Zobrazeno 1 - 10
of 234
pro vyhledávání: '"p-tau181"'
Autor:
Roman Sattarov, Megan Havers, Camilla Orbjörn, Erik Stomrud, Shorena Janelidze, Thomas Laurell, Niklas Mattsson-Carlgren
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by brain aggregation of β-amyloid (Aβ) peptides and phosphorylated tau (P-tau) proteins. Extracellular vesicles (EVs) can be isolated and studied for pot
Externí odkaz:
https://doaj.org/article/59e547163a534427b4267f0eb07f69ea
Autor:
Giulia Giacomucci, Salvatore Mazzeo, Assunta Ingannato, Chiara Crucitti, Silvia Bagnoli, Sonia Padiglioni, Lucrezia Romano, Giulia Galdo, Filippo Emiliani, Daniele Frigerio, Camilla Ferrari, Valentina Moschini, Carmen Morinelli, Antonella Notarelli, Sandro Sorbi, Benedetta Nacmias, Valentina Bessi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract We aimed to assess diagnostic accuracy of plasma p-tau181 and NfL separately and in combination in discriminating Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI) patients carrying Alzheimer’s Disease (AD) pathology f
Externí odkaz:
https://doaj.org/article/25b5fa92f220479b9fb15d83e5ed0a59
Autor:
Wei Yang, Fulin Guan, Lihui Yang, Guangli Shou, Fangfang Zhu, Yuanyuan Xu, Ying Meng, Min Li, Wanli Dong
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundPlasma biomarker has the potential to be the reliable and propagable approach in the early stage diagnosis of Alzheimer’s disease (AD). However, conventional methods appear powerless in the detection of these biomarkers at low concentrati
Externí odkaz:
https://doaj.org/article/22221f7e8c804868b78652afe286873e
Autor:
Anna M. Chen, Martin Gajdošík, Wajiha Ahmed, Sinyeob Ahn, James S. Babb, Esther M. Blessing, Allal Boutajangout, Mony J. de Leon, Ludovic Debure, Naomi Gaggi, Mia Gajdošík, Ajax George, Mobeena Ghuman, Lidia Glodzik, Patrick Harvey, Christoph Juchem, Karyn Marsh, Rosemary Peralta, Henry Rusinek, Sulaiman Sheriff, Alok Vedvyas, Thomas Wisniewski, Helena Zheng, Ricardo Osorio, Ivan I. Kirov
Publikováno v:
NeuroImage, Vol 297, Iss , Pp 120742- (2024)
ABSTRACT: Purpose: The pathological hallmarks of Alzheimer's disease (AD), amyloid, tau, and associated neurodegeneration, are present in the cortical gray matter (GM) years before symptom onset, and at significantly greater levels in carriers of the
Externí odkaz:
https://doaj.org/article/df54edeec1d44a40b0c054d4676011a6
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2024)
Alzheimer’s disease (AD) is characterized by a long preclinical phase. Although late-stage AD/dementia may be robustly differentiated from cognitively normal individuals by means of a clinical evaluation, PET imaging, and established biofluid bioma
Externí odkaz:
https://doaj.org/article/3ebe80f4674d462386cdd1e5b77ef3fc
Autor:
Hyuk Sung Kwon, Eun‐Hye Lee, Hyung‐Ji Kim, So‐Hee Park, Hyun‐Hee Park, Jee Hyang Jeong, Seong‐Ho Koh, Seong Hye Choi, Jae‐Hong Lee
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)
Abstract Introduction This study aimed to determine the efficacy of combining plasma phosphorylated tau (p‐tau)181, amyloid beta (Aβ)42/Aβ40, neurofilament light (NfL), and apolipoprotein E (APOE) genotypes for detecting positive amyloid positron
Externí odkaz:
https://doaj.org/article/3c9c3ba984d24b738b07ade03e49a80b
Autor:
Juan Lantero-Rodriguez, Agathe Vrillon, Aida Fernández-Lebrero, Paula Ortiz-Romero, Anniina Snellman, Laia Montoliu-Gaya, Wagner S. Brum, Emmanuel Cognat, Julien Dumurgier, Albert Puig-Pijoan, Irene Navalpotro-Gómez, Greta García-Escobar, Thomas K. Karikari, Eugeen Vanmechelen, Nicholas J. Ashton, Henrik Zetterberg, Marc Suárez-Calvet, Claire Paquet, Kaj Blennow
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Cerebrospinal fluid (CSF) p-tau235 is a novel biomarker highly specific of Alzheimer’s disease (AD). However, CSF p-tau235 has only been studied in well-characterized research cohorts, which do not fully reflect the patient land
Externí odkaz:
https://doaj.org/article/77904aa0f595409998732159a64f7f99
Autor:
Christina Devoto, Rany Vorn, Sara Mithani, Timothy B. Meier, Chen Lai, Steven P. Broglio, Thomas McAllister, Christopher C. Giza, Daniel Huber, Jaroslaw Harezlak, Kenneth L. Cameron, Gerald McGinty, Jonathan Jackson, Kevin Guskiewicz, Jason P. Mihalik, Alison Brooks, Stefan Duma, Steven Rowson, Lindsay D. Nelson, Paul Pasquina, Christine Turtzo, Lawrence Latour, Michael A. McCrea, Jessica M. Gill
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
ObjectiveThe aim of this study was to investigate phosphorylated tau (p-tau181) protein in plasma in a cohort of mild traumatic brain injury (mTBI) patients and a cohort of concussed athletes.MethodsThis pilot study comprised two independent cohorts.
Externí odkaz:
https://doaj.org/article/aed5e343a5bb4736b9c7a4fc8e481853
Autor:
Anniina Snellman, Laura L. Ekblad, Nicholas J. Ashton, Thomas K. Karikari, Juan Lantero-Rodriguez, Elina Pietilä, Mikko Koivumäki, Semi Helin, Mira Karrasch, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne
Publikováno v:
Neurobiology of Disease, Vol 183, Iss , Pp 106175- (2023)
Plasma phosphorylated tau (p-tau) and glial fibrillary acidic protein (GFAP) both reflect early changes in Alzheimer's disease (AD) pathology. Here, we compared the biomarker levels and their association with regional β-amyloid (Aβ) pathology and c
Externí odkaz:
https://doaj.org/article/fe2337a6574743a495a762ce5b91b86e
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