Zobrazeno 1 - 10
of 745
pro vyhledávání: '"p53-MDM2"'
Autor:
Joana Moreira, Joana B. Loureiro, Danilo Correia, Andreia Palmeira, Madalena M. Pinto, Lucília Saraiva, Honorina Cidade
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1354 (2023)
We previously reported that chalcone CM-M345 (1) and diarylpentanoid BP-C4 (2) induced p53-dependent growth inhibitory activity in human cancer cells. Herein, CM-M345 (1) and BP-C4 (2) analogues were designed and synthesized in order to obtain more p
Externí odkaz:
https://doaj.org/article/8786cacc1ddf46e7a76db44d185ae506
Publikováno v:
Results in Physics, Vol 40, Iss , Pp 105856- (2022)
The p53 oscillator is an essential cell fate controller after DNA damage. In general, the delayed p53-Mdm2 negative feedback loop is thought to be the foundational structure responsible for p53 oscillations. However, it is experimentally found that M
Externí odkaz:
https://doaj.org/article/e1cf0f0ed0234ed9a2f38ad909ca67ca
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5578-5588 (2021)
SIRT1 is a multifunctional deacetylase that participates in a variety of cellular physiological processes to cope with stress. The anticancer protein P53 is an important target of SIRT1. It has been found that SIRT1 is involved in apoptosis by regula
Externí odkaz:
https://doaj.org/article/5f17c0c7dcd14ed39bccae8e7491b3f4
Publikováno v:
Mathematical Biosciences and Engineering, Vol 17, Iss 4, Pp 3794-3835 (2020)
In this paper, a delayed mathematical model for the P53-Mdm2 network is developed. The P53-Mdm2 network we study is triggered by growth factor instead of DNA damage and the amount of DNA damage is regarded as zero. We study the influences of time del
Externí odkaz:
https://doaj.org/article/ee2a264fc5de439bb1da019b3f88a15d
Akademický článek
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Autor:
Elisa Nuti, Valeria La Pietra, Simona Daniele, Doretta Cuffaro, Lidia Ciccone, Chiara Giacomelli, Carolina Cason, Alfonso Carotenuto, Vincenzo Maria D’Amore, Eleonora Da Pozzo, Barbara Costa, Riccardo Di Leo, Manola Comar, Luciana Marinelli, Claudia Martini, Armando Rossello
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1318 (2022)
Intracellular pathogens, such as Chlamydia trachomatis, have been recently shown to induce degradation of p53 during infection, thus impairing the protective response of the host cells. Therefore, p53 reactivation by disruption of the p53–MDM2 comp
Externí odkaz:
https://doaj.org/article/6617491cc612473bbc9d99a6af5636a2
Autor:
Constantinos G. Neochoritis, Maryam Kazemi Miraki, Eman M. M. Abdelraheem, Ewa Surmiak, Tryfon Zarganes-Tzitzikas, Beata Łabuzek, Tad A. Holak, Alexander Dömling
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 513-520 (2019)
Macrocycles were designed to antagonize the protein–protein interaction p53-MDM2 based on the three-finger pharmacophore F19W23L25. The synthesis was accomplished by a rapid, one-pot synthesis of indole-based macrocycles based on Ugi macrocyclizati
Externí odkaz:
https://doaj.org/article/714269d16b8d497eab7b91bf23d416a7
Autor:
Yali Wang, Bo Ji, Zhongshui Cheng, Lianghui Zhang, Yingying Cheng, Yingying Li, Jin Ren, Wenbo Liu, Yuanyuan Ma
Publikováno v:
Molecules, Vol 27, Iss 12, p 3721 (2022)
A series of novel indolone derivatives were synthesized and evaluated for their binding affinities toward MDM2 and MDMX. Some compounds showed potent MDM2 and moderate MDMX activities. Among them, compound A13 exhibited the most potent affinity towar
Externí odkaz:
https://doaj.org/article/b5c6fbaf1b26426bb2726a89f95d4e4d
Autor:
Daniil R. Bazanov, Nikolay V. Pervushin, Egor V. Savin, Michael D. Tsymliakov, Anita I. Maksutova, Victoria Yu. Savitskaya, Sergey E. Sosonyuk, Yulia A. Gracheva, Michael Yu. Seliverstov, Natalia A. Lozinskaya, Gelina S. Kopeina
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 444 (2022)
The use of p53-MDM2 inhibitors is a prospective strategy in anti-cancer therapy for tumors expressing wild type p53 protein. In this study, we have applied a simple approach of two-step synthesis of imidazoline-based alkoxyaryl compounds, which are a
Externí odkaz:
https://doaj.org/article/86381fec34274d868b2c6af77b718cf2
Akademický článek
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