Zobrazeno 1 - 10
of 183
pro vyhledávání: '"p15INK4B"'
Autor:
Soon Sang Park, Young-Kyoung Lee, So Hyun Park, Su Bin Lim, Yong Won Choi, Jun Sang Shin, Young Hwa Kim, Jang-Hee Kim, Tae Jun Park
Publikováno v:
Heliyon, Vol 9, Iss 2, Pp e13170- (2023)
Senescent tumor cells are nonproliferating tumor cells which are closely related to cancer progression by secreting senescence-related molecules, called senescence-associated secreting phenotypes. Therefore, the presence of senescent tumor cells is c
Externí odkaz:
https://doaj.org/article/1aeb7c39cf8a4698ba55fde93cbafdef
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/e7f0787c89af4d8f95aa22f02af1c97f
Autor:
Shogo Ijima, Yuki Saito, Kentaro Nagaoka, Sena Yamamoto, Tsukasa Sato, Norihiro Miura, Taiki Iwamoto, Maki Miyajima, Takako S. Chikenji
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by the involvement of multiple organs. Lupus nephritis (LN) is a major risk factor for overall morbidity and mortality in SLE patients. Hence, designing eff
Externí odkaz:
https://doaj.org/article/be71c60f00954e81a4273d59011e2b48
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Background: It is well known that P16INK4A, P14ARF, P15INK4B mRNAs, and ANRIL lncRNA are transcribed from the CDKN2A/2B locus. LncRNA P14AS is a lncRNA transcribed from antisense strand of P14ARF promoter to intron-1. Our previous study showed that P
Externí odkaz:
https://doaj.org/article/5a31450e2db54ef8bb67696d463689ac
Autor:
Umer Farooq, Dimple Notani
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
9p21 locus is one of the most reproducible regions in genome-wide association studies (GWAS). The region harbors CDKN2A/B genes that code for p16INK4a, p15INK4b, and p14ARF proteins, and it also harbors a long gene desert adjacent to these genes. The
Externí odkaz:
https://doaj.org/article/4dbb5a24a5c4423c97722a48394f609a
Akademický článek
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Autor:
Tahereh Dianat, Mohammad Naiem Aminifard, Mohammad Arish, Mohammad Hussein Sangtrash, Robab Poyandeh
Publikováno v:
Journal of Epigenetics, Vol 2, Iss 1, Pp 25-30 (2021)
< p>Background: It is not thoroughly clear that what is the exact etiology of pterygium. Recently, it has been illustrated that pterygium is a benign and destructive condition. The aim of this study was to examine the correlation between promoter hyp
Externí odkaz:
https://doaj.org/article/023efc97150e412991caa524e1d7aae9
Autor:
Debora Bencivenga, Emanuela Stampone, Angela Vastante, Myassar Barahmeh, Fulvio Della Ragione, Adriana Borriello
Publikováno v:
Cells, Vol 11, Iss 8, p 1346 (2022)
It is now definitively established that a large part of the human genome is transcribed. However, only a scarce percentage of the transcriptome (about 1.2%) consists of RNAs that are translated into proteins, while the large majority of transcripts i
Externí odkaz:
https://doaj.org/article/d0585fbdb0e54193bb1e1db283d1f445
Autor:
I I Kostroma, S V Gritsaev, Zh Yu Sidorova, S A Tiranova, S P Svitina, Yu S Drizhun, Zh V Chubukina, I S Martynkevich, S I Kapustin, S S Bessmeltsev
Publikováno v:
Терапевтический архив, Vol 88, Iss 7, Pp 31-36 (2016)
Aim. To investigate the methylation status of the SOX7 and p15NK4b genes and Wnt signaling pathway antagonists in patients with acute myeloid leukemia (AML) in order to assess the association of the rate of aberrant methylation (AM) with the morpholo
Externí odkaz:
https://doaj.org/article/f7ad064eb0044f46b591e2622fc9c032
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 47, Iss 12, Pp 1096-1101 (2014)
p15INK4B, a cyclin-dependent kinase inhibitor, has been recognized as a tumor suppressor. Loss of or methylation of the p15INK4B gene in chronic myeloid leukemia (CML) cells enhances myeloid progenitor formation from common myeloid progenitors. There
Externí odkaz:
https://doaj.org/article/40837ed8026b429ea44c1171468410bb