Zobrazeno 1 - 10
of 895
pro vyhledávání: '"p2x7r"'
Autor:
Burak Uzay, Buket Donmez-Demir, Sinem Yilmaz Ozcan, Emine Eren Kocak, Muge Yemisci, Yasemin Gursoy Ozdemir, Turgay Dalkara, Hulya Karatas
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Migraine is a neurological disorder characterized by episodes of severe headache. Cortical spreading depression (CSD), the electrophysiological equivalent of migraine aura, results in opening of pannexin 1 megachannels that release ATP and t
Externí odkaz:
https://doaj.org/article/6372ac1d309c4e7793233ce69eac7fc9
Autor:
Yingtong Lu, Yan Cui, Lu Hou, Yuanfang Jiang, Jingjie Shang, Lu Wang, Hao Xu, Weijian Ye, Yang Qiu, Bin Guo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
ObjectiveTo optimize the automated radiosynthesis of the purinergic ion channel receptor 7 (P2X7R) imaging agent 18F-JNJ64413739 and evaluate its potential for brain imaging in osteoporotic model rats.MethodsA more electron-deficient nitropyridine wa
Externí odkaz:
https://doaj.org/article/d42d1a5ef41a4643b1bc17ca3baef986
Autor:
Jiratchaya Srisutha, Ippei Watari, Masato Akakura, Minami Watanabe, Chidsanu Changsiripun, Takashi Ono
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Type 2 diabetes mellitus (T2DM) is a chronic inflammatory disease that can compromise the functioning of various organs, including the salivary glands (SG). The purinergic system is one of the most important inflammatory pathways in T2DM con
Externí odkaz:
https://doaj.org/article/5514ea2733a84a40b0be9bd7b353e31e
Autor:
Lara Magni, Haoran Yu, Nynne M. Christensen, Mette H. Poulsen, Alexander Frueh, Ganga Deshar, Astrid Z. Johansen, Julia S. Johansen, Stephan A. Pless, Niklas R. Jørgensen, Ivana Novak
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background The purinergic P2X7 receptor (P2X7R) plays an important role in the crosstalk between pancreatic stellate cells (PSCs) and cancer cells, thus promoting progression of pancreatic ductal adenocarcinoma (PDAC). Single nucleotide poly
Externí odkaz:
https://doaj.org/article/fe7eeb715b5d4909a0fb35c22c90c785
Autor:
Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Domenico Caputo, Marco Rovaris, Mario Clerici
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106601- (2024)
Activation of the purinergic receptor P2X7 (P2X7R) is believed to be deleterious in autoimmune diseases and it was hypothesized to play a role in the pathogenesis of MS. P2X7R is an ATP-gated non-selective cationic channel; its activation can be driv
Externí odkaz:
https://doaj.org/article/2ed8c3954f8f487a853c74d47261df0a
Autor:
Liyen K. Kan, Matthew Drill, Padmakrishnan C. Jayakrishnan, Richard P. Sequeira, Paul G. Sanfilippo, Catriona McLean, Martin Hunn, David A. Williams, Terence J. O’Brien, Katharine J. Drummond, Mastura Monif
Publikováno v:
Brain Research Bulletin, Vol 215, Iss , Pp 110996- (2024)
Glioblastoma is the most aggressive and lethal primary brain malignancy with limited treatment options and poor prognosis. Self-renewing glioblastoma cancer stem cells (GSCs) facilitate tumour progression, resistance to conventional treatment and tum
Externí odkaz:
https://doaj.org/article/80c25d4e7f0641f28fbcc87ee26d02d4
Autor:
Xiaoming Liu, Yiwen Li, Liting Huang, Yingyan Kuang, Xiaoxiong Wu, Xiangqiong Ma, Beibei Zhao, Jiao Lan
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The P2X7 receptor (P2X7R), an ATP-gated ion channel, has emerged as a crucial player in neuroinflammation and a promising therapeutic target for neurodegenerative disorders. This review explores the current understanding of P2X7R’s structure, activ
Externí odkaz:
https://doaj.org/article/78a3d623fd144784955a7e0359deb9f8
Autor:
Yuhan Xie, Ranran Han, Yulin Li, Weiya Li, Shichao Zhang, Yu Wu, Yuexin Zhao, Rongrong Liu, Jie Wu, Wei Jiang, Xiuju Chen
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Background Guillain–Barré syndrome (GBS), a post-infectious, immune-mediated, acute demyelinating disease of the peripheral nerves and nerve roots, represents the most prevalent and severe acute paralyzing neuropathy. Purinergic P2X7 rece
Externí odkaz:
https://doaj.org/article/d3dbc5fcb0c344bda70710c84285c49e
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 3, Pp 2544-2552 (2024)
Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disorder, and its pathogenesis remains incompletely understood. This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA seq
Externí odkaz:
https://doaj.org/article/145be4b82022435d8bbc10deefee33fe
Autor:
Naveen Mekala, Jayshil Trivedi, Priyanka Bhoj, Namdev Togre, Slava Rom, Uma Sriram, Yuri Persidsky
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Use of nicotine containing products like electronic cigarettes (e-Cig) and alcohol are associated with mitochondrial membrane depolarization, resulting in the extracellular release of ATP, and mitochondrial DNA (mtDNA), mediating
Externí odkaz:
https://doaj.org/article/4e1cb4136ebb4fef8a3fa6d5d19193d6