Zobrazeno 1 - 10
of 171
pro vyhledávání: '"p300-CBP coactivator family"'
Publikováno v:
Biomedicine & Pharmacotherapy. 87:274-279
A majority of acute lymphoblastic leukemia patients overexpress CREB in the bone marrow. However, the functional significance of this up-regulation and the detailed molecular mechanism behind the regulatory effect of CREB on the growth of B-cell prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e197dabeff18368c9385c150d244b33b
https://doi.org/10.1016/j.biopha.2016.12.070
https://doi.org/10.1016/j.biopha.2016.12.070
Publikováno v:
Experimental Hematology. 47:31-35
The transcription factor Myb is a key regulator of hematopoietic cell proliferation, differentiation, and survival and has been implicated in the development of leukemia and several other human cancers. Pharmacological inhibition of Myb is therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4feced95e3f629ba40a74e8ca346bed8
https://doi.org/10.1016/j.exphem.2016.12.003
https://doi.org/10.1016/j.exphem.2016.12.003
Publikováno v:
Oncology Research
The cyclic-AMP response element-binding protein (CREB), a well-known nuclear transcription factor, has been shown to play an essential role in many cellular processes, including differentiation, cell survival, and cell proliferation, by regulating th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7945266cb75d273545c029c1d683b0
https://doi.org/10.3727/096504016x14634208142987
https://doi.org/10.3727/096504016x14634208142987
Publikováno v:
Transplantation Proceedings. 48:2221-2234
Background Cyclic adenosine monophosphate (cAMP) response element–binding protein (CREB) is a member of the CREB/activation transcription factor 1 family that binds to an octanucleotide cAMP response element consensus sequence in promoters of targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e45f3e5cb94591cd43fd0fb8253eee7
https://doi.org/10.1016/j.transproceed.2016.04.023
https://doi.org/10.1016/j.transproceed.2016.04.023
Autor:
K Hsu, Ritika Dutta, S Romanov, A Kaul, Garry P. Nolan, Kathleen M. Sakamoto, Bruce Tiu, Bryan Mitton, Kara L. Davis, Xiangshu Xiao, G Aldana-Masangkay, Elliot M. Landaw, Matteo Pellegrini, F Xie, Hee-Don Chae, Marcus R. Breese, Bingbing X. Li, Roberto Ferrari, Norman J. Lacayo, Gary V. Dahl
Publikováno v:
Leukemia
Leukemia, vol 30, iss 12
Leukemia, vol 30, iss 12
The transcription factor CREB (cAMP Response Element Binding Protein) is overexpressed in the majority of acute myeloid leukemia (AML) patients, and this is associated with a worse prognosis. Previous work revealed that CREB overexpression augmented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd1679e42a84a083c874a0ce2e29567
http://europepmc.org/articles/PMC5143163
http://europepmc.org/articles/PMC5143163
Publikováno v:
Molecular and Cellular Endocrinology. 423:22-29
In this study, we show that reduction of glucose concentration increases TR4 expression in 3T3-L1 cells via stimulation of the GSK-3β-CREB pathway. While GSK-3β and CREB increased TR4 expression in 3T3-L1 cells, inhibition of CREB expression or act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ef50d857814080781b8b0aa5d94998
https://doi.org/10.1016/j.mce.2015.12.023
https://doi.org/10.1016/j.mce.2015.12.023
Autor:
Bernhard Hiebl, Christian V. Recktenwald, André Steven, Chiara Massa, Claudia Wickenhauser, Barbara Seliger, Max Heiduk
Publikováno v:
Molecular Cancer Research. 13:1248-1262
Oncogenic transformation is often associated with an increased expression of the cAMP response element binding (CREB) transcription factor controlling the expression of genes involved in cell proliferation, cell cycle, apoptosis, and tumor developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d39f008d073258d02b5633935bda8e
https://doi.org/10.1158/1541-7786.mcr-14-0590
https://doi.org/10.1158/1541-7786.mcr-14-0590
Publikováno v:
Cancer Letters. 343:98-106
The effect of combining MYB suppression with the histone deacetylase inhibitor LBH589 was studied inhuman myeloid leukemia cell lines. MYB knockdown inhibited proliferation and induced apoptosis inU937 and K562 cells in vitro, and also sensitized bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211ddcd90ad6fccb950140369f7a9f84
https://doi.org/10.1016/j.canlet.2013.09.022
https://doi.org/10.1016/j.canlet.2013.09.022
Publikováno v:
Oncogene. 33:4442-4449
The MYB gene is a master regulator of hematopoiesis and contributes to leukemogenesis in several species including humans. Although it is clear that MYB can promote proliferation, suppress apoptosis and block differentiation, the identities of the MY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aea1d40efdde3eb97cdb21029476b6e
https://doi.org/10.1038/onc.2013.419
https://doi.org/10.1038/onc.2013.419
Autor:
Ernst A. Lien, Ingvild S. Fenne, Michael R. Stallcup, Gunnar Mellgren, Ugo Moens, Mona Johannessen, Tuyen Hoang, Mari Bergsvåg, Andre Madsen, Olivera Bozickovic, Jørn V. Sagen
Publikováno v:
Endocrinology. 154:1513-1527
The glucocorticoid receptor interacting protein (GRIP1) belongs to the p160 steroid receptor coactivator family that plays essential roles in nuclear receptor-dependent transcriptional regulation. Previously, we reported that the cAMP-dependent prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee66a7c1f43a3c203f7cfb588db5272f
https://doi.org/10.1210/en.2012-2049
https://doi.org/10.1210/en.2012-2049