mechanisms, including protein aggregation, oxidative stress, and impaired autophagy. This review focuses on the intricate connection between oxidative stress and aut
Externí odkaz:
https://doaj.org/article/1047f23f8ad542a5b4a7c33b1f154c8a
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Arginyltransferase (Ate1) orchestrates posttranslational protein arginylation, a pivotal regulator of cellular proteolytic processes. In eukaryotic cells, two interconnected systems—the ubiquitin proteasome system (UPS) and macr
Externí odkaz:
https://doaj.org/article/80774d2b7ef044ca81148c1ba202484a
Autor:
Muthita Hirunsai, Ratchakrit Srikuea
Publikováno v:
Physiological Reports, Vol 12, Iss 8, Pp n/a-n/a (2024)
Abstract Renin–angiotensin system activation contributes to skeletal muscle atrophy in aging individuals with chronic diseases. We aimed to explore the effects of cholecalciferol (VD3) and calcitriol (1,25VD3) on signaling of muscle proteolysis and
Externí odkaz:
https://doaj.org/article/013f928789014125a9dce7144d1c3a5d
Autor:
Andrea Arena, Maria Anele Romeo, Rossella Benedetti, Maria Saveria Gilardini Montani, Roberta Santarelli, Roberta Gonnella, Gabriella D’Orazi, Mara Cirone
Publikováno v:
Discover Oncology, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract NRF2 is a transcription factor that plays a pivotal role in carcinogenesis, also through the interaction with several pro-survival pathways. NRF2 controls the transcription of detoxification enzymes and a variety of other molecules impinging
Externí odkaz:
https://doaj.org/article/15bcc674e8b744f682571bc4ce72aa38
Autor:
Samantha Acevedo, Alejandra A. Covarrubias, Paola Haeger, Floria Pancetti, Fadia Tala, Erwin de la Fuente-Ortega
Publikováno v:
Antioxidants, Vol 13, Iss 5, p 618 (2024)
Gastric diseases represent a significant global public health challenge, characterized by molecular dysregulation in redox homeostasis and heightened oxidative stress. Although prior preclinical studies have demonstrated the cytoprotective antioxidan
Externí odkaz:
https://doaj.org/article/5e5f5d97d32442ed9991643744dc28db
Publikováno v:
Cells, Vol 12, Iss 24, p 2838 (2023)
Advanced glycation end-products (AGEs), formed through glyceraldehyde (GA) as an intermediate in non-enzymatic reactions with intracellular proteins, are cytotoxic and have been implicated in the pathogenesis of various diseases. Despite their signif
Externí odkaz:
https://doaj.org/article/14ba11bbbf7642c68b82c91671b79c6a
Akademický článek
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Akademický článek
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Autor:
Benjamin G. Trist, Jennifer A. Fifita, Alison Hogan, Natalie Grima, Bradley Smith, Claire Troakes, Caroline Vance, Christopher Shaw, Safa Al-Sarraj, Ian P. Blair, Kay L. Double
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Multiple neurotoxic proteinopathies co-exist within vulnerable neuronal populations in all major neurodegenerative diseases. Interactions between these pathologies may modulate disease progression, suggesting they may constitute targets for
Externí odkaz:
https://doaj.org/article/6009cd789000488891a5da5a25f5909a